Protein-phosphorylation-responsive polymeric nanoparticles for imaging protein kinase activities in single living cells

Jong Ho Kim, Seulki Lee, Kyeongsoon Park, Yun Nam Hae, Young Jang Soon, Inchan Youn, Kwang Meyung Kim, Hyesung Jeon, Rang Woon Park, In-San Kim, Kuiwon Choi, Ick Chan Kwon

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

(Figure Presented) Take your PIC: Cell-permeable and biocompatible polyion-induced complex (PIC) nanoparticles were developed consisting of a negatively charged polymer along with a positively charged polymer conjugated to a near-infrared fluorophore and a protein-kinase-specific peptide. Owing to profound changes in fluorescence, the PIC nanoparticle is an attractive probe for protein kinase A (PKA) in single living cells. ATP = adenosine triphosphate, ADP = adenosine diphosphate.

Original languageEnglish
Pages (from-to)5779-5782
Number of pages4
JournalAngewandte Chemie - International Edition
Volume46
Issue number30
DOIs
Publication statusPublished - 2007 Aug 3
Externally publishedYes

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Keywords

  • Cell imaging
  • Fluorescent probes
  • Nanoparticles
  • Protein kinases
  • Sensors

ASJC Scopus subject areas

  • Chemistry(all)

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