Proteinticle/Gold Core/Shell Nanoparticles for Targeted Cancer Therapy without Nanotoxicity

Koo Chul Kwon, Ju Hee Ryu, Jong Hwan Lee, Eun Jung Lee, Ick Chan Kwon, Kwangmeyung Kim, Jeewon Lee

Research output: Contribution to journalArticlepeer-review

47 Citations (Scopus)

Abstract

PGCS-NPs (40 nm) with excellent photothermal activity are developed, on the surface of which affibody peptides with specific affinity for EGFR and many small gold dots (1-3 nm) are densely presented. The IV-injected PGCS-NPs into EGFR-expressing tumor-bearing mice successfully perform targeted and photothermal therapy of cancer. It seems that the small gold dots released from disassembled PGCS-NPs are easily removed and never cause in vivo toxicity problems.

Original languageEnglish
Pages (from-to)6436-6441
Number of pages6
JournalAdvanced Materials
Volume26
Issue number37
DOIs
Publication statusPublished - 2014 Oct 1

Keywords

  • core/shell
  • gold nanoparticle
  • nanotoxicity
  • photothermal therapy
  • proteinticle

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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