Proteinuria and hematuria are associated with acute kidney injury and mortality in critically ill patients: A retrospective observational study

Seung Seok Han, Shin Young Ahn, Jiwon Ryu, Seon Ha Baek, Ho Jun Chin, Ki Young Na, Dong Wan Chae, Sejoong Kim

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: Proteinuria and hematuria are both important health issues; however, the nature of the association between these findings and acute kidney injury (AKI) or mortality remains unresolved in critically ill patients. Methods. Proteinuria and hematuria were measured by a dipstick test and scored using a scale ranging from a negative result to 3+ in 1883 patients admitted to the intensive care unit. AKI was defined according to the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines. The odds ratios (ORs) for AKI and 3-year mortality were calculated after adjustment for multiple covariates according to the degree of proteinuria or hematuria. For evaluating the synergistic effect on mortality among proteinuria, hematuria, and AKI, the relative excess risk due to interaction (RERI) was used. Results: Proteinuria and hematuria increased the ORs for AKI: the ORs of proteinuria were 1.66 (+/-), 1.86 (1+), 2.18 (2+), and 4.74 (3+) compared with non-proteinuria; the ORs of hematuria were 1.31 (+/-), 1.58 (1+), 2.63 (2+), and 2.52 (3+) compared with non-hematuria. The correlations between the mortality risk and proteinuria or hematuria were all significant and graded (Ptrend < 0.001). There was a relative excess risk of mortality when both AKI and proteinuria or hematuria were considered together: the synergy indexes were 1.30 and 1.23 for proteinuria and hematuria, respectively. Conclusions: Proteinuria and hematuria are associated with the risks of AKI and mortality in critically ill patients. Additionally, these findings had a synergistic effect with AKI on mortality.

Original languageEnglish
Article number93
JournalBMC Nephrology
Volume15
Issue number1
DOIs
Publication statusPublished - 2014 Jun 18
Externally publishedYes

Fingerprint

Hematuria
Proteinuria
Acute Kidney Injury
Critical Illness
Observational Studies
Retrospective Studies
Mortality
Odds Ratio
Kidney Diseases
Intensive Care Units
Guidelines
Health

Keywords

  • Acute kidney injury
  • Hematuria
  • Intensive care unit
  • Mortality
  • Proteinuria

ASJC Scopus subject areas

  • Nephrology

Cite this

Proteinuria and hematuria are associated with acute kidney injury and mortality in critically ill patients : A retrospective observational study. / Han, Seung Seok; Ahn, Shin Young; Ryu, Jiwon; Baek, Seon Ha; Chin, Ho Jun; Na, Ki Young; Chae, Dong Wan; Kim, Sejoong.

In: BMC Nephrology, Vol. 15, No. 1, 93, 18.06.2014.

Research output: Contribution to journalArticle

Han, Seung Seok ; Ahn, Shin Young ; Ryu, Jiwon ; Baek, Seon Ha ; Chin, Ho Jun ; Na, Ki Young ; Chae, Dong Wan ; Kim, Sejoong. / Proteinuria and hematuria are associated with acute kidney injury and mortality in critically ill patients : A retrospective observational study. In: BMC Nephrology. 2014 ; Vol. 15, No. 1.
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T1 - Proteinuria and hematuria are associated with acute kidney injury and mortality in critically ill patients

T2 - A retrospective observational study

AU - Han, Seung Seok

AU - Ahn, Shin Young

AU - Ryu, Jiwon

AU - Baek, Seon Ha

AU - Chin, Ho Jun

AU - Na, Ki Young

AU - Chae, Dong Wan

AU - Kim, Sejoong

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N2 - Background: Proteinuria and hematuria are both important health issues; however, the nature of the association between these findings and acute kidney injury (AKI) or mortality remains unresolved in critically ill patients. Methods. Proteinuria and hematuria were measured by a dipstick test and scored using a scale ranging from a negative result to 3+ in 1883 patients admitted to the intensive care unit. AKI was defined according to the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines. The odds ratios (ORs) for AKI and 3-year mortality were calculated after adjustment for multiple covariates according to the degree of proteinuria or hematuria. For evaluating the synergistic effect on mortality among proteinuria, hematuria, and AKI, the relative excess risk due to interaction (RERI) was used. Results: Proteinuria and hematuria increased the ORs for AKI: the ORs of proteinuria were 1.66 (+/-), 1.86 (1+), 2.18 (2+), and 4.74 (3+) compared with non-proteinuria; the ORs of hematuria were 1.31 (+/-), 1.58 (1+), 2.63 (2+), and 2.52 (3+) compared with non-hematuria. The correlations between the mortality risk and proteinuria or hematuria were all significant and graded (Ptrend < 0.001). There was a relative excess risk of mortality when both AKI and proteinuria or hematuria were considered together: the synergy indexes were 1.30 and 1.23 for proteinuria and hematuria, respectively. Conclusions: Proteinuria and hematuria are associated with the risks of AKI and mortality in critically ill patients. Additionally, these findings had a synergistic effect with AKI on mortality.

AB - Background: Proteinuria and hematuria are both important health issues; however, the nature of the association between these findings and acute kidney injury (AKI) or mortality remains unresolved in critically ill patients. Methods. Proteinuria and hematuria were measured by a dipstick test and scored using a scale ranging from a negative result to 3+ in 1883 patients admitted to the intensive care unit. AKI was defined according to the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines. The odds ratios (ORs) for AKI and 3-year mortality were calculated after adjustment for multiple covariates according to the degree of proteinuria or hematuria. For evaluating the synergistic effect on mortality among proteinuria, hematuria, and AKI, the relative excess risk due to interaction (RERI) was used. Results: Proteinuria and hematuria increased the ORs for AKI: the ORs of proteinuria were 1.66 (+/-), 1.86 (1+), 2.18 (2+), and 4.74 (3+) compared with non-proteinuria; the ORs of hematuria were 1.31 (+/-), 1.58 (1+), 2.63 (2+), and 2.52 (3+) compared with non-hematuria. The correlations between the mortality risk and proteinuria or hematuria were all significant and graded (Ptrend < 0.001). There was a relative excess risk of mortality when both AKI and proteinuria or hematuria were considered together: the synergy indexes were 1.30 and 1.23 for proteinuria and hematuria, respectively. Conclusions: Proteinuria and hematuria are associated with the risks of AKI and mortality in critically ill patients. Additionally, these findings had a synergistic effect with AKI on mortality.

KW - Acute kidney injury

KW - Hematuria

KW - Intensive care unit

KW - Mortality

KW - Proteinuria

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