Proteogenomic Characterization of Human Early-Onset Gastric Cancer

Dong Gi Mun, Jinhyuk Bhin, Sangok Kim, Hyunwoo Kim, Jae Hun Jung, Yeonjoo Jung, Ye Eun Jang, Jong Moon Park, Hokeun Kim, Yeonhwa Jung, Hangyeore Lee, Jingi Bae, Seunghoon Back, Su Jin Kim, Jieun Kim, Heejin Park, Honglan Li, Kyu Baek Hwang, Young Soo Park, Jeong Hwan YookByung Sik Kim, Sun Young Kwon, Seung Wan Ryu, Do Youn Park, Tae Yong Jeon, Dae Hwan Kim, Jae Hyuck Lee, Sang Uk Han, Kyu Sang Song, Dongmin Park, Jun Won Park, Henry Rodriguez, Jaesang Kim, Hookeun Lee, Kwang Pyo Kim, Eun Gyeong Yang, Hark Kyun Kim, Eunok Paek, Sanghyuk Lee, Sang-Won Lee, Daehee Hwang

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

We report proteogenomic analysis of diffuse gastric cancers (GCs) in young populations. Phosphoproteome data elucidated signaling pathways associated with somatic mutations based on mutation-phosphorylation correlations. Moreover, correlations between mRNA and protein abundances provided potential oncogenes and tumor suppressors associated with patient survival. Furthermore, integrated clustering of mRNA, protein, phosphorylation, and N-glycosylation data identified four subtypes of diffuse GCs. Distinguishing these subtypes was possible by proteomic data. Four subtypes were associated with proliferation, immune response, metabolism, and invasion, respectively; and associations of the subtypes with immune- and invasion-related pathways were identified mainly by phosphorylation and N-glycosylation data. Therefore, our proteogenomic analysis provides additional information beyond genomic analyses, which can improve understanding of cancer biology and patient stratification in diffuse GCs.

Original languageEnglish
Pages (from-to)111-124.e10
JournalCancer Cell
Volume35
Issue number1
DOIs
Publication statusPublished - 2019 Jan 14

Fingerprint

Stomach Neoplasms
Phosphorylation
Glycosylation
Messenger RNA
Mutation
Oncogenes
Proteomics
Cluster Analysis
Neoplasms
Proteins
Survival
Population
Proteogenomics

Keywords

  • cancer subtypes
  • correlation between mRNA and protein abundance changes
  • correlation between mutation and phosphorylation
  • diffuse gastric cancer
  • proteogenomics
  • somatic nonsynonymous mutations

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

Cite this

Mun, D. G., Bhin, J., Kim, S., Kim, H., Jung, J. H., Jung, Y., ... Hwang, D. (2019). Proteogenomic Characterization of Human Early-Onset Gastric Cancer. Cancer Cell, 35(1), 111-124.e10. https://doi.org/10.1016/j.ccell.2018.12.003

Proteogenomic Characterization of Human Early-Onset Gastric Cancer. / Mun, Dong Gi; Bhin, Jinhyuk; Kim, Sangok; Kim, Hyunwoo; Jung, Jae Hun; Jung, Yeonjoo; Jang, Ye Eun; Park, Jong Moon; Kim, Hokeun; Jung, Yeonhwa; Lee, Hangyeore; Bae, Jingi; Back, Seunghoon; Kim, Su Jin; Kim, Jieun; Park, Heejin; Li, Honglan; Hwang, Kyu Baek; Park, Young Soo; Yook, Jeong Hwan; Kim, Byung Sik; Kwon, Sun Young; Ryu, Seung Wan; Park, Do Youn; Jeon, Tae Yong; Kim, Dae Hwan; Lee, Jae Hyuck; Han, Sang Uk; Song, Kyu Sang; Park, Dongmin; Park, Jun Won; Rodriguez, Henry; Kim, Jaesang; Lee, Hookeun; Kim, Kwang Pyo; Yang, Eun Gyeong; Kim, Hark Kyun; Paek, Eunok; Lee, Sanghyuk; Lee, Sang-Won; Hwang, Daehee.

In: Cancer Cell, Vol. 35, No. 1, 14.01.2019, p. 111-124.e10.

Research output: Contribution to journalArticle

Mun, DG, Bhin, J, Kim, S, Kim, H, Jung, JH, Jung, Y, Jang, YE, Park, JM, Kim, H, Jung, Y, Lee, H, Bae, J, Back, S, Kim, SJ, Kim, J, Park, H, Li, H, Hwang, KB, Park, YS, Yook, JH, Kim, BS, Kwon, SY, Ryu, SW, Park, DY, Jeon, TY, Kim, DH, Lee, JH, Han, SU, Song, KS, Park, D, Park, JW, Rodriguez, H, Kim, J, Lee, H, Kim, KP, Yang, EG, Kim, HK, Paek, E, Lee, S, Lee, S-W & Hwang, D 2019, 'Proteogenomic Characterization of Human Early-Onset Gastric Cancer', Cancer Cell, vol. 35, no. 1, pp. 111-124.e10. https://doi.org/10.1016/j.ccell.2018.12.003
Mun DG, Bhin J, Kim S, Kim H, Jung JH, Jung Y et al. Proteogenomic Characterization of Human Early-Onset Gastric Cancer. Cancer Cell. 2019 Jan 14;35(1):111-124.e10. https://doi.org/10.1016/j.ccell.2018.12.003
Mun, Dong Gi ; Bhin, Jinhyuk ; Kim, Sangok ; Kim, Hyunwoo ; Jung, Jae Hun ; Jung, Yeonjoo ; Jang, Ye Eun ; Park, Jong Moon ; Kim, Hokeun ; Jung, Yeonhwa ; Lee, Hangyeore ; Bae, Jingi ; Back, Seunghoon ; Kim, Su Jin ; Kim, Jieun ; Park, Heejin ; Li, Honglan ; Hwang, Kyu Baek ; Park, Young Soo ; Yook, Jeong Hwan ; Kim, Byung Sik ; Kwon, Sun Young ; Ryu, Seung Wan ; Park, Do Youn ; Jeon, Tae Yong ; Kim, Dae Hwan ; Lee, Jae Hyuck ; Han, Sang Uk ; Song, Kyu Sang ; Park, Dongmin ; Park, Jun Won ; Rodriguez, Henry ; Kim, Jaesang ; Lee, Hookeun ; Kim, Kwang Pyo ; Yang, Eun Gyeong ; Kim, Hark Kyun ; Paek, Eunok ; Lee, Sanghyuk ; Lee, Sang-Won ; Hwang, Daehee. / Proteogenomic Characterization of Human Early-Onset Gastric Cancer. In: Cancer Cell. 2019 ; Vol. 35, No. 1. pp. 111-124.e10.
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AU - Jung, Yeonjoo

AU - Jang, Ye Eun

AU - Park, Jong Moon

AU - Kim, Hokeun

AU - Jung, Yeonhwa

AU - Lee, Hangyeore

AU - Bae, Jingi

AU - Back, Seunghoon

AU - Kim, Su Jin

AU - Kim, Jieun

AU - Park, Heejin

AU - Li, Honglan

AU - Hwang, Kyu Baek

AU - Park, Young Soo

AU - Yook, Jeong Hwan

AU - Kim, Byung Sik

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AU - Han, Sang Uk

AU - Song, Kyu Sang

AU - Park, Dongmin

AU - Park, Jun Won

AU - Rodriguez, Henry

AU - Kim, Jaesang

AU - Lee, Hookeun

AU - Kim, Kwang Pyo

AU - Yang, Eun Gyeong

AU - Kim, Hark Kyun

AU - Paek, Eunok

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AU - Lee, Sang-Won

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