Proteogenomic Characterization of Human Early-Onset Gastric Cancer

Dong Gi Mun, Jinhyuk Bhin, Sangok Kim, Hyunwoo Kim, Jae Hun Jung, Yeonjoo Jung, Ye Eun Jang, Jong Moon Park, Hokeun Kim, Yeonhwa Jung, Hangyeore Lee, Jingi Bae, Seunghoon Back, Su Jin Kim, Jieun Kim, Heejin Park, Honglan Li, Kyu Baek Hwang, Young Soo Park, Jeong Hwan YookByung Sik Kim, Sun Young Kwon, Seung Wan Ryu, Do Youn Park, Tae Yong Jeon, Dae Hwan Kim, Jae Hyuck Lee, Sang Uk Han, Kyu Sang Song, Dongmin Park, Jun Won Park, Henry Rodriguez, Jaesang Kim, Hookeun Lee, Kwang Pyo Kim, Eun Gyeong Yang, Hark Kyun Kim, Eunok Paek, Sanghyuk Lee, Sang-Won Lee, Daehee Hwang

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

We report proteogenomic analysis of diffuse gastric cancers (GCs) in young populations. Phosphoproteome data elucidated signaling pathways associated with somatic mutations based on mutation-phosphorylation correlations. Moreover, correlations between mRNA and protein abundances provided potential oncogenes and tumor suppressors associated with patient survival. Furthermore, integrated clustering of mRNA, protein, phosphorylation, and N-glycosylation data identified four subtypes of diffuse GCs. Distinguishing these subtypes was possible by proteomic data. Four subtypes were associated with proliferation, immune response, metabolism, and invasion, respectively; and associations of the subtypes with immune- and invasion-related pathways were identified mainly by phosphorylation and N-glycosylation data. Therefore, our proteogenomic analysis provides additional information beyond genomic analyses, which can improve understanding of cancer biology and patient stratification in diffuse GCs.

Original languageEnglish
Pages (from-to)111-124.e10
JournalCancer Cell
Volume35
Issue number1
DOIs
Publication statusPublished - 2019 Jan 14

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Keywords

  • cancer subtypes
  • correlation between mRNA and protein abundance changes
  • correlation between mutation and phosphorylation
  • diffuse gastric cancer
  • proteogenomics
  • somatic nonsynonymous mutations

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

Cite this

Mun, D. G., Bhin, J., Kim, S., Kim, H., Jung, J. H., Jung, Y., Jang, Y. E., Park, J. M., Kim, H., Jung, Y., Lee, H., Bae, J., Back, S., Kim, S. J., Kim, J., Park, H., Li, H., Hwang, K. B., Park, Y. S., ... Hwang, D. (2019). Proteogenomic Characterization of Human Early-Onset Gastric Cancer. Cancer Cell, 35(1), 111-124.e10. https://doi.org/10.1016/j.ccell.2018.12.003