Abstract
Deficient expression of the mouse proto-oncogene PML is associated with tumor immune evasion, occurring through down-regulated expression of genes involved in antigen processing and presentation. We investigated whether the defective antigen presentation found in human lung cancer cells could be restored by the human homolog of PML. PML induced the expression of MHC class I heavy chain and β 2-microglobulin at the level of transcription, thereby restoring defective antigen presentation resolved in some, but not all, lung cancer cell lines. Furthermore, the capacity of PML to restore antigen presentation required its targeting into nuclear bodies. These findings might have important application in the development of antitumor immunotherapeutic strategies.
| Original language | English |
|---|---|
| Pages (from-to) | 130-135 |
| Number of pages | 6 |
| Journal | Molecules and Cells |
| Volume | 14 |
| Issue number | 1 |
| Publication status | Published - 2002 Aug 1 |
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Keywords
- Antigen Presentation
- Immune Evasion
- MHC
- PML
- Tumor
ASJC Scopus subject areas
- Cell Biology
- Genetics
- Molecular Biology
Cite this
Proto-oncogene PML enhances antigen presentation by MHC class I molecules in human lung cancer cells. / Chang, Sook Kyung; Park, Boyoun; Shin, Jinwook; Ahn, Jin Hyun; Kim, Ik Hwan; Ahn, Kwangseog.
In: Molecules and Cells, Vol. 14, No. 1, 01.08.2002, p. 130-135.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Proto-oncogene PML enhances antigen presentation by MHC class I molecules in human lung cancer cells
AU - Chang, Sook Kyung
AU - Park, Boyoun
AU - Shin, Jinwook
AU - Ahn, Jin Hyun
AU - Kim, Ik Hwan
AU - Ahn, Kwangseog
PY - 2002/8/1
Y1 - 2002/8/1
N2 - Deficient expression of the mouse proto-oncogene PML is associated with tumor immune evasion, occurring through down-regulated expression of genes involved in antigen processing and presentation. We investigated whether the defective antigen presentation found in human lung cancer cells could be restored by the human homolog of PML. PML induced the expression of MHC class I heavy chain and β 2-microglobulin at the level of transcription, thereby restoring defective antigen presentation resolved in some, but not all, lung cancer cell lines. Furthermore, the capacity of PML to restore antigen presentation required its targeting into nuclear bodies. These findings might have important application in the development of antitumor immunotherapeutic strategies.
AB - Deficient expression of the mouse proto-oncogene PML is associated with tumor immune evasion, occurring through down-regulated expression of genes involved in antigen processing and presentation. We investigated whether the defective antigen presentation found in human lung cancer cells could be restored by the human homolog of PML. PML induced the expression of MHC class I heavy chain and β 2-microglobulin at the level of transcription, thereby restoring defective antigen presentation resolved in some, but not all, lung cancer cell lines. Furthermore, the capacity of PML to restore antigen presentation required its targeting into nuclear bodies. These findings might have important application in the development of antitumor immunotherapeutic strategies.
KW - Antigen Presentation
KW - Immune Evasion
KW - MHC
KW - PML
KW - Tumor
UR - http://www.scopus.com/inward/record.url?scp=0037206267&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037206267&partnerID=8YFLogxK
M3 - Article
C2 - 12243342
AN - SCOPUS:0037206267
VL - 14
SP - 130
EP - 135
JO - Molecules and Cells
JF - Molecules and Cells
SN - 1016-8478
IS - 1
ER -