Proton pump inhibitor: The dual role in gastric cancer

Moon Kyung Joo, Jong Jae Park, Hoon Jai Chun

    Research output: Contribution to journalArticlepeer-review

    11 Citations (Scopus)

    Abstract

    Proton pump inhibitors (PPIs) are one of the most frequently used medications for upper gastrointestinal diseases. However, a number of physicians have raised concern about the serious side effects of long-term use of PPIs, including the development of gastric cancer. Recent epidemiological studies have reported a significant association between long-term PPI intake and the risk of gastric cancer, even after successful Helicobacter pylori eradication. However, the effects of PPIs on the development of pre-malignant conditions such as atrophic gastritis or intestinal metaplasia are not fully known, suggesting the need for comprehensive and confirmative studies are needed in the future. Meanwhile, several experimental studies have demonstrated the effects of PPIs in reducing chemoresistance in gastric cancer cells by modulating the acidic microenvironment, cancer stemness and signal transducer and activator of transcription 3 (STAT3) signaling pathway. The inhibitory effects of PPIs on STAT3 activity may overcome drug resistance and enhance the efficacy of conventional or targeted chemotherapeutic agents. Taken together, PPIs may "play dual role" in gastric carcinogenesis and treatment of gastric cancer.

    Original languageEnglish
    Pages (from-to)2058-2070
    Number of pages13
    JournalWorld journal of gastroenterology
    Volume25
    Issue number17
    DOIs
    Publication statusPublished - 2019

    Keywords

    • Astric cancer
    • Drug resistance
    • Proton pump inhibitor
    • Signal transducer and activator of transcription 3

    ASJC Scopus subject areas

    • Gastroenterology

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