Abstract
Proton transfer polymerization between thiol and epoxide groups is shown to be an adaptable and utilitarian method for the synthesis of hydrogels. For instance, the polymerization catalyst can be organic or inorganic, and the polymerization medium can be pure water, buffer solutions, or organic solvents. The gelation mechanism can be triggered at ambient conditions, at a physiological temperature of 37 °C, or through using light as an external stimulus. The ambient and photochemical methods both allow for nanoimprint lithography to produce freestanding patterned thick films. The required thiol- and epoxide-carrying precursors can be chosen from a long list of commercially available small molecular as well as polymeric materials. The water uptake, mechanical, and biodegradation properties of the gels can, therefore, be tuned through the choice of appropriate gelation precursors and polymerization conditions. Finally, the thio-ether groups of the cross-linked networks can be functionalized through a postgelation modification reaction to access sulfonium-based cationic structures. Such structural changes endow antibacterial properties to the networks. In their pristine form, however, the gels are biocompatible and nonadhesive, allowing cancer cells to grow in a cluster formation.
| Original language | English |
|---|---|
| Pages (from-to) | 6700-6709 |
| Number of pages | 10 |
| Journal | Journal of the American Chemical Society |
| Volume | 140 |
| Issue number | 21 |
| DOIs | |
| Publication status | Published - 2018 May 30 |
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ASJC Scopus subject areas
- Catalysis
- Chemistry(all)
- Biochemistry
- Colloid and Surface Chemistry
Cite this
Proton Transfer Hydrogels : Versatility and Applications. / Hwang, Jihyeon; Lee, Dong G.; Yeo, Hyunki; Rao, Jingyi; Zhu, Zhiyuan; Shin, Jawon; Jeong, Keunsoo; Kim, Sehoon; Jung, Hyun Wook; Khan, Anzar.
In: Journal of the American Chemical Society, Vol. 140, No. 21, 30.05.2018, p. 6700-6709.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Proton Transfer Hydrogels
T2 - Versatility and Applications
AU - Hwang, Jihyeon
AU - Lee, Dong G.
AU - Yeo, Hyunki
AU - Rao, Jingyi
AU - Zhu, Zhiyuan
AU - Shin, Jawon
AU - Jeong, Keunsoo
AU - Kim, Sehoon
AU - Jung, Hyun Wook
AU - Khan, Anzar
PY - 2018/5/30
Y1 - 2018/5/30
N2 - Proton transfer polymerization between thiol and epoxide groups is shown to be an adaptable and utilitarian method for the synthesis of hydrogels. For instance, the polymerization catalyst can be organic or inorganic, and the polymerization medium can be pure water, buffer solutions, or organic solvents. The gelation mechanism can be triggered at ambient conditions, at a physiological temperature of 37 °C, or through using light as an external stimulus. The ambient and photochemical methods both allow for nanoimprint lithography to produce freestanding patterned thick films. The required thiol- and epoxide-carrying precursors can be chosen from a long list of commercially available small molecular as well as polymeric materials. The water uptake, mechanical, and biodegradation properties of the gels can, therefore, be tuned through the choice of appropriate gelation precursors and polymerization conditions. Finally, the thio-ether groups of the cross-linked networks can be functionalized through a postgelation modification reaction to access sulfonium-based cationic structures. Such structural changes endow antibacterial properties to the networks. In their pristine form, however, the gels are biocompatible and nonadhesive, allowing cancer cells to grow in a cluster formation.
AB - Proton transfer polymerization between thiol and epoxide groups is shown to be an adaptable and utilitarian method for the synthesis of hydrogels. For instance, the polymerization catalyst can be organic or inorganic, and the polymerization medium can be pure water, buffer solutions, or organic solvents. The gelation mechanism can be triggered at ambient conditions, at a physiological temperature of 37 °C, or through using light as an external stimulus. The ambient and photochemical methods both allow for nanoimprint lithography to produce freestanding patterned thick films. The required thiol- and epoxide-carrying precursors can be chosen from a long list of commercially available small molecular as well as polymeric materials. The water uptake, mechanical, and biodegradation properties of the gels can, therefore, be tuned through the choice of appropriate gelation precursors and polymerization conditions. Finally, the thio-ether groups of the cross-linked networks can be functionalized through a postgelation modification reaction to access sulfonium-based cationic structures. Such structural changes endow antibacterial properties to the networks. In their pristine form, however, the gels are biocompatible and nonadhesive, allowing cancer cells to grow in a cluster formation.
UR - http://www.scopus.com/inward/record.url?scp=85048186378&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85048186378&partnerID=8YFLogxK
U2 - 10.1021/jacs.8b03514
DO - 10.1021/jacs.8b03514
M3 - Article
C2 - 29767509
AN - SCOPUS:85048186378
VL - 140
SP - 6700
EP - 6709
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
SN - 0002-7863
IS - 21
ER -