Proton Transfer Hydrogels: Versatility and Applications

Jihyeon Hwang, Dong G. Lee, Hyunki Yeo, Jingyi Rao, Zhiyuan Zhu, Jawon Shin, Keunsoo Jeong, Sehoon Kim, Hyun Wook Jung, Anzar Khan

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Proton transfer polymerization between thiol and epoxide groups is shown to be an adaptable and utilitarian method for the synthesis of hydrogels. For instance, the polymerization catalyst can be organic or inorganic, and the polymerization medium can be pure water, buffer solutions, or organic solvents. The gelation mechanism can be triggered at ambient conditions, at a physiological temperature of 37 °C, or through using light as an external stimulus. The ambient and photochemical methods both allow for nanoimprint lithography to produce freestanding patterned thick films. The required thiol- and epoxide-carrying precursors can be chosen from a long list of commercially available small molecular as well as polymeric materials. The water uptake, mechanical, and biodegradation properties of the gels can, therefore, be tuned through the choice of appropriate gelation precursors and polymerization conditions. Finally, the thio-ether groups of the cross-linked networks can be functionalized through a postgelation modification reaction to access sulfonium-based cationic structures. Such structural changes endow antibacterial properties to the networks. In their pristine form, however, the gels are biocompatible and nonadhesive, allowing cancer cells to grow in a cluster formation.

Original languageEnglish
Pages (from-to)6700-6709
Number of pages10
JournalJournal of the American Chemical Society
Volume140
Issue number21
DOIs
Publication statusPublished - 2018 May 30

Fingerprint

Hydrogels
Proton transfer
Polymerization
Protons
Epoxy Compounds
Gelation
Sulfhydryl Compounds
Gels
Nanoimprint lithography
Water
Biodegradation
Thick films
Ether
Organic solvents
Ethers
Buffers
Cells
Light
Catalysts
Temperature

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

Proton Transfer Hydrogels : Versatility and Applications. / Hwang, Jihyeon; Lee, Dong G.; Yeo, Hyunki; Rao, Jingyi; Zhu, Zhiyuan; Shin, Jawon; Jeong, Keunsoo; Kim, Sehoon; Jung, Hyun Wook; Khan, Anzar.

In: Journal of the American Chemical Society, Vol. 140, No. 21, 30.05.2018, p. 6700-6709.

Research output: Contribution to journalArticle

Hwang, Jihyeon ; Lee, Dong G. ; Yeo, Hyunki ; Rao, Jingyi ; Zhu, Zhiyuan ; Shin, Jawon ; Jeong, Keunsoo ; Kim, Sehoon ; Jung, Hyun Wook ; Khan, Anzar. / Proton Transfer Hydrogels : Versatility and Applications. In: Journal of the American Chemical Society. 2018 ; Vol. 140, No. 21. pp. 6700-6709.
@article{ca4636734cd640ffa6d7c07496908cbb,
title = "Proton Transfer Hydrogels: Versatility and Applications",
abstract = "Proton transfer polymerization between thiol and epoxide groups is shown to be an adaptable and utilitarian method for the synthesis of hydrogels. For instance, the polymerization catalyst can be organic or inorganic, and the polymerization medium can be pure water, buffer solutions, or organic solvents. The gelation mechanism can be triggered at ambient conditions, at a physiological temperature of 37 °C, or through using light as an external stimulus. The ambient and photochemical methods both allow for nanoimprint lithography to produce freestanding patterned thick films. The required thiol- and epoxide-carrying precursors can be chosen from a long list of commercially available small molecular as well as polymeric materials. The water uptake, mechanical, and biodegradation properties of the gels can, therefore, be tuned through the choice of appropriate gelation precursors and polymerization conditions. Finally, the thio-ether groups of the cross-linked networks can be functionalized through a postgelation modification reaction to access sulfonium-based cationic structures. Such structural changes endow antibacterial properties to the networks. In their pristine form, however, the gels are biocompatible and nonadhesive, allowing cancer cells to grow in a cluster formation.",
author = "Jihyeon Hwang and Lee, {Dong G.} and Hyunki Yeo and Jingyi Rao and Zhiyuan Zhu and Jawon Shin and Keunsoo Jeong and Sehoon Kim and Jung, {Hyun Wook} and Anzar Khan",
year = "2018",
month = "5",
day = "30",
doi = "10.1021/jacs.8b03514",
language = "English",
volume = "140",
pages = "6700--6709",
journal = "Journal of the American Chemical Society",
issn = "0002-7863",
publisher = "American Chemical Society",
number = "21",

}

TY - JOUR

T1 - Proton Transfer Hydrogels

T2 - Versatility and Applications

AU - Hwang, Jihyeon

AU - Lee, Dong G.

AU - Yeo, Hyunki

AU - Rao, Jingyi

AU - Zhu, Zhiyuan

AU - Shin, Jawon

AU - Jeong, Keunsoo

AU - Kim, Sehoon

AU - Jung, Hyun Wook

AU - Khan, Anzar

PY - 2018/5/30

Y1 - 2018/5/30

N2 - Proton transfer polymerization between thiol and epoxide groups is shown to be an adaptable and utilitarian method for the synthesis of hydrogels. For instance, the polymerization catalyst can be organic or inorganic, and the polymerization medium can be pure water, buffer solutions, or organic solvents. The gelation mechanism can be triggered at ambient conditions, at a physiological temperature of 37 °C, or through using light as an external stimulus. The ambient and photochemical methods both allow for nanoimprint lithography to produce freestanding patterned thick films. The required thiol- and epoxide-carrying precursors can be chosen from a long list of commercially available small molecular as well as polymeric materials. The water uptake, mechanical, and biodegradation properties of the gels can, therefore, be tuned through the choice of appropriate gelation precursors and polymerization conditions. Finally, the thio-ether groups of the cross-linked networks can be functionalized through a postgelation modification reaction to access sulfonium-based cationic structures. Such structural changes endow antibacterial properties to the networks. In their pristine form, however, the gels are biocompatible and nonadhesive, allowing cancer cells to grow in a cluster formation.

AB - Proton transfer polymerization between thiol and epoxide groups is shown to be an adaptable and utilitarian method for the synthesis of hydrogels. For instance, the polymerization catalyst can be organic or inorganic, and the polymerization medium can be pure water, buffer solutions, or organic solvents. The gelation mechanism can be triggered at ambient conditions, at a physiological temperature of 37 °C, or through using light as an external stimulus. The ambient and photochemical methods both allow for nanoimprint lithography to produce freestanding patterned thick films. The required thiol- and epoxide-carrying precursors can be chosen from a long list of commercially available small molecular as well as polymeric materials. The water uptake, mechanical, and biodegradation properties of the gels can, therefore, be tuned through the choice of appropriate gelation precursors and polymerization conditions. Finally, the thio-ether groups of the cross-linked networks can be functionalized through a postgelation modification reaction to access sulfonium-based cationic structures. Such structural changes endow antibacterial properties to the networks. In their pristine form, however, the gels are biocompatible and nonadhesive, allowing cancer cells to grow in a cluster formation.

UR - http://www.scopus.com/inward/record.url?scp=85048186378&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85048186378&partnerID=8YFLogxK

U2 - 10.1021/jacs.8b03514

DO - 10.1021/jacs.8b03514

M3 - Article

C2 - 29767509

AN - SCOPUS:85048186378

VL - 140

SP - 6700

EP - 6709

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

SN - 0002-7863

IS - 21

ER -