Protuboxepins A and B and protubonines A and B from the marine-derived fungus Aspergillus sp. SF-5044

Sang Un Lee, Yukihiro Asami, Dongho Lee, Jae Hyuk Jang, Jong Seog Ahn, Hyuncheol Oh

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Two new oxepin-containing (1 and 2) and two diketopiperazine-type alkaloids (3 and 4) have been isolated from an EtOAc extract of the marine-derived fungus Aspergillus sp. SF-5044. The structures of these metabolites were determined through analysis of NMR and MS data, along with Marfey's method. Compound 1 showed weak growth inhibitory activity against a small panel of cell lines. (Chemical Equation Presented).

Original languageEnglish
Pages (from-to)1284-1287
Number of pages4
JournalJournal of Natural Products
Issue number5
Publication statusPublished - 2011 May 27


ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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