Psychopharmacological profile of the water extract of Gardenia jasminoides and its constituents, genipin and geniposide, in mice

Ji Young Choi, Ike Dela Pena, Jong Hyun Choi, Seo Young Yoon, Dong Sool Yim, Yong Soo Lee, Kwang Ho Ko, Chan Young Shin, Jong Hoon Ryu, Won Ki Kim, Jae Hoon Cheong

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5 Citations (Scopus)

Abstract

Gardenia jasminoides (G. jasminoides) is traditionally used to treat insomnia, jaundice, emotional disorders, hepatic disease, and inflammatory disease. Previously, we found that geniposide and the water extract of G. jasminoides increased Cl- influx in neuroblastoma. Here we examined the psychopharmacological activities of G. jasminoides and its constituents. G. jasminoides extract was orally administered at 100 and 200 mg/kg, and genipin and geniposide were intraperitoneally injected at 2, 10, and 20 mg/kg. G. jasminoides extract (200 mg/kg) significantly decreased total open field activity but increased rearing activity in the center of the open field, suggesting an increase in exploratory activity. Genipin and geniposide did not change open field activity, but geniposide (20 mg/kg) increased rearing activity in the central area. The extract (200 mg/kg) significantly decreased rotarod and wire-balancing activity, but genipin and geniposide did not. No compounds influenced thiopental-induced sleeping or electroshock-induced seizures. The extract (200 mg/kg) significantly increased staying time in the open arms of the elevated plus maze and the entry ratio into the open arms, and geniposide (20 mg/kg) also increased open arm entry. Electroshock stress decreased open arm activity, but the extract and geniposide (20 mg/kg) significantly reversed that effect. This results indicate that G. jasminoides extract and geniposide alleviated anxiety with greater efficacy in stressed animals than normal animals.

Original languageEnglish
Pages (from-to)118-125
Number of pages8
JournalBiomolecules and Therapeutics
Volume16
Issue number2
DOIs
Publication statusPublished - 2008 Jun

Keywords

  • Anxiety
  • Behavior
  • Gardenia jasminoides
  • Genipin
  • Geniposide

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery

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    Choi, J. Y., Pena, I. D., Choi, J. H., Yoon, S. Y., Yim, D. S., Lee, Y. S., Ko, K. H., Shin, C. Y., Ryu, J. H., Kim, W. K., & Cheong, J. H. (2008). Psychopharmacological profile of the water extract of Gardenia jasminoides and its constituents, genipin and geniposide, in mice. Biomolecules and Therapeutics, 16(2), 118-125. https://doi.org/10.4062/biomolther.2008.16.2.118