Psychotropic drug-prescribing correlates of disorganized speech in Asians with schizophrenia: The REAP-AP study

Yong Chon Park, Min-Soo Lee, Tian Mei Si, Helen F.K. Chiu, Shigenobu Kanba, Mian Yoon Chong, Adarsh Tripathi, Pichet Udomratn, Kok Yoon Chee, Andi J. Tanra, Golam Rabbani, Afzal Javed, Samudra Kathiarachchi, Win Aung Myint, Tran Van Cuong, Kang Sim, Shu yu Yang, Norman Sartorius, Chay Hoon Tan, Naotaka ShinfukuSeon Cheol Park

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Although disorganized speech is seen as one of the nuclear features of schizophrenia, there have been few reports of disorganized speech-associated psychotropic drug-prescribing patterns in large samples of schizophrenia patients. Objective: We aimed to examine the prevalence of disorganized speech and its correlates in terms of psychotropic drug prescribing, using the data from the Research on Asian Psychotropic Patterns for Antipsychotics (REAP-AP) study. Method: A total of 3744 patients with the ICD-10 diagnosis of schizophrenia were enrolled from 71 survey centers in 15 Asian countries/areas. An essential criterion of disorganized speech was that it was “severe enough to impair substantially effective communication” as defined in the DSM-5. A binary logistic model was fitted to identify the psychotropic drug-prescribing correlates of disorganized speech. Results: After adjusting for the potential effects of confounding variables, the binary logistic regression model showed that the presence of disorganized speech was directly associated with adjunctive use of mood stabilizers (P < 0.001) and cumulative diazepam equivalent dose (P < 0.0001), and inversely associated with adjunctive use of anti-Parkinson drugs (P < 0.0001). Conclusion: The association between disorganized speech and adjunctive use of mood stabilizers could perhaps be understood in the context of a relationship with impulsiveness/aggressiveness, or in terms of deconstructing the Kraepelinian dualism.

Original languageEnglish
JournalSaudi Pharmaceutical Journal
DOIs
Publication statusAccepted/In press - 2018 Jan 1

Fingerprint

Drug Prescriptions
Psychotropic Drugs
Antipsychotic Agents
Schizophrenia
Research
Logistic Models
Confounding Factors (Epidemiology)
International Classification of Diseases
Diazepam
Communication
Pharmaceutical Preparations

Keywords

  • Asian
  • Disorganized speech
  • Mood stabilizers
  • Schizophrenia

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

Cite this

Psychotropic drug-prescribing correlates of disorganized speech in Asians with schizophrenia : The REAP-AP study. / Park, Yong Chon; Lee, Min-Soo; Si, Tian Mei; Chiu, Helen F.K.; Kanba, Shigenobu; Chong, Mian Yoon; Tripathi, Adarsh; Udomratn, Pichet; Chee, Kok Yoon; Tanra, Andi J.; Rabbani, Golam; Javed, Afzal; Kathiarachchi, Samudra; Myint, Win Aung; Cuong, Tran Van; Sim, Kang; Yang, Shu yu; Sartorius, Norman; Tan, Chay Hoon; Shinfuku, Naotaka; Park, Seon Cheol.

In: Saudi Pharmaceutical Journal, 01.01.2018.

Research output: Contribution to journalArticle

Park, YC, Lee, M-S, Si, TM, Chiu, HFK, Kanba, S, Chong, MY, Tripathi, A, Udomratn, P, Chee, KY, Tanra, AJ, Rabbani, G, Javed, A, Kathiarachchi, S, Myint, WA, Cuong, TV, Sim, K, Yang, SY, Sartorius, N, Tan, CH, Shinfuku, N & Park, SC 2018, 'Psychotropic drug-prescribing correlates of disorganized speech in Asians with schizophrenia: The REAP-AP study', Saudi Pharmaceutical Journal. https://doi.org/10.1016/j.jsps.2018.11.006
Park, Yong Chon ; Lee, Min-Soo ; Si, Tian Mei ; Chiu, Helen F.K. ; Kanba, Shigenobu ; Chong, Mian Yoon ; Tripathi, Adarsh ; Udomratn, Pichet ; Chee, Kok Yoon ; Tanra, Andi J. ; Rabbani, Golam ; Javed, Afzal ; Kathiarachchi, Samudra ; Myint, Win Aung ; Cuong, Tran Van ; Sim, Kang ; Yang, Shu yu ; Sartorius, Norman ; Tan, Chay Hoon ; Shinfuku, Naotaka ; Park, Seon Cheol. / Psychotropic drug-prescribing correlates of disorganized speech in Asians with schizophrenia : The REAP-AP study. In: Saudi Pharmaceutical Journal. 2018.
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abstract = "Background: Although disorganized speech is seen as one of the nuclear features of schizophrenia, there have been few reports of disorganized speech-associated psychotropic drug-prescribing patterns in large samples of schizophrenia patients. Objective: We aimed to examine the prevalence of disorganized speech and its correlates in terms of psychotropic drug prescribing, using the data from the Research on Asian Psychotropic Patterns for Antipsychotics (REAP-AP) study. Method: A total of 3744 patients with the ICD-10 diagnosis of schizophrenia were enrolled from 71 survey centers in 15 Asian countries/areas. An essential criterion of disorganized speech was that it was “severe enough to impair substantially effective communication” as defined in the DSM-5. A binary logistic model was fitted to identify the psychotropic drug-prescribing correlates of disorganized speech. Results: After adjusting for the potential effects of confounding variables, the binary logistic regression model showed that the presence of disorganized speech was directly associated with adjunctive use of mood stabilizers (P < 0.001) and cumulative diazepam equivalent dose (P < 0.0001), and inversely associated with adjunctive use of anti-Parkinson drugs (P < 0.0001). Conclusion: The association between disorganized speech and adjunctive use of mood stabilizers could perhaps be understood in the context of a relationship with impulsiveness/aggressiveness, or in terms of deconstructing the Kraepelinian dualism.",
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T2 - The REAP-AP study

AU - Park, Yong Chon

AU - Lee, Min-Soo

AU - Si, Tian Mei

AU - Chiu, Helen F.K.

AU - Kanba, Shigenobu

AU - Chong, Mian Yoon

AU - Tripathi, Adarsh

AU - Udomratn, Pichet

AU - Chee, Kok Yoon

AU - Tanra, Andi J.

AU - Rabbani, Golam

AU - Javed, Afzal

AU - Kathiarachchi, Samudra

AU - Myint, Win Aung

AU - Cuong, Tran Van

AU - Sim, Kang

AU - Yang, Shu yu

AU - Sartorius, Norman

AU - Tan, Chay Hoon

AU - Shinfuku, Naotaka

AU - Park, Seon Cheol

PY - 2018/1/1

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N2 - Background: Although disorganized speech is seen as one of the nuclear features of schizophrenia, there have been few reports of disorganized speech-associated psychotropic drug-prescribing patterns in large samples of schizophrenia patients. Objective: We aimed to examine the prevalence of disorganized speech and its correlates in terms of psychotropic drug prescribing, using the data from the Research on Asian Psychotropic Patterns for Antipsychotics (REAP-AP) study. Method: A total of 3744 patients with the ICD-10 diagnosis of schizophrenia were enrolled from 71 survey centers in 15 Asian countries/areas. An essential criterion of disorganized speech was that it was “severe enough to impair substantially effective communication” as defined in the DSM-5. A binary logistic model was fitted to identify the psychotropic drug-prescribing correlates of disorganized speech. Results: After adjusting for the potential effects of confounding variables, the binary logistic regression model showed that the presence of disorganized speech was directly associated with adjunctive use of mood stabilizers (P < 0.001) and cumulative diazepam equivalent dose (P < 0.0001), and inversely associated with adjunctive use of anti-Parkinson drugs (P < 0.0001). Conclusion: The association between disorganized speech and adjunctive use of mood stabilizers could perhaps be understood in the context of a relationship with impulsiveness/aggressiveness, or in terms of deconstructing the Kraepelinian dualism.

AB - Background: Although disorganized speech is seen as one of the nuclear features of schizophrenia, there have been few reports of disorganized speech-associated psychotropic drug-prescribing patterns in large samples of schizophrenia patients. Objective: We aimed to examine the prevalence of disorganized speech and its correlates in terms of psychotropic drug prescribing, using the data from the Research on Asian Psychotropic Patterns for Antipsychotics (REAP-AP) study. Method: A total of 3744 patients with the ICD-10 diagnosis of schizophrenia were enrolled from 71 survey centers in 15 Asian countries/areas. An essential criterion of disorganized speech was that it was “severe enough to impair substantially effective communication” as defined in the DSM-5. A binary logistic model was fitted to identify the psychotropic drug-prescribing correlates of disorganized speech. Results: After adjusting for the potential effects of confounding variables, the binary logistic regression model showed that the presence of disorganized speech was directly associated with adjunctive use of mood stabilizers (P < 0.001) and cumulative diazepam equivalent dose (P < 0.0001), and inversely associated with adjunctive use of anti-Parkinson drugs (P < 0.0001). Conclusion: The association between disorganized speech and adjunctive use of mood stabilizers could perhaps be understood in the context of a relationship with impulsiveness/aggressiveness, or in terms of deconstructing the Kraepelinian dualism.

KW - Asian

KW - Disorganized speech

KW - Mood stabilizers

KW - Schizophrenia

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