Psyllium husk combined with hydroxycitrate reduces body weight gain and body fat in diet-induced obese rats

Duk Ho Kang, Eun Young Jung, Un Jae Chang, Song Hwan Bae, Hyung Joo Suh

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The fortified physiological activities of psyllium with hydroxycitrate (HCA) will promote the use of this mixture in making nutraceutical foods. Male Sprague-Dawley rats were fed high-fat diets containing fiber-free (control), cellulose (F-control), psyllium husk (WF-1), and psyllium husk + HCA (WF-2) for 4 weeks. Weight gains in WF-2 were significantly lower than those of the control (P < .05). Relative weights of perirenal and epididymal fat in WF-2 were significantly lower than in the other groups (P < .05). The levels of feces bile acid and fat in WF-2 were significantly higher than in the other groups (P < .05). The levels of plasma triacylglycerol and HTR (high-density lipoprotein cholesterol/total cholesterol) in fiber-containing groups (F-control, WF-1 and WF-2) were significantly lower than in the control (P < .05). Especially, triacylglycerol was significantly lower in WF-2 than in WF-1 and F-control (P < .05). Dietary supplementation with psyllium increased the total short-chain fatty acid concentration (23.36 μmol/L in WF-1 and 26.97 μmol/L in WF-2), compared with F-control (18.97 μmol/L) and control (10.92 μmol/L) diets. The mixture of psyllium and HCA reduced both body weight gain and body fat in high fat-fed rats, suggesting efficacy as an antiobesity supplement.

Original languageEnglish
Pages (from-to)349-355
Number of pages7
JournalNutrition Research
Volume27
Issue number6
DOIs
Publication statusPublished - 2007 Jun 1

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Psyllium
Weight Gain
Adipose Tissue
Body Weight
Diet
Fats
Dietary Supplements
Triglycerides
Volatile Fatty Acids
High Fat Diet
Bile Acids and Salts
Feces
Cellulose
HDL Cholesterol
Sprague Dawley Rats
Cholesterol
hydroxycitric acid
Weights and Measures
Food
Control Groups

Keywords

  • Body fat
  • Hydroxycitrate
  • Plasma lipid
  • Psyllium husk
  • Rat
  • Short-chain fatty acid

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Psyllium husk combined with hydroxycitrate reduces body weight gain and body fat in diet-induced obese rats. / Kang, Duk Ho; Jung, Eun Young; Chang, Un Jae; Bae, Song Hwan; Suh, Hyung Joo.

In: Nutrition Research, Vol. 27, No. 6, 01.06.2007, p. 349-355.

Research output: Contribution to journalArticle

Kang, Duk Ho ; Jung, Eun Young ; Chang, Un Jae ; Bae, Song Hwan ; Suh, Hyung Joo. / Psyllium husk combined with hydroxycitrate reduces body weight gain and body fat in diet-induced obese rats. In: Nutrition Research. 2007 ; Vol. 27, No. 6. pp. 349-355.
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