(‒)-Pteroside N and pterosinone, new BACE1 and cholinesterase inhibitors from Pteridium aquilinum

Yun Hyeok Choi, Chun Whan Choi, Jin Kyu Kim, Wonsik Jeong, Gil-Hong Park, Seong Su Hong

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Bioassay-guided fractionation of the ethanolic extract from the whole plants of Pteridium aquilinum has resulted in the isolation of a new pterosin glycoside, (‒)-pteroside N (1), and a new seco-illudoid sesquiterpene, pterosinone (2). Their structures were identified by analysis of the spectroscopic data including extensive 2D NMR. All of the isolates were evaluated for the anti-Alzheimer disease (anti-AD) activity through enzyme inhibition of acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and β-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1). (‒)-Pteroside N (1) showed moderate BACE1 inhibitory activity (IC50 value: 30.6 μM), but exhibited potent inhibitory activity against AChE and BChE (IC50 values: 4.47 and 7.39 μM, respectively). On the other hand, pterosinone (2) showed mild AChE and BChE inhibitory activity (IC50 value: 87.7 and 72.9 μM), but exhibited potent inhibitory activity against BACE1 (IC50 value: 19.4 μM). The results of the present study demonstrate that sesquiterpenoids from P. aquilinum might be beneficial in the treatment of AD.

Original languageEnglish
Pages (from-to)63-68
Number of pages6
JournalPhytochemistry Letters
Volume27
DOIs
Publication statusPublished - 2018 Oct 1

Fingerprint

Pteridium
cholinesterase inhibitors
Butyrylcholinesterase
Pteridium aquilinum
Cholinesterase Inhibitors
Acetylcholinesterase
Inhibitory Concentration 50
inhibitory concentration 50
cholinesterase
acetylcholinesterase
sesquiterpenoids
Enzyme inhibition
Sesquiterpenes
Bioassay
Amyloid beta-Protein Precursor
Fractionation
Glycosides
enzyme inhibition
Plant Extracts
Enzymes

Keywords

  • BACE1
  • Bracken
  • Cholinesterase
  • Pteridium aquilinum
  • Seco-illudoid

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Agronomy and Crop Science
  • Plant Science

Cite this

(‒)-Pteroside N and pterosinone, new BACE1 and cholinesterase inhibitors from Pteridium aquilinum. / Choi, Yun Hyeok; Choi, Chun Whan; Kim, Jin Kyu; Jeong, Wonsik; Park, Gil-Hong; Hong, Seong Su.

In: Phytochemistry Letters, Vol. 27, 01.10.2018, p. 63-68.

Research output: Contribution to journalArticle

Choi, Yun Hyeok ; Choi, Chun Whan ; Kim, Jin Kyu ; Jeong, Wonsik ; Park, Gil-Hong ; Hong, Seong Su. / (‒)-Pteroside N and pterosinone, new BACE1 and cholinesterase inhibitors from Pteridium aquilinum. In: Phytochemistry Letters. 2018 ; Vol. 27. pp. 63-68.
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