PTP1B inhibitory effect of abietane diterpenes isolated from Salvia miltiorrhiza

Yu Mi Han; Hyuncheol Oh; Min Kyun Na; Beom Seok Kim; Won Keun Oh; Bo Yeon Kim; Dae Gwin Jeong; Seong Eon Ryu; Dai Eun Sok; Jong Seog Ahn

doi:10.1248/bpb.28.1795

PTP1B inhibitory effect of abietane diterpenes isolated from Salvia miltiorrhiza

Yu Mi Han, Hyuncheol Oh, Min Kyun Na, Beom Seok Kim, Won Keun Oh, Bo Yeon Kim, Dae Gwin Jeong, Seong Eon Ryu, Dai Eun Sok, Jong Seog Ahn

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

Protein tyrosine phosphatase 1B (PTP1B) acts as a negative regulator of insulin signaling, and selective inhibition of PTP1B has served as a potential drug target for the treatment of type 2 diabetes. In the course of screening for PTP1B inhibitory natural products, the MeOH extract of the dried root of Salvia miltiorrhiza BUNGE (Labiatae) was found to exhibit significant inhibitory effect. Bioassay-guided fractionation and purification afforded three related abietane-type diterpene metabolites 1-3. Compounds 1-3 were identified as isotanshinone IIA (1), dihydroisotanshinone I (2), and isocryptotanshinone (3) mainly by analysis of NMR and MS data. Compounds 1-3 non-competitively inhibited PTP1B activity with 50% inhibitory concentration values of 11.4±0.6 μM, 22.4±0.6 μM and 56.1±6.3 μM, respectively.

Original language	English
Pages (from-to)	1795-1797
Number of pages	3
Journal	Biological and Pharmaceutical Bulletin
Volume	28
Issue number	9
DOIs	https://doi.org/10.1248/bpb.28.1795
Publication status	Published - 2005 Sept
Externally published	Yes

Keywords

Dihydroisotanshinone I
Isocryptotanshinone
Isotanshinone IIA
Labiatae
Protein tyrosine phosphatase 1B (PTP1B) inhibitor
Salvia miltiorrhiza

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1248/bpb.28.1795

Cite this

@article{79d43b64bcd849fdb3e42c9543093871,

title = "PTP1B inhibitory effect of abietane diterpenes isolated from Salvia miltiorrhiza",

abstract = "Protein tyrosine phosphatase 1B (PTP1B) acts as a negative regulator of insulin signaling, and selective inhibition of PTP1B has served as a potential drug target for the treatment of type 2 diabetes. In the course of screening for PTP1B inhibitory natural products, the MeOH extract of the dried root of Salvia miltiorrhiza BUNGE (Labiatae) was found to exhibit significant inhibitory effect. Bioassay-guided fractionation and purification afforded three related abietane-type diterpene metabolites 1-3. Compounds 1-3 were identified as isotanshinone IIA (1), dihydroisotanshinone I (2), and isocryptotanshinone (3) mainly by analysis of NMR and MS data. Compounds 1-3 non-competitively inhibited PTP1B activity with 50% inhibitory concentration values of 11.4±0.6 μM, 22.4±0.6 μM and 56.1±6.3 μM, respectively.",

keywords = "Dihydroisotanshinone I, Isocryptotanshinone, Isotanshinone IIA, Labiatae, Protein tyrosine phosphatase 1B (PTP1B) inhibitor, Salvia miltiorrhiza",

author = "Han, {Yu Mi} and Hyuncheol Oh and Na, {Min Kyun} and Kim, {Beom Seok} and Oh, {Won Keun} and Kim, {Bo Yeon} and Jeong, {Dae Gwin} and Ryu, {Seong Eon} and Sok, {Dai Eun} and Ahn, {Jong Seog}",

year = "2005",

month = sep,

doi = "10.1248/bpb.28.1795",

language = "English",

volume = "28",

pages = "1795--1797",

journal = "Biological and Pharmaceutical Bulletin",

issn = "0918-6158",

publisher = "Pharmaceutical Society of Japan",

number = "9",

}

TY - JOUR

T1 - PTP1B inhibitory effect of abietane diterpenes isolated from Salvia miltiorrhiza

AU - Han, Yu Mi

AU - Oh, Hyuncheol

AU - Na, Min Kyun

AU - Kim, Beom Seok

AU - Oh, Won Keun

AU - Kim, Bo Yeon

AU - Jeong, Dae Gwin

AU - Ryu, Seong Eon

AU - Sok, Dai Eun

AU - Ahn, Jong Seog

PY - 2005/9

Y1 - 2005/9

N2 - Protein tyrosine phosphatase 1B (PTP1B) acts as a negative regulator of insulin signaling, and selective inhibition of PTP1B has served as a potential drug target for the treatment of type 2 diabetes. In the course of screening for PTP1B inhibitory natural products, the MeOH extract of the dried root of Salvia miltiorrhiza BUNGE (Labiatae) was found to exhibit significant inhibitory effect. Bioassay-guided fractionation and purification afforded three related abietane-type diterpene metabolites 1-3. Compounds 1-3 were identified as isotanshinone IIA (1), dihydroisotanshinone I (2), and isocryptotanshinone (3) mainly by analysis of NMR and MS data. Compounds 1-3 non-competitively inhibited PTP1B activity with 50% inhibitory concentration values of 11.4±0.6 μM, 22.4±0.6 μM and 56.1±6.3 μM, respectively.

AB - Protein tyrosine phosphatase 1B (PTP1B) acts as a negative regulator of insulin signaling, and selective inhibition of PTP1B has served as a potential drug target for the treatment of type 2 diabetes. In the course of screening for PTP1B inhibitory natural products, the MeOH extract of the dried root of Salvia miltiorrhiza BUNGE (Labiatae) was found to exhibit significant inhibitory effect. Bioassay-guided fractionation and purification afforded three related abietane-type diterpene metabolites 1-3. Compounds 1-3 were identified as isotanshinone IIA (1), dihydroisotanshinone I (2), and isocryptotanshinone (3) mainly by analysis of NMR and MS data. Compounds 1-3 non-competitively inhibited PTP1B activity with 50% inhibitory concentration values of 11.4±0.6 μM, 22.4±0.6 μM and 56.1±6.3 μM, respectively.

KW - Dihydroisotanshinone I

KW - Isocryptotanshinone

KW - Isotanshinone IIA

KW - Labiatae

KW - Protein tyrosine phosphatase 1B (PTP1B) inhibitor

KW - Salvia miltiorrhiza

UR - http://www.scopus.com/inward/record.url?scp=24944507202&partnerID=8YFLogxK

U2 - 10.1248/bpb.28.1795

DO - 10.1248/bpb.28.1795

M3 - Article

C2 - 16141564

AN - SCOPUS:24944507202

SN - 0918-6158

VL - 28

SP - 1795

EP - 1797

JO - Biological and Pharmaceutical Bulletin

JF - Biological and Pharmaceutical Bulletin

IS - 9

ER -

PTP1B inhibitory effect of abietane diterpenes isolated from Salvia miltiorrhiza

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this