PTP1B inhibitory effect of abietane diterpenes isolated from Salvia miltiorrhiza

Yu Mi Han, Hyuncheol Oh, Min Kyun Na, Beom Seok Kim, Won Keun Oh, Bo Yeon Kim, Dae Gwin Jeong, Seong Eon Ryu, Dai Eun Sok, Jong Seog Ahn

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Protein tyrosine phosphatase 1B (PTP1B) acts as a negative regulator of insulin signaling, and selective inhibition of PTP1B has served as a potential drug target for the treatment of type 2 diabetes. In the course of screening for PTP1B inhibitory natural products, the MeOH extract of the dried root of Salvia miltiorrhiza BUNGE (Labiatae) was found to exhibit significant inhibitory effect. Bioassay-guided fractionation and purification afforded three related abietane-type diterpene metabolites 1-3. Compounds 1-3 were identified as isotanshinone IIA (1), dihydroisotanshinone I (2), and isocryptotanshinone (3) mainly by analysis of NMR and MS data. Compounds 1-3 non-competitively inhibited PTP1B activity with 50% inhibitory concentration values of 11.4±0.6 μM, 22.4±0.6 μM and 56.1±6.3 μM, respectively.

Original languageEnglish
Pages (from-to)1795-1797
Number of pages3
JournalBiological and Pharmaceutical Bulletin
Volume28
Issue number9
DOIs
Publication statusPublished - 2005 Sep
Externally publishedYes

Keywords

  • Dihydroisotanshinone I
  • Isocryptotanshinone
  • Isotanshinone IIA
  • Labiatae
  • Protein tyrosine phosphatase 1B (PTP1B) inhibitor
  • Salvia miltiorrhiza

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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