TY - JOUR
T1 - Puberty-related influences on brain development
AU - Giedd, Jay N.
AU - Clasen, Liv S.
AU - Lenroot, Rhoshel
AU - Greenstein, Dede
AU - Wallace, Gregory L.
AU - Ordaz, Sarah
AU - Molloy, Elizabeth A.
AU - Blumenthal, Jonathan D.
AU - Tossell, Julia W.
AU - Stayer, Catherine
AU - Samango-Sprouse, Carole A.
AU - Shen, Dinggang
AU - Davatzikos, Christos
AU - Merke, Deborah
AU - Chrousos, George P.
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2006/7/25
Y1 - 2006/7/25
N2 - Puberty is a time of striking changes in cognition and behavior. To indirectly assess the effects of puberty-related influences on the underlying neuroanatomy of these behavioral changes we will review and synthesize neuroimaging data from typically developing children and adolescents and from those with anomalous hormone or sex chromosome profiles. The trajectories (size by age) of brain morphometry differ between boys and girls, with girls generally reaching peak gray matter thickness 1-2 years earlier than boys. Both boys and girls with congenital adrenal hyperplasia (characterized by high levels of intrauterine testosterone), have smaller amygdala volume but the brain morphometry of girls with CAH did not otherwise significantly differ from controls. Subjects with XXY have gray matter reductions in the insula, temporal gyri, amygdala, hippocampus, and cingulate-areas consistent with the language-based learning difficulties common in this group.
AB - Puberty is a time of striking changes in cognition and behavior. To indirectly assess the effects of puberty-related influences on the underlying neuroanatomy of these behavioral changes we will review and synthesize neuroimaging data from typically developing children and adolescents and from those with anomalous hormone or sex chromosome profiles. The trajectories (size by age) of brain morphometry differ between boys and girls, with girls generally reaching peak gray matter thickness 1-2 years earlier than boys. Both boys and girls with congenital adrenal hyperplasia (characterized by high levels of intrauterine testosterone), have smaller amygdala volume but the brain morphometry of girls with CAH did not otherwise significantly differ from controls. Subjects with XXY have gray matter reductions in the insula, temporal gyri, amygdala, hippocampus, and cingulate-areas consistent with the language-based learning difficulties common in this group.
KW - Brain
KW - Children and adolescents
KW - Congenital adrenal hyperplasia
KW - Magnetic resonance imaging
KW - Puberty
KW - Sex chromosome aneuploidy
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U2 - 10.1016/j.mce.2006.04.016
DO - 10.1016/j.mce.2006.04.016
M3 - Article
C2 - 16765510
AN - SCOPUS:33745927160
VL - 254-255
SP - 154
EP - 162
JO - Molecular and Cellular Endocrinology
JF - Molecular and Cellular Endocrinology
SN - 0303-7207
ER -