Puberty-related influences on brain development

Jay N. Giedd; Liv S. Clasen; Rhoshel Lenroot; Dede Greenstein; Gregory L. Wallace; Sarah Ordaz; Elizabeth A. Molloy; Jonathan D. Blumenthal; Julia W. Tossell; Catherine Stayer; Carole A. Samango-Sprouse; Dinggang Shen; Christos Davatzikos; Deborah Merke; George P. Chrousos

doi:10.1016/j.mce.2006.04.016

Puberty-related influences on brain development

Jay N. Giedd, Liv S. Clasen, Rhoshel Lenroot, Dede Greenstein, Gregory L. Wallace, Sarah Ordaz, Elizabeth A. Molloy, Jonathan D. Blumenthal, Julia W. Tossell, Catherine Stayer, Carole A. Samango-Sprouse, Dinggang Shen, Christos Davatzikos, Deborah Merke, George P. Chrousos

Research output: Contribution to journal › Article › peer-review

212 Citations (Scopus)

Abstract

Puberty is a time of striking changes in cognition and behavior. To indirectly assess the effects of puberty-related influences on the underlying neuroanatomy of these behavioral changes we will review and synthesize neuroimaging data from typically developing children and adolescents and from those with anomalous hormone or sex chromosome profiles. The trajectories (size by age) of brain morphometry differ between boys and girls, with girls generally reaching peak gray matter thickness 1-2 years earlier than boys. Both boys and girls with congenital adrenal hyperplasia (characterized by high levels of intrauterine testosterone), have smaller amygdala volume but the brain morphometry of girls with CAH did not otherwise significantly differ from controls. Subjects with XXY have gray matter reductions in the insula, temporal gyri, amygdala, hippocampus, and cingulate-areas consistent with the language-based learning difficulties common in this group.

Original language	English
Pages (from-to)	154-162
Number of pages	9
Journal	Molecular and Cellular Endocrinology
Volume	254-255
DOIs	https://doi.org/10.1016/j.mce.2006.04.016
Publication status	Published - 2006 Jul 25
Externally published	Yes

Keywords

Brain
Children and adolescents
Congenital adrenal hyperplasia
Magnetic resonance imaging
Puberty
Sex chromosome aneuploidy

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Endocrinology

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10.1016/j.mce.2006.04.016

Cite this

Giedd, J. N., Clasen, L. S., Lenroot, R., Greenstein, D., Wallace, G. L., Ordaz, S., Molloy, E. A., Blumenthal, J. D., Tossell, J. W., Stayer, C., Samango-Sprouse, C. A., Shen, D., Davatzikos, C., Merke, D., & Chrousos, G. P. (2006). Puberty-related influences on brain development. Molecular and Cellular Endocrinology, 254-255, 154-162. https://doi.org/10.1016/j.mce.2006.04.016

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abstract = "Puberty is a time of striking changes in cognition and behavior. To indirectly assess the effects of puberty-related influences on the underlying neuroanatomy of these behavioral changes we will review and synthesize neuroimaging data from typically developing children and adolescents and from those with anomalous hormone or sex chromosome profiles. The trajectories (size by age) of brain morphometry differ between boys and girls, with girls generally reaching peak gray matter thickness 1-2 years earlier than boys. Both boys and girls with congenital adrenal hyperplasia (characterized by high levels of intrauterine testosterone), have smaller amygdala volume but the brain morphometry of girls with CAH did not otherwise significantly differ from controls. Subjects with XXY have gray matter reductions in the insula, temporal gyri, amygdala, hippocampus, and cingulate-areas consistent with the language-based learning difficulties common in this group.",

keywords = "Brain, Children and adolescents, Congenital adrenal hyperplasia, Magnetic resonance imaging, Puberty, Sex chromosome aneuploidy",

author = "Giedd, {Jay N.} and Clasen, {Liv S.} and Rhoshel Lenroot and Dede Greenstein and Wallace, {Gregory L.} and Sarah Ordaz and Molloy, {Elizabeth A.} and Blumenthal, {Jonathan D.} and Tossell, {Julia W.} and Catherine Stayer and Samango-Sprouse, {Carole A.} and Dinggang Shen and Christos Davatzikos and Deborah Merke and Chrousos, {George P.}",

year = "2006",

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doi = "10.1016/j.mce.2006.04.016",

language = "English",

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AU - Molloy, Elizabeth A.

AU - Blumenthal, Jonathan D.

AU - Tossell, Julia W.

AU - Stayer, Catherine

AU - Samango-Sprouse, Carole A.

AU - Shen, Dinggang

AU - Davatzikos, Christos

AU - Merke, Deborah

AU - Chrousos, George P.

PY - 2006/7/25

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KW - Sex chromosome aneuploidy

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Puberty-related influences on brain development

Abstract

Keywords

ASJC Scopus subject areas

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