Pulmonary artery pressure in chronic obstructive pulmonary disease without resting hypoxaemia

J. H. Lee, Yeon Mok Oh, J. B. Seo, Y. K. Lee, W. J. Kim, S. S. Sheen, T. H. Kim, J. H. Lee, E. K. Kim, J. S. Lee, J. W. Huh, S. Y. Lim, H. I. Yoon, T. R. Shin, S. M. Lee, Sang Yeub Lee, Sang Do Lee

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6 Citations (Scopus)

Abstract

BACKGROUND: Chronic obstructive pulmonary disease (COPD) can lead to pulmonary hypertension and cor pulmonale, which are predictors of mortality. OBJECTIVE: To identify predictors of increased pulmonary artery pressure (PAP) in COPD patients without resting hypoxaemia, and to characterise COPD patients with increased PAP. DESIGN: A study of 117 COPD patients from the Korean Obstructive Lung Disease (KOLD) cohort who had measurable tricuspid regurgitant flow under transthoracic Doppler echocardiography and no resting hypoxaemia. RESULTS: The mean patient age was 67 years. Mean forced expiratory volume in 1 second (FEV1) was 47% predicted, mean haemoglobin (Hb) concentration was 145 g/l and mean systolic PAP (sPAP) was 33 mmHg. Multiple linear regression analysis showed that Hb was the only factor independently associated with sPAP (beta = -1.752, P = 0.005). Cluster analysis using FEV 1% predicted, sPAP and Hb concentration as variables indicated three patient clusters: Cluster 1 (n = 36; mean FEV 1 44% predicted, mean sPAP 39 mmHg, mean Hb 132 g/l), Cluster 2 (n = 45; FEV 1 35% predicted, sPAP 31 mmHg, Hb 154 g/l), and Cluster 3 (n = 36; FEV 1 65% predicted, sPAP 29 mmHg, Hb 148 g/l). CONCLUSION: Elevated PAP was linked to low haemoglobin levels in COPD without resting hypoxaemia.

Original languageEnglish
JournalInternational Journal of Tuberculosis and Lung Disease
Volume15
Issue number6
DOIs
Publication statusPublished - 2011 Jun 1

Keywords

  • COPD
  • Echocardiography
  • Haemoglobin
  • Pulmonary artery pressure

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

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    Lee, J. H., Oh, Y. M., Seo, J. B., Lee, Y. K., Kim, W. J., Sheen, S. S., Kim, T. H., Lee, J. H., Kim, E. K., Lee, J. S., Huh, J. W., Lim, S. Y., Yoon, H. I., Shin, T. R., Lee, S. M., Lee, S. Y., & Lee, S. D. (2011). Pulmonary artery pressure in chronic obstructive pulmonary disease without resting hypoxaemia. International Journal of Tuberculosis and Lung Disease, 15(6). https://doi.org/10.5588/ijtld.10.0598