Pulmonary fibrosis under chemotherapy with oxaliplatin, 5-fluorouracil, and leucovorin

Jin Yong Jung, Gyu Young Hur, Ki Hwan Jung, Hae Chul Jung, Sung Yong Lee, In Keun Choi, Sang Yeub Lee, Je Hyeong Kim, Jae Hong Seo, Chol Shin, Jae Jeong Shim, Kwang Ho In, Kyung Ho Kang, Se Hwa Yoo

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Abstract

The combination of oxaliplatin, 5-fluorouracil and leucovorin (FOLFOX) has recently been shown to be beneficial in advanced colorectal and gastric cancers. The side effects of this regimen include neutropenia, diarrhea and neurosensory toxicity. However, case reports on the pulmonary toxicities of this regimen are very limited. Especially, the development of pulmonary fibrosis has never been cited in the literature. Herein is reported the case of a patient treated with oxaliplatin, 5 fluorouracil and leucovorin combination chemotherapy in whom pulmonary fibrosis developed, but which improved after steroid pulse therapy.

Original languageEnglish
Pages (from-to)536-540
Number of pages5
JournalTuberculosis and Respiratory Diseases
Volume59
Issue number5
Publication statusPublished - 2005 Nov 1

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Keywords

  • Chemotherapy
  • Fluorouracil
  • Leucovorin
  • Oxaliplatin
  • Pulmonary fibrosis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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