Putative association between UBE2E2 polymorphisms and the risk of gestational diabetes mellitus

Jason Y. Kim, Hyun Sub Cheong, Byung Lae Park, Sei Hyun Baik, Sunmin Park, Seogho Kim, Hyoung Doo Shin, Sung Hoon Kim

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We hypothesized that ubiquitin-conjugating enzyme E2 E2 (UBE2E2) may be associated with gestational diabetes mellitus (GDM) and conducted association analyses. A total of 2071 subjects were recruited for the study, with 1104 cases and 967 controls. Two UBE2E2 single-nucleotide polymorphisms rs6780569 and rs7612463, and their haplotypes were analyzed for the study. As a result, rs7612463 showed a significant association with GDM in the recessive model. In addition, the regression analyses for the phenotypes showed that rs6780569. rs7612463 and ht2 showed significant associations with fasting plasma glucose (FPG) in recessive models, while ht1 showed an association in the dominant model. Our results show that the genetic variants of UBE2E2 are associated with GDM and FPG, which could be an important preliminary result for future studies.

Original languageEnglish
Pages (from-to)904-908
Number of pages5
JournalGynecological Endocrinology
Volume29
Issue number10
DOIs
Publication statusPublished - 2013 Oct

Keywords

  • Gestational diabetes mellitus
  • Haplotype
  • Single-nucleotide polymorphism
  • Ubiquitin-conjugating enzyme E2 E2

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Obstetrics and Gynaecology

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    Kim, J. Y., Cheong, H. S., Park, B. L., Baik, S. H., Park, S., Kim, S., Shin, H. D., & Kim, S. H. (2013). Putative association between UBE2E2 polymorphisms and the risk of gestational diabetes mellitus. Gynecological Endocrinology, 29(10), 904-908. https://doi.org/10.3109/09513590.2013.813465