Pyranocoumarins from Glehnia littoralis inhibit the LPS-induced NO production in macrophage RAW 264.7 cells

Jin Woo Lee, Chul Lee, Qinghao Jin, Eung Tae Yeon, Dongho Lee, Soo Young Kim, Sang Bae Han, Jin Tae Hong, Mi Kyeong Lee, Bang Yeon Hwang

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A new dihydropyranocoumarin, (+)-cis-(3′S,4′S)- diisobutyrylkhellactone (1), together with five known compounds, 3′-senecioyl-4′-acetylkhellactone (2), 3′-isovaleryl-4′- acetylkhellactone (3), 3′,4′-disenecioylkhellactone (4), 3′-isovaleryl-4′-senecioylkhellactone (5), and 3′,4′- diisovalerylkhellactone (6), was isolated from Glehnia littoralis. Their chemical structures were elucidated based on the spectroscopic data interpretation, particularly 1D and 2D NMR data including HMQC and HMBC. All the isolated compounds showed the potential to inhibit LPS-induced nitric oxide production in RAW 264.7 cells with IC50 values ranging from 7.4 to 44.3 μM.

Original languageEnglish
Pages (from-to)2717-2719
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume24
Issue number12
DOIs
Publication statusPublished - 2014 Jun 15

Keywords

  • Apiaceae
  • Dihydropyranocoumarin
  • Glehnia littoralis
  • Nitric oxide production inhibitor

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Molecular Biology
  • Molecular Medicine
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

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  • Cite this

    Lee, J. W., Lee, C., Jin, Q., Yeon, E. T., Lee, D., Kim, S. Y., Han, S. B., Hong, J. T., Lee, M. K., & Hwang, B. Y. (2014). Pyranocoumarins from Glehnia littoralis inhibit the LPS-induced NO production in macrophage RAW 264.7 cells. Bioorganic and Medicinal Chemistry Letters, 24(12), 2717-2719. https://doi.org/10.1016/j.bmcl.2014.04.046