Pyranoflavanones and Pyranochalcones from the Fruits of Amomum tsao-ko

Jun Gu Kim; Hari Jang; Thi Phuong Linh Le; Hye Ryoung Hong; Mi Kyeong Lee; Jin Tae Hong; Dongho Lee; Bang Yeon Hwang

doi:10.1021/acs.jnatprod.9b00155

Pyranoflavanones and Pyranochalcones from the Fruits of Amomum tsao-ko

Jun Gu Kim, Hari Jang, Thi Phuong Linh Le, Hye Ryoung Hong, Mi Kyeong Lee, Jin Tae Hong, Dongho Lee, Bang Yeon Hwang

Department of Biosystems and Biotechnology

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Eight new geranylated and farnesylated pyranoflavanones (1-8) and two new farnesylated pyranochalcones (9 and 10) were isolated from the methanolic extract of the fruits of Amomum tsao-ko. Their structures were elucidated by extensive analysis of the 1D and 2D NMR spectra and from the HRESIMS, combined with experimental ECD data. All compounds were evaluated for their inhibitory effects on the nitric oxide production against lipopolysaccharide-induced RAW 264.7 macrophages and exhibited IC₅₀ values ranging from 10.6 to 41.5 μM.

Original language	English
Pages (from-to)	1886-1892
Number of pages	7
Journal	Journal of Natural Products
Volume	82
Issue number	7
DOIs	https://doi.org/10.1021/acs.jnatprod.9b00155
Publication status	Published - 2019 Jul 26

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/acs.jnatprod.9b00155

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title = "Pyranoflavanones and Pyranochalcones from the Fruits of Amomum tsao-ko",

abstract = "Eight new geranylated and farnesylated pyranoflavanones (1-8) and two new farnesylated pyranochalcones (9 and 10) were isolated from the methanolic extract of the fruits of Amomum tsao-ko. Their structures were elucidated by extensive analysis of the 1D and 2D NMR spectra and from the HRESIMS, combined with experimental ECD data. All compounds were evaluated for their inhibitory effects on the nitric oxide production against lipopolysaccharide-induced RAW 264.7 macrophages and exhibited IC50 values ranging from 10.6 to 41.5 μM.",

author = "Kim, {Jun Gu} and Hari Jang and Le, {Thi Phuong Linh} and Hong, {Hye Ryoung} and Lee, {Mi Kyeong} and Hong, {Jin Tae} and Dongho Lee and Hwang, {Bang Yeon}",

note = "Funding Information: This research was supported by the Medical Research Center Program (MRC, 2017R1A5A2015541) through the National Research Foundation of Korea and by the Korea Basic Science Institute under the R&D program (Project No. D39700) supervised by the Ministry of Science and ICT. Publisher Copyright: {\textcopyright} 2019 American Chemical Society and American Society of Pharmacognosy.",

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doi = "10.1021/acs.jnatprod.9b00155",

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AU - Kim, Jun Gu

AU - Jang, Hari

AU - Le, Thi Phuong Linh

AU - Hong, Hye Ryoung

AU - Lee, Mi Kyeong

AU - Hong, Jin Tae

AU - Lee, Dongho

AU - Hwang, Bang Yeon

N1 - Funding Information: This research was supported by the Medical Research Center Program (MRC, 2017R1A5A2015541) through the National Research Foundation of Korea and by the Korea Basic Science Institute under the R&D program (Project No. D39700) supervised by the Ministry of Science and ICT. Publisher Copyright: © 2019 American Chemical Society and American Society of Pharmacognosy.

PY - 2019/7/26

Y1 - 2019/7/26

N2 - Eight new geranylated and farnesylated pyranoflavanones (1-8) and two new farnesylated pyranochalcones (9 and 10) were isolated from the methanolic extract of the fruits of Amomum tsao-ko. Their structures were elucidated by extensive analysis of the 1D and 2D NMR spectra and from the HRESIMS, combined with experimental ECD data. All compounds were evaluated for their inhibitory effects on the nitric oxide production against lipopolysaccharide-induced RAW 264.7 macrophages and exhibited IC50 values ranging from 10.6 to 41.5 μM.

AB - Eight new geranylated and farnesylated pyranoflavanones (1-8) and two new farnesylated pyranochalcones (9 and 10) were isolated from the methanolic extract of the fruits of Amomum tsao-ko. Their structures were elucidated by extensive analysis of the 1D and 2D NMR spectra and from the HRESIMS, combined with experimental ECD data. All compounds were evaluated for their inhibitory effects on the nitric oxide production against lipopolysaccharide-induced RAW 264.7 macrophages and exhibited IC50 values ranging from 10.6 to 41.5 μM.

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Pyranoflavanones and Pyranochalcones from the Fruits of Amomum tsao-ko

Abstract

ASJC Scopus subject areas

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