Pyranoflavanones and Pyranochalcones from the Fruits of Amomum tsao-ko

Jun Gu Kim, Hari Jang, Thi Phuong Linh Le, Hye Ryoung Hong, Mi Kyeong Lee, Jin Tae Hong, Dongho Lee, Bang Yeon Hwang

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Abstract

Eight new geranylated and farnesylated pyranoflavanones (1-8) and two new farnesylated pyranochalcones (9 and 10) were isolated from the methanolic extract of the fruits of Amomum tsao-ko. Their structures were elucidated by extensive analysis of the 1D and 2D NMR spectra and from the HRESIMS, combined with experimental ECD data. All compounds were evaluated for their inhibitory effects on the nitric oxide production against lipopolysaccharide-induced RAW 264.7 macrophages and exhibited IC50 values ranging from 10.6 to 41.5 μM.

Original languageEnglish
Pages (from-to)1886-1892
Number of pages7
JournalJournal of Natural Products
Volume82
Issue number7
DOIs
Publication statusPublished - 2019 Jan 1

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ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Cite this

Kim, J. G., Jang, H., Le, T. P. L., Hong, H. R., Lee, M. K., Hong, J. T., Lee, D., & Hwang, B. Y. (2019). Pyranoflavanones and Pyranochalcones from the Fruits of Amomum tsao-ko. Journal of Natural Products, 82(7), 1886-1892. https://doi.org/10.1021/acs.jnatprod.9b00155