Pyrophosphate-selective fluorescent chemosensor based on 1,8-Naphthalimide-DPA-Zn(II) Complex and its application for cell imaging

Jun Feng Zhang, Sooyeon Kim, Ji Hae Han, Seung Jea Lee, Tuhin Pradhan, Qian Yong Cao, Suk Joong Lee, Chulhun Kang, Jong Seung Kim

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Abstract

A new zinc(II) complex with a two-dipicolylamine-substituted 1,8-naphthalimide for recognition of pyrophosphate with ratiometrical fluorescence changes in aqueous solution has been synthesized and characterized. Its biological application to monitor the intracellular pyrophosphate (PPi) was successfully demonstrated by the observation that the fluorescence of 1 was enhanced by the presence of the Zn 2+ion and was quenched by addition of PPi.

Original languageEnglish
Pages (from-to)5294-5297
Number of pages4
JournalOrganic Letters
Volume13
Issue number19
DOIs
Publication statusPublished - 2011 Oct 7

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ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

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