Pyrophosphate-selective fluorescent chemosensor based on 1,8-Naphthalimide-DPA-Zn(II) Complex and its application for cell imaging

Jun Feng Zhang, Sooyeon Kim, Ji Hae Han, Seung Jea Lee, Tuhin Pradhan, Qian Yong Cao, Suk Joong Lee, Chulhun Kang, Jong Seung Kim

Research output: Contribution to journalArticle

136 Citations (Scopus)

Abstract

A new zinc(II) complex with a two-dipicolylamine-substituted 1,8-naphthalimide for recognition of pyrophosphate with ratiometrical fluorescence changes in aqueous solution has been synthesized and characterized. Its biological application to monitor the intracellular pyrophosphate (PPi) was successfully demonstrated by the observation that the fluorescence of 1 was enhanced by the presence of the Zn 2+ion and was quenched by addition of PPi.

Original languageEnglish
Pages (from-to)5294-5297
Number of pages4
JournalOrganic Letters
Volume13
Issue number19
DOIs
Publication statusPublished - 2011 Oct 7

Fingerprint

Naphthalimides
Fluorescence
Imaging techniques
fluorescence
cells
Zinc
zinc
Ions
aqueous solutions
ions
diphosphoric acid

ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

Cite this

Pyrophosphate-selective fluorescent chemosensor based on 1,8-Naphthalimide-DPA-Zn(II) Complex and its application for cell imaging. / Zhang, Jun Feng; Kim, Sooyeon; Han, Ji Hae; Lee, Seung Jea; Pradhan, Tuhin; Cao, Qian Yong; Lee, Suk Joong; Kang, Chulhun; Kim, Jong Seung.

In: Organic Letters, Vol. 13, No. 19, 07.10.2011, p. 5294-5297.

Research output: Contribution to journalArticle

Zhang, Jun Feng ; Kim, Sooyeon ; Han, Ji Hae ; Lee, Seung Jea ; Pradhan, Tuhin ; Cao, Qian Yong ; Lee, Suk Joong ; Kang, Chulhun ; Kim, Jong Seung. / Pyrophosphate-selective fluorescent chemosensor based on 1,8-Naphthalimide-DPA-Zn(II) Complex and its application for cell imaging. In: Organic Letters. 2011 ; Vol. 13, No. 19. pp. 5294-5297.
@article{4afc17e7e99a4bb480df594963910e0c,
title = "Pyrophosphate-selective fluorescent chemosensor based on 1,8-Naphthalimide-DPA-Zn(II) Complex and its application for cell imaging",
abstract = "A new zinc(II) complex with a two-dipicolylamine-substituted 1,8-naphthalimide for recognition of pyrophosphate with ratiometrical fluorescence changes in aqueous solution has been synthesized and characterized. Its biological application to monitor the intracellular pyrophosphate (PPi) was successfully demonstrated by the observation that the fluorescence of 1 was enhanced by the presence of the Zn 2+ion and was quenched by addition of PPi.",
author = "Zhang, {Jun Feng} and Sooyeon Kim and Han, {Ji Hae} and Lee, {Seung Jea} and Tuhin Pradhan and Cao, {Qian Yong} and Lee, {Suk Joong} and Chulhun Kang and Kim, {Jong Seung}",
year = "2011",
month = "10",
day = "7",
doi = "10.1021/ol202159x",
language = "English",
volume = "13",
pages = "5294--5297",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "19",

}

TY - JOUR

T1 - Pyrophosphate-selective fluorescent chemosensor based on 1,8-Naphthalimide-DPA-Zn(II) Complex and its application for cell imaging

AU - Zhang, Jun Feng

AU - Kim, Sooyeon

AU - Han, Ji Hae

AU - Lee, Seung Jea

AU - Pradhan, Tuhin

AU - Cao, Qian Yong

AU - Lee, Suk Joong

AU - Kang, Chulhun

AU - Kim, Jong Seung

PY - 2011/10/7

Y1 - 2011/10/7

N2 - A new zinc(II) complex with a two-dipicolylamine-substituted 1,8-naphthalimide for recognition of pyrophosphate with ratiometrical fluorescence changes in aqueous solution has been synthesized and characterized. Its biological application to monitor the intracellular pyrophosphate (PPi) was successfully demonstrated by the observation that the fluorescence of 1 was enhanced by the presence of the Zn 2+ion and was quenched by addition of PPi.

AB - A new zinc(II) complex with a two-dipicolylamine-substituted 1,8-naphthalimide for recognition of pyrophosphate with ratiometrical fluorescence changes in aqueous solution has been synthesized and characterized. Its biological application to monitor the intracellular pyrophosphate (PPi) was successfully demonstrated by the observation that the fluorescence of 1 was enhanced by the presence of the Zn 2+ion and was quenched by addition of PPi.

UR - http://www.scopus.com/inward/record.url?scp=80054721898&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80054721898&partnerID=8YFLogxK

U2 - 10.1021/ol202159x

DO - 10.1021/ol202159x

M3 - Article

C2 - 21899305

AN - SCOPUS:80054721898

VL - 13

SP - 5294

EP - 5297

JO - Organic Letters

JF - Organic Letters

SN - 1523-7060

IS - 19

ER -