Pyrrolidinone diterpenoid from Isodon excisus and inhibition of nitric oxide production in lipopolysaccharide-induced macrophage RAW264.7 cells

Seong Su Hong, Seon A. Lee, Nahyun Kim, Ji Sang Hwang, Xiang Hua Han, Mi Kyeong Lee, Jae Kyung Jung, Jin Tae Hong, Youngsoo Kim, Dongho Lee, Bang Yeon Hwang

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A new pyrrolidinone diterpenoid, excisusin F (1), was isolated from the aerial parts of Isodon excisus (Lamiaceae), together with four known compounds, and their structures were determined mainly by NMR (1D and 2D) and mass spectrometry. Excisusin F (1) and inflexarabdonin E (3) showed potent inhibitory effects of LPS-induced nitric oxide production in RAW264.7 cells with the IC50 value of 10.4 and 3.8 μM, respectively.

Original languageEnglish
Pages (from-to)1279-1281
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume21
Issue number4
DOIs
Publication statusPublished - 2011 Feb 15

Fingerprint

Isodon
Pyrrolidinones
Diterpenes
Macrophages
Lipopolysaccharides
Nitric Oxide
Lamiaceae
Inhibitory Concentration 50
Mass spectrometry
Mass Spectrometry
Nuclear magnetic resonance
Antennas
excisusin F

Keywords

  • Isodon excisus
  • Lamiaceae
  • Nitric oxide inhibitor
  • Pyrrolidinone diterpenoid

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry

Cite this

Pyrrolidinone diterpenoid from Isodon excisus and inhibition of nitric oxide production in lipopolysaccharide-induced macrophage RAW264.7 cells. / Hong, Seong Su; Lee, Seon A.; Kim, Nahyun; Hwang, Ji Sang; Han, Xiang Hua; Lee, Mi Kyeong; Jung, Jae Kyung; Hong, Jin Tae; Kim, Youngsoo; Lee, Dongho; Hwang, Bang Yeon.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 21, No. 4, 15.02.2011, p. 1279-1281.

Research output: Contribution to journalArticle

Hong, Seong Su ; Lee, Seon A. ; Kim, Nahyun ; Hwang, Ji Sang ; Han, Xiang Hua ; Lee, Mi Kyeong ; Jung, Jae Kyung ; Hong, Jin Tae ; Kim, Youngsoo ; Lee, Dongho ; Hwang, Bang Yeon. / Pyrrolidinone diterpenoid from Isodon excisus and inhibition of nitric oxide production in lipopolysaccharide-induced macrophage RAW264.7 cells. In: Bioorganic and Medicinal Chemistry Letters. 2011 ; Vol. 21, No. 4. pp. 1279-1281.
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AU - Hwang, Ji Sang

AU - Han, Xiang Hua

AU - Lee, Mi Kyeong

AU - Jung, Jae Kyung

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AU - Kim, Youngsoo

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