Pyrrolidinone diterpenoid from Isodon excisus and inhibition of nitric oxide production in lipopolysaccharide-induced macrophage RAW264.7 cells

Seong Su Hong; Seon A. Lee; Nahyun Kim; Ji Sang Hwang; Xiang Hua Han; Mi Kyeong Lee; Jae Kyung Jung; Jin Tae Hong; Youngsoo Kim; Dongho Lee; Bang Yeon Hwang

doi:10.1016/j.bmcl.2010.11.095

Pyrrolidinone diterpenoid from Isodon excisus and inhibition of nitric oxide production in lipopolysaccharide-induced macrophage RAW264.7 cells

Seong Su Hong, Seon A. Lee, Nahyun Kim, Ji Sang Hwang, Xiang Hua Han, Mi Kyeong Lee, Jae Kyung Jung, Jin Tae Hong, Youngsoo Kim, Dongho Lee, Bang Yeon Hwang

Department of Biosystems and Biotechnology

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

A new pyrrolidinone diterpenoid, excisusin F (1), was isolated from the aerial parts of Isodon excisus (Lamiaceae), together with four known compounds, and their structures were determined mainly by NMR (1D and 2D) and mass spectrometry. Excisusin F (1) and inflexarabdonin E (3) showed potent inhibitory effects of LPS-induced nitric oxide production in RAW264.7 cells with the IC₅₀ value of 10.4 and 3.8 μM, respectively.

Original language	English
Pages (from-to)	1279-1281
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	21
Issue number	4
DOIs	https://doi.org/10.1016/j.bmcl.2010.11.095
Publication status	Published - 2011 Feb 15

Keywords

Isodon excisus
Lamiaceae
Nitric oxide inhibitor
Pyrrolidinone diterpenoid

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2010.11.095

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Hong, S. S., Lee, S. A., Kim, N., Hwang, J. S., Han, X. H., Lee, M. K., Jung, J. K., Hong, J. T., Kim, Y., Lee, D., & Hwang, B. Y. (2011). Pyrrolidinone diterpenoid from Isodon excisus and inhibition of nitric oxide production in lipopolysaccharide-induced macrophage RAW264.7 cells. Bioorganic and Medicinal Chemistry Letters, 21(4), 1279-1281. https://doi.org/10.1016/j.bmcl.2010.11.095

Hong, SS, Lee, SA, Kim, N, Hwang, JS, Han, XH, Lee, MK, Jung, JK, Hong, JT, Kim, Y, Lee, D & Hwang, BY 2011, 'Pyrrolidinone diterpenoid from Isodon excisus and inhibition of nitric oxide production in lipopolysaccharide-induced macrophage RAW264.7 cells', Bioorganic and Medicinal Chemistry Letters, vol. 21, no. 4, pp. 1279-1281. https://doi.org/10.1016/j.bmcl.2010.11.095

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title = "Pyrrolidinone diterpenoid from Isodon excisus and inhibition of nitric oxide production in lipopolysaccharide-induced macrophage RAW264.7 cells",

abstract = "A new pyrrolidinone diterpenoid, excisusin F (1), was isolated from the aerial parts of Isodon excisus (Lamiaceae), together with four known compounds, and their structures were determined mainly by NMR (1D and 2D) and mass spectrometry. Excisusin F (1) and inflexarabdonin E (3) showed potent inhibitory effects of LPS-induced nitric oxide production in RAW264.7 cells with the IC50 value of 10.4 and 3.8 μM, respectively.",

keywords = "Isodon excisus, Lamiaceae, Nitric oxide inhibitor, Pyrrolidinone diterpenoid",

author = "Hong, {Seong Su} and Lee, {Seon A.} and Nahyun Kim and Hwang, {Ji Sang} and Han, {Xiang Hua} and Lee, {Mi Kyeong} and Jung, {Jae Kyung} and Hong, {Jin Tae} and Youngsoo Kim and Dongho Lee and Hwang, {Bang Yeon}",

note = "Funding Information: This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MEST) (MRC, 2010-0029480 ) and the grant of the Korean Ministry of Education, Science and Technology (The Regional Core Research Program/Chungbuk BIT Research-Oriented University Consortium). We thank the Korea Basic Science Institute for providing certain instruments used in this study.",

year = "2011",

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day = "15",

doi = "10.1016/j.bmcl.2010.11.095",

language = "English",

volume = "21",

pages = "1279--1281",

journal = "Bioorganic and Medicinal Chemistry Letters",

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T1 - Pyrrolidinone diterpenoid from Isodon excisus and inhibition of nitric oxide production in lipopolysaccharide-induced macrophage RAW264.7 cells

AU - Hong, Seong Su

AU - Lee, Seon A.

AU - Kim, Nahyun

AU - Hwang, Ji Sang

AU - Han, Xiang Hua

AU - Lee, Mi Kyeong

AU - Jung, Jae Kyung

AU - Hong, Jin Tae

AU - Kim, Youngsoo

AU - Lee, Dongho

AU - Hwang, Bang Yeon

N1 - Funding Information: This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MEST) (MRC, 2010-0029480 ) and the grant of the Korean Ministry of Education, Science and Technology (The Regional Core Research Program/Chungbuk BIT Research-Oriented University Consortium). We thank the Korea Basic Science Institute for providing certain instruments used in this study.

PY - 2011/2/15

Y1 - 2011/2/15

N2 - A new pyrrolidinone diterpenoid, excisusin F (1), was isolated from the aerial parts of Isodon excisus (Lamiaceae), together with four known compounds, and their structures were determined mainly by NMR (1D and 2D) and mass spectrometry. Excisusin F (1) and inflexarabdonin E (3) showed potent inhibitory effects of LPS-induced nitric oxide production in RAW264.7 cells with the IC50 value of 10.4 and 3.8 μM, respectively.

AB - A new pyrrolidinone diterpenoid, excisusin F (1), was isolated from the aerial parts of Isodon excisus (Lamiaceae), together with four known compounds, and their structures were determined mainly by NMR (1D and 2D) and mass spectrometry. Excisusin F (1) and inflexarabdonin E (3) showed potent inhibitory effects of LPS-induced nitric oxide production in RAW264.7 cells with the IC50 value of 10.4 and 3.8 μM, respectively.

KW - Isodon excisus

KW - Lamiaceae

KW - Nitric oxide inhibitor

KW - Pyrrolidinone diterpenoid

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DO - 10.1016/j.bmcl.2010.11.095

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AN - SCOPUS:79851508272

SN - 0960-894X

VL - 21

SP - 1279

EP - 1281

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 4

ER -

Pyrrolidinone diterpenoid from Isodon excisus and inhibition of nitric oxide production in lipopolysaccharide-induced macrophage RAW264.7 cells

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Keywords

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