Quantification of the wound healing using polarization-sensitive optical coherence tomography

Jung Taek Oh, Sang Won Lee, Youn Soo Kim, Ki Beom Suhr, Beop Min Kim

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

We use polarization-sensitive optical coherence tomography (PS-OCT) to monitor the wound healing process in vitro and in vivo, which are affected by various drugs. Five rabbit subjects are used for in vitro studies and another five are used for in vivo studies. The in vitro studies are conducted to compare the PS-OCT images with histopathology. For each subject, three biopsy lesions are created on each ear: one site is not treated (control); the second site is treated with sphingosylphosphorylcholine, which is expected to promote healing; and the last is administered with tetraacetylphytosphingosine, which negatively affects the healing process. Each site is examined with a PS-OCT system at 1, 4, 7, 10, and 14-days after wound generation. The variations of phase retardation values caused by the collagen morphology changes on wound sites are quantified for all cases. Our results suggest that PS-OCT may be a useful tool for visualization of collagen fiber regeneration and for quantification of various drug effects during the wound healing process.

Original languageEnglish
Article number041124
JournalJournal of biomedical optics
Volume11
Issue number4
DOIs
Publication statusPublished - 2006 Jul
Externally publishedYes

Keywords

  • Collagen fiber
  • PS-OCT
  • SPC
  • TAPS
  • Wound healing

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering

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