Quantitative analysis of diffusion-weighted magnetic resonance imaging of the pancreas: Usefulness in characterizing solid pancreatic masses

Soo Lee Seung, Ho Byun Jae, Beomjin Park, Ho Park Seong, Namkug Kim, Bumwoo Park, Kon Kim Jeong, Moon Gyu Lee

Research output: Contribution to journalArticle

128 Citations (Scopus)

Abstract

Purpose: To evaluate whether measurement of apparent diffusion coefficient (ADC) and pure diffusion coefficient (D) can help to characterize solid pancreatic masses. Materials and Methods: Diffusion-weighted MR imaging was performed in both a patient group (n = 71; pancreatic cancer [n = 47], mass-forming pancreatitis [n = 13], solid pseudopapillary neoplasm [n = 6], and neuroendocrine tumor [n = 5]) and a normal control group (n = 11) by applying three b-factors of 0, 500, and 1000 sec/mm2. ADC500, ADC1000, D (ADC using b = 500 and 1000 sec/mm2), and perfusion fraction (f, 1- exp [-500 sec/mm2 x (ADC500 - D)]) of normal pancreas, pancreatic cancer, and mass-forming pancreatitis were compared using the Kruskal-Wallis test. Receiver operating characteristic (ROC) analysis was performed to evaluate the diagnostic performance and optimal cutoff value of these parameters in differentiating pancreatic cancer from mass-forming pancreatitis. Results: Normal pancreas had significantly higher mean ADC500, ADC1000, and f than either pancreatic cancer (P < 0.001, < 0.001, and 0.004, respectively) or mass-forming pancreatitis (P < 0.001, < 0.001, and 0.002, respectively). ADC500, ADC1000, and D of mass-forming pancreatitis were significantly lower than those of pancreatic cancer (P = 0.002, 0.004, and 0.014, respectively). Sensitivities and specificities in the diagnosis of pancreatic cancer were 72.3% and 76.9% for ADC500, 87.2% and 69.2% for ADC1000, 87.2% and 61.5% for D, and 42.6% and 92.3% for f, respectively. Conclusion: Measurement of ADC and D may be helpful in differentiating pancreatic cancers from mass-forming pancreatitis.

Original languageEnglish
Pages (from-to)928-936
Number of pages9
JournalJournal of Magnetic Resonance Imaging
Volume28
Issue number4
DOIs
Publication statusPublished - 2008 Oct 1

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Diffusion Magnetic Resonance Imaging
Pancreatic Neoplasms
Pancreas
Pancreatitis
Neuroendocrine Tumors
ROC Curve
Perfusion
Sensitivity and Specificity
Control Groups

Keywords

  • Diffusion-weighted imaging
  • MRI
  • Pancreas

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Quantitative analysis of diffusion-weighted magnetic resonance imaging of the pancreas : Usefulness in characterizing solid pancreatic masses. / Seung, Soo Lee; Jae, Ho Byun; Park, Beomjin; Seong, Ho Park; Kim, Namkug; Park, Bumwoo; Jeong, Kon Kim; Lee, Moon Gyu.

In: Journal of Magnetic Resonance Imaging, Vol. 28, No. 4, 01.10.2008, p. 928-936.

Research output: Contribution to journalArticle

Seung, Soo Lee ; Jae, Ho Byun ; Park, Beomjin ; Seong, Ho Park ; Kim, Namkug ; Park, Bumwoo ; Jeong, Kon Kim ; Lee, Moon Gyu. / Quantitative analysis of diffusion-weighted magnetic resonance imaging of the pancreas : Usefulness in characterizing solid pancreatic masses. In: Journal of Magnetic Resonance Imaging. 2008 ; Vol. 28, No. 4. pp. 928-936.
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abstract = "Purpose: To evaluate whether measurement of apparent diffusion coefficient (ADC) and pure diffusion coefficient (D) can help to characterize solid pancreatic masses. Materials and Methods: Diffusion-weighted MR imaging was performed in both a patient group (n = 71; pancreatic cancer [n = 47], mass-forming pancreatitis [n = 13], solid pseudopapillary neoplasm [n = 6], and neuroendocrine tumor [n = 5]) and a normal control group (n = 11) by applying three b-factors of 0, 500, and 1000 sec/mm2. ADC500, ADC1000, D (ADC using b = 500 and 1000 sec/mm2), and perfusion fraction (f, 1- exp [-500 sec/mm2 x (ADC500 - D)]) of normal pancreas, pancreatic cancer, and mass-forming pancreatitis were compared using the Kruskal-Wallis test. Receiver operating characteristic (ROC) analysis was performed to evaluate the diagnostic performance and optimal cutoff value of these parameters in differentiating pancreatic cancer from mass-forming pancreatitis. Results: Normal pancreas had significantly higher mean ADC500, ADC1000, and f than either pancreatic cancer (P < 0.001, < 0.001, and 0.004, respectively) or mass-forming pancreatitis (P < 0.001, < 0.001, and 0.002, respectively). ADC500, ADC1000, and D of mass-forming pancreatitis were significantly lower than those of pancreatic cancer (P = 0.002, 0.004, and 0.014, respectively). Sensitivities and specificities in the diagnosis of pancreatic cancer were 72.3{\%} and 76.9{\%} for ADC500, 87.2{\%} and 69.2{\%} for ADC1000, 87.2{\%} and 61.5{\%} for D, and 42.6{\%} and 92.3{\%} for f, respectively. Conclusion: Measurement of ADC and D may be helpful in differentiating pancreatic cancers from mass-forming pancreatitis.",
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T2 - Usefulness in characterizing solid pancreatic masses

AU - Seung, Soo Lee

AU - Jae, Ho Byun

AU - Park, Beomjin

AU - Seong, Ho Park

AU - Kim, Namkug

AU - Park, Bumwoo

AU - Jeong, Kon Kim

AU - Lee, Moon Gyu

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N2 - Purpose: To evaluate whether measurement of apparent diffusion coefficient (ADC) and pure diffusion coefficient (D) can help to characterize solid pancreatic masses. Materials and Methods: Diffusion-weighted MR imaging was performed in both a patient group (n = 71; pancreatic cancer [n = 47], mass-forming pancreatitis [n = 13], solid pseudopapillary neoplasm [n = 6], and neuroendocrine tumor [n = 5]) and a normal control group (n = 11) by applying three b-factors of 0, 500, and 1000 sec/mm2. ADC500, ADC1000, D (ADC using b = 500 and 1000 sec/mm2), and perfusion fraction (f, 1- exp [-500 sec/mm2 x (ADC500 - D)]) of normal pancreas, pancreatic cancer, and mass-forming pancreatitis were compared using the Kruskal-Wallis test. Receiver operating characteristic (ROC) analysis was performed to evaluate the diagnostic performance and optimal cutoff value of these parameters in differentiating pancreatic cancer from mass-forming pancreatitis. Results: Normal pancreas had significantly higher mean ADC500, ADC1000, and f than either pancreatic cancer (P < 0.001, < 0.001, and 0.004, respectively) or mass-forming pancreatitis (P < 0.001, < 0.001, and 0.002, respectively). ADC500, ADC1000, and D of mass-forming pancreatitis were significantly lower than those of pancreatic cancer (P = 0.002, 0.004, and 0.014, respectively). Sensitivities and specificities in the diagnosis of pancreatic cancer were 72.3% and 76.9% for ADC500, 87.2% and 69.2% for ADC1000, 87.2% and 61.5% for D, and 42.6% and 92.3% for f, respectively. Conclusion: Measurement of ADC and D may be helpful in differentiating pancreatic cancers from mass-forming pancreatitis.

AB - Purpose: To evaluate whether measurement of apparent diffusion coefficient (ADC) and pure diffusion coefficient (D) can help to characterize solid pancreatic masses. Materials and Methods: Diffusion-weighted MR imaging was performed in both a patient group (n = 71; pancreatic cancer [n = 47], mass-forming pancreatitis [n = 13], solid pseudopapillary neoplasm [n = 6], and neuroendocrine tumor [n = 5]) and a normal control group (n = 11) by applying three b-factors of 0, 500, and 1000 sec/mm2. ADC500, ADC1000, D (ADC using b = 500 and 1000 sec/mm2), and perfusion fraction (f, 1- exp [-500 sec/mm2 x (ADC500 - D)]) of normal pancreas, pancreatic cancer, and mass-forming pancreatitis were compared using the Kruskal-Wallis test. Receiver operating characteristic (ROC) analysis was performed to evaluate the diagnostic performance and optimal cutoff value of these parameters in differentiating pancreatic cancer from mass-forming pancreatitis. Results: Normal pancreas had significantly higher mean ADC500, ADC1000, and f than either pancreatic cancer (P < 0.001, < 0.001, and 0.004, respectively) or mass-forming pancreatitis (P < 0.001, < 0.001, and 0.002, respectively). ADC500, ADC1000, and D of mass-forming pancreatitis were significantly lower than those of pancreatic cancer (P = 0.002, 0.004, and 0.014, respectively). Sensitivities and specificities in the diagnosis of pancreatic cancer were 72.3% and 76.9% for ADC500, 87.2% and 69.2% for ADC1000, 87.2% and 61.5% for D, and 42.6% and 92.3% for f, respectively. Conclusion: Measurement of ADC and D may be helpful in differentiating pancreatic cancers from mass-forming pancreatitis.

KW - Diffusion-weighted imaging

KW - MRI

KW - Pancreas

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