Quantitative determination of nicotine in a PDMS microfluidic channel using surface enhanced Raman spectroscopy

Jaehyun Jung, Jaebum Choo, Joong Kim Duck, Sang Hoon Lee

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Rapid and highly sensitive determination of nicotine in a PDMS microfluidic channel was investigated using surface enhanced Raman spectroscopy (SERS). A three-dimensional PDMS microfluidic channel was fabricated for this purpose. This channel shows a high mixing efficiency because the transverse and vertical dispersions of the fluid occur simultaneously through the upper and lower zig zag-type blocks. A higher efficiency of mixing could also be obtained by splitting each of the confluent streams into two sub-streams that then joined and recombined. The SERS signal was measured after nicotine molecules were effectively adsorbed onto silver nanoparticles by passing through the three-dimensional channel. A quantitative analysis of nicotine was performed based on the measured peak area at 1030 cm-1. The detection limit was estimated to be below 0.1 ppm. In this work, the SERS detection, in combination with a PDMS microfluidic channel, has been applied to the quantitative analysis of nicotine in aqueous solution. Compared to the other conventional analytical methods, the detection sensitivity was enhanced up to several orders of magnitude.

Original languageEnglish
Pages (from-to)277-280
Number of pages4
JournalBulletin of the Korean Chemical Society
Volume27
Issue number2
Publication statusPublished - 2006 Feb 20

Keywords

  • Microfluidic chip
  • Nicotine
  • Quantitative analysis
  • Surface enhanced Raman spectroscopy

ASJC Scopus subject areas

  • Chemistry(all)

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