Quantitative evaluation of parkinsonian rigidity during intra-operative deep brain stimulation

Yuri Kwon, Sang Hoon Park, Ji Won Kim, Yeji Ho, Hyeong Min Jeon, Min Jung Bang, Seong Beom Koh, Jong Hyun Kim, Gwang Moon Eom

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

This study aims at the quantification of fine change in parkinsonian rigidity at the wrist during deep brain stimulation (DBS) using a portable measurement system and objective mechanical measures. The rigidity of fourteen limbs was evaluated during DBS surgery. The resistive torque to imposed movement was measured for every setting where a reduction in rigidity was perceived by a neurologist. Quantitative mechanical measures derived from experimental data included viscoelastic properties, work, impulse and mechanical impedance. Most mechanical measures could discriminate the optimal setting from baseline (electrode at stereotactic initial position without electrical stimulation) and the highest significance was achieved by viscous damping constant (p<0.001). Spearman correlation coefficients between mechanical measures and clinical score for multiple settings (averaged for 14 limbs) were 0.51-0.77 and the best correlation was shown for viscosity (p=0.77±0.22). The results suggest that intraoperative quantification of rigidity during DBS surgery is possible with the suggested system and measures, which would be helpful for the adjustment of electrode position and stimulation parameters.

Original languageEnglish
Pages (from-to)2273-2281
Number of pages9
JournalBio-Medical Materials and Engineering
Volume24
Issue number6
DOIs
Publication statusPublished - 2014 Jan 1

Fingerprint

Rigidity
Brain
Surgery
Electrodes
Torque
Damping
Viscosity

Keywords

  • DBS surgery
  • Intraoperative
  • Parkinson's disease
  • Quantification
  • Rigidity

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering

Cite this

Kwon, Y., Park, S. H., Kim, J. W., Ho, Y., Jeon, H. M., Bang, M. J., ... Eom, G. M. (2014). Quantitative evaluation of parkinsonian rigidity during intra-operative deep brain stimulation. Bio-Medical Materials and Engineering, 24(6), 2273-2281. https://doi.org/10.3233/BME-141040

Quantitative evaluation of parkinsonian rigidity during intra-operative deep brain stimulation. / Kwon, Yuri; Park, Sang Hoon; Kim, Ji Won; Ho, Yeji; Jeon, Hyeong Min; Bang, Min Jung; Koh, Seong Beom; Kim, Jong Hyun; Eom, Gwang Moon.

In: Bio-Medical Materials and Engineering, Vol. 24, No. 6, 01.01.2014, p. 2273-2281.

Research output: Contribution to journalArticle

Kwon, Yuri ; Park, Sang Hoon ; Kim, Ji Won ; Ho, Yeji ; Jeon, Hyeong Min ; Bang, Min Jung ; Koh, Seong Beom ; Kim, Jong Hyun ; Eom, Gwang Moon. / Quantitative evaluation of parkinsonian rigidity during intra-operative deep brain stimulation. In: Bio-Medical Materials and Engineering. 2014 ; Vol. 24, No. 6. pp. 2273-2281.
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