Quantitative evaluation of parkinsonian rigidity during intra-operative deep brain stimulation

Yuri Kwon, Sang Hoon Park, Ji Won Kim, Yeji Ho, Hyeong Min Jeon, Min Jung Bang, Seong Beom Koh, Jong Hyun Kim, Gwang Moon Eom

    Research output: Contribution to journalArticlepeer-review

    17 Citations (Scopus)

    Abstract

    This study aims at the quantification of fine change in parkinsonian rigidity at the wrist during deep brain stimulation (DBS) using a portable measurement system and objective mechanical measures. The rigidity of fourteen limbs was evaluated during DBS surgery. The resistive torque to imposed movement was measured for every setting where a reduction in rigidity was perceived by a neurologist. Quantitative mechanical measures derived from experimental data included viscoelastic properties, work, impulse and mechanical impedance. Most mechanical measures could discriminate the optimal setting from baseline (electrode at stereotactic initial position without electrical stimulation) and the highest significance was achieved by viscous damping constant (p<0.001). Spearman correlation coefficients between mechanical measures and clinical score for multiple settings (averaged for 14 limbs) were 0.51-0.77 and the best correlation was shown for viscosity (p=0.77±0.22). The results suggest that intraoperative quantification of rigidity during DBS surgery is possible with the suggested system and measures, which would be helpful for the adjustment of electrode position and stimulation parameters.

    Original languageEnglish
    Pages (from-to)2273-2281
    Number of pages9
    JournalBio-Medical Materials and Engineering
    Volume24
    Issue number6
    DOIs
    Publication statusPublished - 2014

    Keywords

    • DBS surgery
    • Intraoperative
    • Parkinson's disease
    • Quantification
    • Rigidity

    ASJC Scopus subject areas

    • Biomaterials
    • Biomedical Engineering

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