Quantitative image analysis of hair follicles in alopecia areata

Il-Hwan Kim, Jo Ho-Yeon, Cho Chang Geun, Hyan Chul Choi, Chil Hwan Oh

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Abstract

We took biopsies from similar sites on the scalps of normal controls, normal looking and hair loss areas of patients with alopecia areata. The specimens were sectioned serially and horizontally. We measured morphological parameters, such as the diameter of the hair shaft, the thickness of the inner root sheath, the diameter of the outer root sheath, the irregularity of the outer root sheath and the ratio between the diameters of the hair shaft and the outer root sheath, using a computerized image analysis system. There were significant differences in 5 parameters between hair loss areas and normal controls. The proportions of vellus and telogen hair were significantly higher in the areata areas than in the controls. The 5 morphological parameters and most quantitative-measured parameters of normal- looking areas from patients with alopecia values intermediate between the other groups.

Original languageEnglish
Pages (from-to)214-216
Number of pages3
JournalActa Dermato-Venereologica
Volume79
Issue number3
DOIs
Publication statusPublished - 1999 Jun 9

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Keywords

  • Alopecia areata
  • Transverse section image analysis

ASJC Scopus subject areas

  • Dermatology

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