Quercetin intake, MATE1 polymorphism, and metabolic syndrome in Korean population: Hallym aging study

Jung Eun Lee, Hye Won Park, Jae Kyung Lee, Bo Ram Mok, Hae Jeung Lee, Sung-Joon Lee, Dong Hyun Kim

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Multidrug and toxic compound extrusion transporter-1 (MATE1) is a quercetin transporter. We examined the associations of quercetin intake and polymorphism of MATE1 in relation to metabolic syndrome (MetS) in Hallym Aging Study. Quercetin intake and the measurements for MetS were assessed in 2004. Six tagging single nucleotide polymorphisms (SNPs) at MATE1 gene were genotyped in 428 Korean adults in 2012. We found a lower prevalence of MetS with quercetin intake; compared to the lowest quartile, odds ratios (ORs, 95% confidence intervals; CIs) were 0.44 (0.24-0.84) for the 3rd quartile. Individuals with the minor allele of MATE1, rs2453589, tended to have a lower prevalence of MetS compared to those with the major allele (OR=0.69; CI=0.36-1.34). However, interactions between quercetin intake and six MATE1 polymorphisms in relation to MetS were not significant (p for interaction ≥0.37). In conclusion, intake of quercetin was associated with MetS in Korean populations.

Original languageEnglish
Pages (from-to)1783-1788
Number of pages6
JournalFood Science and Biotechnology
Issue number6
Publication statusPublished - 2016 Dec 1



  • flavonoid
  • metabolic syndrome
  • multidrug and toxic compound extrusion transporter-1
  • quercetin

ASJC Scopus subject areas

  • Biotechnology
  • Food Science
  • Applied Microbiology and Biotechnology

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