Quinolone alkaloids from evodiae fructus and their inhibitory effects on monoamine oxidase

Hua Han Xiang, Su Hong Seong, Dongho Lee, Joon Lee Jung, Soon Lee Moon, Dong Cheul Moon, Kun Han, Ki Wan Oh, Koo Lee Myung, Seup Ro Jai, Yeon Hwang Bang

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

1-Methyl-2-undecyl-4(1H)-quinolone (1) was previously isolated as a selective MAO-B inhibitor from the Evodiae Fructus. Further bioassay-guided purification led to the identification of five known quinolone alkaloids, 1-methyl-2-nonyl-4(1H)-quinolone (2), 1-methyl-2-[(Z)-6-undecenyl]-4(1H)- quinolone (3), evocarpine (4), 1-methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)- quinolone (5), and dihydroevocarpine (6). All the isolates showed more potent inhibitory effects against MAO-B compared to MAO-A. The most MAO-B selective compound 5 among the isolates inhibited MAO-B in a competitive manner, according to kinetic analyses by Lineweaver-Burk reciprocal plots.

Original languageEnglish
Pages (from-to)397-401
Number of pages5
JournalArchives of Pharmacal Research
Volume30
Issue number4
Publication statusPublished - 2007 Apr 30

Fingerprint

Evodia
Quinolones
Monoamine Oxidase
Alkaloids
4-Quinolones
Monoamine Oxidase Inhibitors
Bioassay
Biological Assay
Purification
Kinetics

Keywords

  • Evodia rutaecarpa
  • Evodiae fructus
  • Monoamine oxidase inhibitor
  • Quinolone alkaloid
  • Rutaceae

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology

Cite this

Xiang, H. H., Seong, S. H., Lee, D., Jung, J. L., Moon, S. L., Moon, D. C., ... Bang, Y. H. (2007). Quinolone alkaloids from evodiae fructus and their inhibitory effects on monoamine oxidase. Archives of Pharmacal Research, 30(4), 397-401.

Quinolone alkaloids from evodiae fructus and their inhibitory effects on monoamine oxidase. / Xiang, Hua Han; Seong, Su Hong; Lee, Dongho; Jung, Joon Lee; Moon, Soon Lee; Moon, Dong Cheul; Han, Kun; Oh, Ki Wan; Myung, Koo Lee; Jai, Seup Ro; Bang, Yeon Hwang.

In: Archives of Pharmacal Research, Vol. 30, No. 4, 30.04.2007, p. 397-401.

Research output: Contribution to journalArticle

Xiang, HH, Seong, SH, Lee, D, Jung, JL, Moon, SL, Moon, DC, Han, K, Oh, KW, Myung, KL, Jai, SR & Bang, YH 2007, 'Quinolone alkaloids from evodiae fructus and their inhibitory effects on monoamine oxidase', Archives of Pharmacal Research, vol. 30, no. 4, pp. 397-401.
Xiang, Hua Han ; Seong, Su Hong ; Lee, Dongho ; Jung, Joon Lee ; Moon, Soon Lee ; Moon, Dong Cheul ; Han, Kun ; Oh, Ki Wan ; Myung, Koo Lee ; Jai, Seup Ro ; Bang, Yeon Hwang. / Quinolone alkaloids from evodiae fructus and their inhibitory effects on monoamine oxidase. In: Archives of Pharmacal Research. 2007 ; Vol. 30, No. 4. pp. 397-401.
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