Quinolone alkaloids from evodiae fructus and their inhibitory effects on monoamine oxidase

Hua Han Xiang, Su Hong Seong, Dongho Lee, Joon Lee Jung, Soon Lee Moon, Dong Cheul Moon, Kun Han, Ki Wan Oh, Koo Lee Myung, Seup Ro Jai, Yeon Hwang Bang

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

1-Methyl-2-undecyl-4(1H)-quinolone (1) was previously isolated as a selective MAO-B inhibitor from the Evodiae Fructus. Further bioassay-guided purification led to the identification of five known quinolone alkaloids, 1-methyl-2-nonyl-4(1H)-quinolone (2), 1-methyl-2-[(Z)-6-undecenyl]-4(1H)- quinolone (3), evocarpine (4), 1-methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)- quinolone (5), and dihydroevocarpine (6). All the isolates showed more potent inhibitory effects against MAO-B compared to MAO-A. The most MAO-B selective compound 5 among the isolates inhibited MAO-B in a competitive manner, according to kinetic analyses by Lineweaver-Burk reciprocal plots.

Original languageEnglish
Pages (from-to)397-401
Number of pages5
JournalArchives of pharmacal research
Volume30
Issue number4
Publication statusPublished - 2007 Apr 30

Keywords

  • Evodia rutaecarpa
  • Evodiae fructus
  • Monoamine oxidase inhibitor
  • Quinolone alkaloid
  • Rutaceae

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry

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