Quinolone alkaloids with inhibitory activity against nuclear factor of activated T cells from the fruits of Evodia rutaecarpa

Hui Zi Jin, Jeong Hyung Lee, Dongho Lee, Hyun Sun Lee, Young Soo Hong, Young Ho Kim, Jung Joon Lee

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

Nine quinolone alkaloids (1 - 9) from the fruits of Evodia rutaecarpa were investigated for their inhibitory activity on nuclear factor of activated T cells (NFAT)-dependent transcription in comparison with nuclear factor (NF)-κB-dependent transcription using a reporter gene assay. These alkaloids showed inhibitory effects against NFAT activity, with IC50 values between 0.91 μM and 15.91 μM. Of the N-methylated quinolones, the longer aliphatic side chain at the quinolone ring showed stronger inhibition of NFAT activity. These N-methylated compounds showed comparable inhibitory effects against NF-κB activity. However, quinolone alkaloids without the N-methyl group showed a more selective inhibition of NFAT activity.

Original languageEnglish
Pages (from-to)926-928
Number of pages3
JournalBiological and Pharmaceutical Bulletin
Volume27
Issue number6
DOIs
Publication statusPublished - 2004 Jun

Keywords

  • Evodia rutaecarpa
  • Nuclear factor activated T cell
  • Nuclear factor-κB
  • Quinolone alkaloid

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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