Quorum sensing inhibitors as antipathogens: biotechnological applications

Vipin Chandra Kalia, Sanjay K.S. Patel, Yun Chan Kang, Jung Kul Lee

Research output: Contribution to journalReview article

45 Citations (Scopus)

Abstract

The mechanisms through which microbes communicate using signal molecules has inspired a great deal of research. Microbes use this exchange of information, known as quorum sensing (QS), to initiate and perpetuate infectious diseases in eukaryotic organisms, evading the eukaryotic defense system by multiplying and expressing their pathogenicity through QS regulation. The major issue to arise from such networks is increased bacterial resistance to antibiotics, resulting from QS-dependent mediation of the formation of biofilm, the induction of efflux pumps, and the production of antibiotics. QS inhibitors (QSIs) of diverse origins have been shown to act as potential antipathogens. In this review, we focus on the use of QSIs to counter diseases in humans as well as plants and animals of economic importance. We also discuss the challenges encountered in the potential applications of QSIs.

Original languageEnglish
Pages (from-to)68-90
Number of pages23
JournalBiotechnology Advances
Volume37
Issue number1
DOIs
Publication statusPublished - 2019 Jan 1

Keywords

  • Antipathogens
  • Aquaculture
  • Biofilm
  • Human health
  • Infectious diseases
  • Inhibitors
  • Pathogens
  • Quorum sensing

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

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