Radiation-induced brain structural and functional abnormalities in presymptomatic phase and outcome prediction

Zhongxiang Ding, Han Zhang, Xiao Fei Lv, Fei Xie, Lizhi Liu, Shijun Qiu, Li Li, Dinggang Shen

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Radiation therapy, a major method of treatment for brain cancer, may cause severe brain injuries after many years. We used a rare and unique cohort of nasopharyngeal carcinoma patients with normal-appearing brains to study possible early irradiation injury in its presymptomatic phase before severe, irreversible necrosis happens. The aim is to detect any structural or functional imaging biomarker that is sensitive to early irradiation injury, and to understand the recovery and progression of irradiation injury that can shed light on outcome prediction for early clinical intervention. We found an acute increase in local brain activity that is followed by extensive reductions in such activity in the temporal lobe and significant loss of functional connectivity in a distributed, large-scale, high-level cognitive function-related brain network. Intriguingly, these radiosensitive functional alterations were found to be fully or partially recoverable. In contrast, progressive late disruptions to the integrity of the related far-end white matter structure began to be significant after one year. Importantly, early increased local brain functional activity was predictive of severe later temporal lobe necrosis. Based on these findings, we proposed a dynamic, multifactorial model for radiation injury and another preventive model for timely clinical intervention. Hum Brain Mapp 39:407–427, 2018.

Original languageEnglish
Pages (from-to)407-427
Number of pages21
JournalHuman Brain Mapping
Volume39
Issue number1
DOIs
Publication statusPublished - 2018 Jan 1

Fingerprint

Radiation
Brain
Temporal Lobe
Wounds and Injuries
Necrosis
Radiation Injuries
Brain Neoplasms
Brain Injuries
Cognition
Radiotherapy
Biomarkers
Therapeutics

Keywords

  • amplitude of low-frequency fluctuations
  • diffusion tensor imaging
  • functional connectivity
  • functional magnetic resonance imaging
  • irradiation injury
  • nasopharyngeal carcinoma
  • prognosis
  • radiation therapy
  • resting state
  • structural connectivity

ASJC Scopus subject areas

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology

Cite this

Radiation-induced brain structural and functional abnormalities in presymptomatic phase and outcome prediction. / Ding, Zhongxiang; Zhang, Han; Lv, Xiao Fei; Xie, Fei; Liu, Lizhi; Qiu, Shijun; Li, Li; Shen, Dinggang.

In: Human Brain Mapping, Vol. 39, No. 1, 01.01.2018, p. 407-427.

Research output: Contribution to journalArticle

Ding, Zhongxiang ; Zhang, Han ; Lv, Xiao Fei ; Xie, Fei ; Liu, Lizhi ; Qiu, Shijun ; Li, Li ; Shen, Dinggang. / Radiation-induced brain structural and functional abnormalities in presymptomatic phase and outcome prediction. In: Human Brain Mapping. 2018 ; Vol. 39, No. 1. pp. 407-427.
@article{cf2aa844c7b84a6babf165369f4c3c7d,
title = "Radiation-induced brain structural and functional abnormalities in presymptomatic phase and outcome prediction",
abstract = "Radiation therapy, a major method of treatment for brain cancer, may cause severe brain injuries after many years. We used a rare and unique cohort of nasopharyngeal carcinoma patients with normal-appearing brains to study possible early irradiation injury in its presymptomatic phase before severe, irreversible necrosis happens. The aim is to detect any structural or functional imaging biomarker that is sensitive to early irradiation injury, and to understand the recovery and progression of irradiation injury that can shed light on outcome prediction for early clinical intervention. We found an acute increase in local brain activity that is followed by extensive reductions in such activity in the temporal lobe and significant loss of functional connectivity in a distributed, large-scale, high-level cognitive function-related brain network. Intriguingly, these radiosensitive functional alterations were found to be fully or partially recoverable. In contrast, progressive late disruptions to the integrity of the related far-end white matter structure began to be significant after one year. Importantly, early increased local brain functional activity was predictive of severe later temporal lobe necrosis. Based on these findings, we proposed a dynamic, multifactorial model for radiation injury and another preventive model for timely clinical intervention. Hum Brain Mapp 39:407–427, 2018.",
keywords = "amplitude of low-frequency fluctuations, diffusion tensor imaging, functional connectivity, functional magnetic resonance imaging, irradiation injury, nasopharyngeal carcinoma, prognosis, radiation therapy, resting state, structural connectivity",
author = "Zhongxiang Ding and Han Zhang and Lv, {Xiao Fei} and Fei Xie and Lizhi Liu and Shijun Qiu and Li Li and Dinggang Shen",
year = "2018",
month = "1",
day = "1",
doi = "10.1002/hbm.23852",
language = "English",
volume = "39",
pages = "407--427",
journal = "Human Brain Mapping",
issn = "1065-9471",
publisher = "Wiley-Liss Inc.",
number = "1",

}

TY - JOUR

T1 - Radiation-induced brain structural and functional abnormalities in presymptomatic phase and outcome prediction

AU - Ding, Zhongxiang

AU - Zhang, Han

AU - Lv, Xiao Fei

AU - Xie, Fei

AU - Liu, Lizhi

AU - Qiu, Shijun

AU - Li, Li

AU - Shen, Dinggang

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Radiation therapy, a major method of treatment for brain cancer, may cause severe brain injuries after many years. We used a rare and unique cohort of nasopharyngeal carcinoma patients with normal-appearing brains to study possible early irradiation injury in its presymptomatic phase before severe, irreversible necrosis happens. The aim is to detect any structural or functional imaging biomarker that is sensitive to early irradiation injury, and to understand the recovery and progression of irradiation injury that can shed light on outcome prediction for early clinical intervention. We found an acute increase in local brain activity that is followed by extensive reductions in such activity in the temporal lobe and significant loss of functional connectivity in a distributed, large-scale, high-level cognitive function-related brain network. Intriguingly, these radiosensitive functional alterations were found to be fully or partially recoverable. In contrast, progressive late disruptions to the integrity of the related far-end white matter structure began to be significant after one year. Importantly, early increased local brain functional activity was predictive of severe later temporal lobe necrosis. Based on these findings, we proposed a dynamic, multifactorial model for radiation injury and another preventive model for timely clinical intervention. Hum Brain Mapp 39:407–427, 2018.

AB - Radiation therapy, a major method of treatment for brain cancer, may cause severe brain injuries after many years. We used a rare and unique cohort of nasopharyngeal carcinoma patients with normal-appearing brains to study possible early irradiation injury in its presymptomatic phase before severe, irreversible necrosis happens. The aim is to detect any structural or functional imaging biomarker that is sensitive to early irradiation injury, and to understand the recovery and progression of irradiation injury that can shed light on outcome prediction for early clinical intervention. We found an acute increase in local brain activity that is followed by extensive reductions in such activity in the temporal lobe and significant loss of functional connectivity in a distributed, large-scale, high-level cognitive function-related brain network. Intriguingly, these radiosensitive functional alterations were found to be fully or partially recoverable. In contrast, progressive late disruptions to the integrity of the related far-end white matter structure began to be significant after one year. Importantly, early increased local brain functional activity was predictive of severe later temporal lobe necrosis. Based on these findings, we proposed a dynamic, multifactorial model for radiation injury and another preventive model for timely clinical intervention. Hum Brain Mapp 39:407–427, 2018.

KW - amplitude of low-frequency fluctuations

KW - diffusion tensor imaging

KW - functional connectivity

KW - functional magnetic resonance imaging

KW - irradiation injury

KW - nasopharyngeal carcinoma

KW - prognosis

KW - radiation therapy

KW - resting state

KW - structural connectivity

UR - http://www.scopus.com/inward/record.url?scp=85037069677&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85037069677&partnerID=8YFLogxK

U2 - 10.1002/hbm.23852

DO - 10.1002/hbm.23852

M3 - Article

C2 - 29058342

AN - SCOPUS:85037069677

VL - 39

SP - 407

EP - 427

JO - Human Brain Mapping

JF - Human Brain Mapping

SN - 1065-9471

IS - 1

ER -