Radiation safety issues in Y-90 microsphere selective hepatic radioembolization therapy: Possible radiation exposure from the patients

Young Chul Kim, Yun Hwan Kim, Soon Ho Uhm, Yeon Seok Seo, Eun Kyung Park, Sun Young Oh, Eugene Jeong, Sinae Lee, Jae-Gol Choe

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Purpose: The purpose of this study was to estimate the possible external radiation dose to other individuals from patients treated with Y-90 resin microspheres for unresectable hepatocellular carcinoma. Methods: We designed the study prospectively to estimate the possible radiation dose to other individuals from patients who had been treated with Y-90 microspheres for unresectable hepatocellular carcinoma. We estimated the total effective dose equivalent (TEDE) using two methods: 'theoretical' TEDEs according to the administered activity and 'measured' TEDE based on the 'measured' ambient radiation exposure rate. We compared the results from each method to determine when we can release patients from confinement at the earliest time complying with the patient release criteria. Results: A total of 20 administrations of Y-90 resin microspheres were done in 18 patients. The average administered activity was 1.2±0.77 (0.28-2.97) GBq. The 'theoretical' TEDEs were in the range of 0.8-10 μSv. The 'measured' TEDEs were in the range of 2.31-185 μSv. The measured TEDEs tend to be higher than the theoretical TEDEs. The values of theoretical and measured TEDE were both far less than 1 mSv, the upper limit at which the licensee can release a patient without any written documents. Conclusion: The effective dose equivalent caused by the Y-90 microsphere administered patient is very low. It is safe in terms of radiation safety to the other individuals when Y-90 microsphere radioembolization therapy is done with dose less than 3 GBq. Because the measured TEDE tends to be higher than the theoretical TEDE, it is recommended to use 'measured' TEDE for determining patient release.

Original languageEnglish
Pages (from-to)252-260
Number of pages9
JournalNuclear Medicine and Molecular Imaging
Volume44
Issue number4
DOIs
Publication statusPublished - 2010 Dec 1

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Microspheres
Radiation
Safety
Liver
Therapeutics
Hepatocellular Carcinoma
Radiation Exposure

Keywords

  • Hepatocellular carcinoma
  • Liver tumor
  • Radiation safety
  • Selective hepatic radio-embolization therapy
  • Y-90 microsphere

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Radiation safety issues in Y-90 microsphere selective hepatic radioembolization therapy : Possible radiation exposure from the patients. / Kim, Young Chul; Kim, Yun Hwan; Uhm, Soon Ho; Seo, Yeon Seok; Park, Eun Kyung; Oh, Sun Young; Jeong, Eugene; Lee, Sinae; Choe, Jae-Gol.

In: Nuclear Medicine and Molecular Imaging, Vol. 44, No. 4, 01.12.2010, p. 252-260.

Research output: Contribution to journalArticle

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abstract = "Purpose: The purpose of this study was to estimate the possible external radiation dose to other individuals from patients treated with Y-90 resin microspheres for unresectable hepatocellular carcinoma. Methods: We designed the study prospectively to estimate the possible radiation dose to other individuals from patients who had been treated with Y-90 microspheres for unresectable hepatocellular carcinoma. We estimated the total effective dose equivalent (TEDE) using two methods: 'theoretical' TEDEs according to the administered activity and 'measured' TEDE based on the 'measured' ambient radiation exposure rate. We compared the results from each method to determine when we can release patients from confinement at the earliest time complying with the patient release criteria. Results: A total of 20 administrations of Y-90 resin microspheres were done in 18 patients. The average administered activity was 1.2±0.77 (0.28-2.97) GBq. The 'theoretical' TEDEs were in the range of 0.8-10 μSv. The 'measured' TEDEs were in the range of 2.31-185 μSv. The measured TEDEs tend to be higher than the theoretical TEDEs. The values of theoretical and measured TEDE were both far less than 1 mSv, the upper limit at which the licensee can release a patient without any written documents. Conclusion: The effective dose equivalent caused by the Y-90 microsphere administered patient is very low. It is safe in terms of radiation safety to the other individuals when Y-90 microsphere radioembolization therapy is done with dose less than 3 GBq. Because the measured TEDE tends to be higher than the theoretical TEDE, it is recommended to use 'measured' TEDE for determining patient release.",
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