Radio frequency-mediated local thermotherapy for destruction of pancreatic tumors using Ni-Au core-shell nanowires

Xiaoping Hopkins, Waqas Amin Gill, Rosemarie Kringel, Guankui Wang, Jamie Hass, Suresh Acharya, Jungrae Park, In Tak Jeon, Boo Hyun An, Ji Sung Lee, Jong Eun Ryu, Rod Hill, David McIlroy, Young-geun Kim, Daniel S. Choi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We present a novel method of radio frequency (RF)-mediated thermotherapy in tumors by remotely heating nickel (Ni)-gold (Au) core-shell nanowires (CSNWs). Ectopic pancreatic tumors were developed in nude mice to evaluate the thermotherapeutic effects on tumor progression. Tumor ablation was produced by RF-mediated thermotherapy via activation of the paramagnetic properties of the Ni-Au CSNWs. Histopathology demonstrated that heat generated by RF irradiation caused significant cellular death with pyknotic nuclei and nuclear fragmentation dispersed throughout the tumors. These preliminary results suggest that thermotherapy ablation induced via RF activation of nanowires provides a potential alternative therapy for cancer treatment.

Original languageEnglish
Article number03LT01
JournalNanotechnology
Volume28
Issue number3
DOIs
Publication statusPublished - 2017 Jan 20

Fingerprint

Nanowires
Induced Hyperthermia
Nickel
Radio
Tumors
Neoplasms
Ablation
Chemical activation
Oncology
Gold
Complementary Therapies
Nude Mice
Heating
Irradiation
Hot Temperature

Keywords

  • cancer
  • magnetic core-shell nanowire
  • RF radiation
  • RF-mediated thermotherapy

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering
  • Electrical and Electronic Engineering

Cite this

Hopkins, X., Gill, W. A., Kringel, R., Wang, G., Hass, J., Acharya, S., ... Choi, D. S. (2017). Radio frequency-mediated local thermotherapy for destruction of pancreatic tumors using Ni-Au core-shell nanowires. Nanotechnology, 28(3), [03LT01]. https://doi.org/10.1088/1361-6528/28/3/03LT01

Radio frequency-mediated local thermotherapy for destruction of pancreatic tumors using Ni-Au core-shell nanowires. / Hopkins, Xiaoping; Gill, Waqas Amin; Kringel, Rosemarie; Wang, Guankui; Hass, Jamie; Acharya, Suresh; Park, Jungrae; Jeon, In Tak; An, Boo Hyun; Lee, Ji Sung; Ryu, Jong Eun; Hill, Rod; McIlroy, David; Kim, Young-geun; Choi, Daniel S.

In: Nanotechnology, Vol. 28, No. 3, 03LT01, 20.01.2017.

Research output: Contribution to journalArticle

Hopkins, X, Gill, WA, Kringel, R, Wang, G, Hass, J, Acharya, S, Park, J, Jeon, IT, An, BH, Lee, JS, Ryu, JE, Hill, R, McIlroy, D, Kim, Y & Choi, DS 2017, 'Radio frequency-mediated local thermotherapy for destruction of pancreatic tumors using Ni-Au core-shell nanowires', Nanotechnology, vol. 28, no. 3, 03LT01. https://doi.org/10.1088/1361-6528/28/3/03LT01
Hopkins, Xiaoping ; Gill, Waqas Amin ; Kringel, Rosemarie ; Wang, Guankui ; Hass, Jamie ; Acharya, Suresh ; Park, Jungrae ; Jeon, In Tak ; An, Boo Hyun ; Lee, Ji Sung ; Ryu, Jong Eun ; Hill, Rod ; McIlroy, David ; Kim, Young-geun ; Choi, Daniel S. / Radio frequency-mediated local thermotherapy for destruction of pancreatic tumors using Ni-Au core-shell nanowires. In: Nanotechnology. 2017 ; Vol. 28, No. 3.
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