Abstract
Objectives: The purpose of this study was to compare the radiological findings before and after intratumoral bleomycin injection in patients with cystic craniopharyngioma so as to define the role of adjuvant intracavitary bleomycin chemotherapy for cystic craniopharyngiomas. Patients and methods: Eleven patients whose craniopharyngioma was confirmed cytologically and/or histologically were retrospectively reviewed. The follow-up duration ranged from 9 to 79 months (mean, 31.6 months). Only the solid portion of the cystic craniopharyngiomas was excised before repeated injections of bleomycin (15-180 mg in total) into the cystic portion through an Ommaya reservoir were given. The patients were evaluated neuroradiologically before and after bleomycin administration. Results: After the completion of all treatment cycles, the disappearance or shrinkage of the tumor was initially noted in all cases on follow-up CT and/or MR imaging studies. However, tumor recurrence was seen in four cases with a mixed tumor type. Conclusion: Postoperative bleomycin injection in cystic craniopharyngioma does not appear to totally eradicate the tumor and does not stop tumor recurrence unless the cyst is the only portion of the craniopharyngioma that is left. Nevertheless, postoperative bleomycin injection decreases and stabilizes tumor size, and thus may be considered as an option of treatment modalities in patients with predominantly cystic craniopharyngiomas.
| Original language | English |
|---|---|
| Pages (from-to) | 236-241 |
| Number of pages | 6 |
| Journal | Clinical Neurology and Neurosurgery |
| Volume | 109 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2007 Apr 1 |
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Keywords
- Bleomycin
- Craniopharyngioma
- Intratumoral injection
- Radiological findings
ASJC Scopus subject areas
- Surgery
- Clinical Neurology
Cite this
Radiological findings following postsurgical intratumoral bleomycin injection for cystic craniopharyngioma. / Kim, Sang-Dae; Park, Jung Yul; Park, Juno; Lee, Jang Bo; Kim, Se-Hoon; Lim, Dong Jun.
In: Clinical Neurology and Neurosurgery, Vol. 109, No. 3, 01.04.2007, p. 236-241.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Radiological findings following postsurgical intratumoral bleomycin injection for cystic craniopharyngioma
AU - Kim, Sang-Dae
AU - Park, Jung Yul
AU - Park, Juno
AU - Lee, Jang Bo
AU - Kim, Se-Hoon
AU - Lim, Dong Jun
PY - 2007/4/1
Y1 - 2007/4/1
N2 - Objectives: The purpose of this study was to compare the radiological findings before and after intratumoral bleomycin injection in patients with cystic craniopharyngioma so as to define the role of adjuvant intracavitary bleomycin chemotherapy for cystic craniopharyngiomas. Patients and methods: Eleven patients whose craniopharyngioma was confirmed cytologically and/or histologically were retrospectively reviewed. The follow-up duration ranged from 9 to 79 months (mean, 31.6 months). Only the solid portion of the cystic craniopharyngiomas was excised before repeated injections of bleomycin (15-180 mg in total) into the cystic portion through an Ommaya reservoir were given. The patients were evaluated neuroradiologically before and after bleomycin administration. Results: After the completion of all treatment cycles, the disappearance or shrinkage of the tumor was initially noted in all cases on follow-up CT and/or MR imaging studies. However, tumor recurrence was seen in four cases with a mixed tumor type. Conclusion: Postoperative bleomycin injection in cystic craniopharyngioma does not appear to totally eradicate the tumor and does not stop tumor recurrence unless the cyst is the only portion of the craniopharyngioma that is left. Nevertheless, postoperative bleomycin injection decreases and stabilizes tumor size, and thus may be considered as an option of treatment modalities in patients with predominantly cystic craniopharyngiomas.
AB - Objectives: The purpose of this study was to compare the radiological findings before and after intratumoral bleomycin injection in patients with cystic craniopharyngioma so as to define the role of adjuvant intracavitary bleomycin chemotherapy for cystic craniopharyngiomas. Patients and methods: Eleven patients whose craniopharyngioma was confirmed cytologically and/or histologically were retrospectively reviewed. The follow-up duration ranged from 9 to 79 months (mean, 31.6 months). Only the solid portion of the cystic craniopharyngiomas was excised before repeated injections of bleomycin (15-180 mg in total) into the cystic portion through an Ommaya reservoir were given. The patients were evaluated neuroradiologically before and after bleomycin administration. Results: After the completion of all treatment cycles, the disappearance or shrinkage of the tumor was initially noted in all cases on follow-up CT and/or MR imaging studies. However, tumor recurrence was seen in four cases with a mixed tumor type. Conclusion: Postoperative bleomycin injection in cystic craniopharyngioma does not appear to totally eradicate the tumor and does not stop tumor recurrence unless the cyst is the only portion of the craniopharyngioma that is left. Nevertheless, postoperative bleomycin injection decreases and stabilizes tumor size, and thus may be considered as an option of treatment modalities in patients with predominantly cystic craniopharyngiomas.
KW - Bleomycin
KW - Craniopharyngioma
KW - Intratumoral injection
KW - Radiological findings
UR - http://www.scopus.com/inward/record.url?scp=33847062089&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33847062089&partnerID=8YFLogxK
U2 - 10.1016/j.clineuro.2006.09.002
DO - 10.1016/j.clineuro.2006.09.002
M3 - Article
C2 - 17046151
AN - SCOPUS:33847062089
VL - 109
SP - 236
EP - 241
JO - Clinical Neurology and Neurosurgery
JF - Clinical Neurology and Neurosurgery
SN - 0303-8467
IS - 3
ER -