Radionuclide-embedded gold nanoparticles for enhanced dendritic cell-based cancer immunotherapy, sensitive and quantitative tracking of dendritic cells with PET and cerenkov luminescence

Sang Bong Lee, Su Bi Ahn, Sang Woo Lee, Shin Young Jeong, Yoon Ghilsuk, Byeong Cheol Ahn, Eun Mi Kim, Hwan Jeong Jeong, Jaetae Lee, Dong Kwon Lim, Yong Hyun Jeon

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)

Abstract

Radionuclide-embedded gold nanoparticles (RIe-AuNPs) were developed as a highly sensitive and stable nuclear and optical imaging agent for efficient dendritic cell (DC)-based immunotherapy and sensitive tracking of DC-migration to lymph nodes. The RIe-AuNPs were synthesized via simple and straightforward DNA-based radiolabeling chemistry and additional Au shell formation strategies, leading to high radiosensitivity and excellent in vivo stability. The RIe-AuNPs exert no adverse effects on the biological functions of DCs, and labeled DCs show strong antitumor immunity for lung cancer. Furthermore, the high radiosensitivity of the RIe-AuNPs allows for sensitive and long-term monitoring of DC migration to draining lymph nodes. The developed Cerenkov radiation-based optical imaging approach provides quantitative and sensitive results comparable with that of positron emission tomography imaging. These results highlight the strong potential of the RIe-AuNPs as a highly sensitive and stable nuclear and optical imaging platform for future bioimaging application such as cell tracking and tumor imaging.

Original languageEnglish
Article numbere281
Pages (from-to)1-10
Number of pages10
JournalNPG Asia Materials
Volume8
Issue number6
DOIs
Publication statusPublished - 2016

ASJC Scopus subject areas

  • Modelling and Simulation
  • Materials Science(all)
  • Condensed Matter Physics

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