Radiosurgery for brain metastasis from advanced gastric cancer

Jung Ho Han, Dong Gyu Kim, Hyun Tai Chung, Chae Yong Kim, Chul Kee Park, Young Seob Chung, Sun Ha Paek, Moon Won Yoo, Baek Hui Kim, Hee Won Jung

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13 Citations (Scopus)

Abstract

Purpose We retrospectively evaluated the survival of patients with brain metastases from advanced gastric cancer (AGC) after radiosurgery (RS). Methods Between 1998 and 2007, a total of 11 patients (median age, 61 years; range, 36-70) were diagnosed with brain metastasis from AGC and treated with RS. Each of five (46%) patients had two brain metastases. The median volume of the 16 lesions was 2.9 cm3 (range, 0.1-33.8). The median marginal dose prescribed was 20 Gy (range, 10-25) at the 50% isodose line. RS was the primary treatment for brain metastases in six patients. Results As of February 28, 2008, eight (73%) patients had died, and three (27%) were living with stable disease. The median survival time was 17.0±3.9 months (95% CI, 9.4-24.6). The median progression-free survival time was 9.0± 2.5 months (95% CI, 4.2-13.8). Patients who did not undergo WBRT died within 8 months, and the other six patients treated with WBRT at various time intervals from the diagnosis of brain metastases survived, with a median survival time of 19.0±3.4 months (95% CI, 12.4-25.6). Conclusions Radiosurgery seems to be a good alternative to surgical resection for patients with brain metastases from AGC, when performed in conjunction with WBRT.

Original languageEnglish
Pages (from-to)605-610
Number of pages6
JournalActa neurochirurgica
Volume152
Issue number4
DOIs
Publication statusPublished - 2010 Apr 1

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Keywords

  • Advanced gastric carcinoma
  • Brain metastasis
  • Gamma Knife radiosurgery
  • Whole-brain radiotherapy

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Han, J. H., Kim, D. G., Chung, H. T., Kim, C. Y., Park, C. K., Chung, Y. S., Paek, S. H., Yoo, M. W., Kim, B. H., & Jung, H. W. (2010). Radiosurgery for brain metastasis from advanced gastric cancer. Acta neurochirurgica, 152(4), 605-610. https://doi.org/10.1007/s00701-009-0554-4