Radiotherapy for 65 patients with advanced unresectable hepatocellular carcinoma

Yeon Seok Seo, Jin Nam Kim, Bora Keum, Sanghoon Park, Yong Dae Kwon, Yong Sik Kim, Yoon Tae Jeen, Hoon Jai Chun, Chul Yong Kim, Chang Duck Kim, Ho Sang Ryu, Soon Ho Um

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Abstract

Aim: To evaluate the efficacy of radiotherapy (RT) in patients with advanced unresectable hepatocellular carcinoma (HCC). Methods: A total of 65 patients were treated with RT in the Korea University Medical Center. The median age of the patients was 60 years, and 86.2% were men. 18.5% and 81.5% of the patients were diagnosed as TNM stage III and IV-A, respectively. Treatment response was assessed 4 mo after initiation of RT. Tumor regression rate 1 mo after initiation of RT (TRR1m) was also assessed. Duration of survival was calculated from the initiation of RT. Results: The objective treatment response was 56.9%. The 12 mo survival rate was 34.7%. Predictive factors for survival were Child-Pugh grade, α-fetoprotein level and treatment response. An objective response was achieved more frequently in patients with TRR1m ≥ 20% than in those with TRR1m < 20% (P < 0.001). Conclusion: RT is effective in treating advanced HCC with a tumor response rate of 56.9%.

Original languageEnglish
Pages (from-to)2394-2400
Number of pages7
JournalWorld journal of gastroenterology
Volume14
Issue number15
DOIs
Publication statusPublished - 2008 Apr 21

Keywords

  • Hepatocellular carcinoma
  • Radiotherapy
  • Survival
  • Treatment response

ASJC Scopus subject areas

  • Gastroenterology

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    Seo, Y. S., Kim, J. N., Keum, B., Park, S., Kwon, Y. D., Kim, Y. S., Jeen, Y. T., Chun, H. J., Kim, C. Y., Kim, C. D., Ryu, H. S., & Um, S. H. (2008). Radiotherapy for 65 patients with advanced unresectable hepatocellular carcinoma. World journal of gastroenterology, 14(15), 2394-2400. https://doi.org/10.3748/wjg.14.2394