Radiotherapy for 65 patients with advanced unresectable hepatocellular carcinoma

Yeon Seok Seo, Jin Nam Kim, Bora Keum, Sanghoon Park, Yong Dae Kwon, Yong Sik Kim, Yoon Tae Jeen, Hoon-Jai Chun, Chul Yong Kim, Chang Duck Kim, Ho Sang Ryu, Soon-Ho Um

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Abstract

Aim: To evaluate the efficacy of radiotherapy (RT) in patients with advanced unresectable hepatocellular carcinoma (HCC). Methods: A total of 65 patients were treated with RT in the Korea University Medical Center. The median age of the patients was 60 years, and 86.2% were men. 18.5% and 81.5% of the patients were diagnosed as TNM stage III and IV-A, respectively. Treatment response was assessed 4 mo after initiation of RT. Tumor regression rate 1 mo after initiation of RT (TRR1m) was also assessed. Duration of survival was calculated from the initiation of RT. Results: The objective treatment response was 56.9%. The 12 mo survival rate was 34.7%. Predictive factors for survival were Child-Pugh grade, α-fetoprotein level and treatment response. An objective response was achieved more frequently in patients with TRR1m ≥ 20% than in those with TRR1m < 20% (P < 0.001). Conclusion: RT is effective in treating advanced HCC with a tumor response rate of 56.9%.

Original languageEnglish
Pages (from-to)2394-2400
Number of pages7
JournalWorld Journal of Gastroenterology
Volume14
Issue number15
DOIs
Publication statusPublished - 2008 Apr 21

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Keywords

  • Hepatocellular carcinoma
  • Radiotherapy
  • Survival
  • Treatment response

ASJC Scopus subject areas

  • Gastroenterology

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