RanBPM protein acts as a negative regulator of BLT2 receptor to attenuate BLT2-mediated cell motility

Jun Dong Wei, Joo Young Kim, Ae Kyoung Kim, Sung Key Jang, Jae-Hong Kim

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: The regulatory mechanism of BLT2 is largely unknown. Results: RanBPM interacts with BLT2 and inhibits BLT2-induced ROS generation and chemotaxis. Conclusion: Our findings suggest that RanBPM acts as a negative regulator of BLT2. Significance: Identification of regulators would provide better understanding of BLT2 signaling and potentially various BLT2- associated inflammatory pathogenesis.

Original languageEnglish
Pages (from-to)26753-26763
Number of pages11
JournalJournal of Biological Chemistry
Volume288
Issue number37
DOIs
Publication statusPublished - 2013 Sep 13

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ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

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