RanBPM protein acts as a negative regulator of BLT2 receptor to attenuate BLT2-mediated cell motility

Jun Dong Wei, Joo Young Kim, Ae Kyoung Kim, Sung Key Jang, Jae-Hong Kim

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: The regulatory mechanism of BLT2 is largely unknown. Results: RanBPM interacts with BLT2 and inhibits BLT2-induced ROS generation and chemotaxis. Conclusion: Our findings suggest that RanBPM acts as a negative regulator of BLT2. Significance: Identification of regulators would provide better understanding of BLT2 signaling and potentially various BLT2- associated inflammatory pathogenesis.

Original languageEnglish
Pages (from-to)26753-26763
Number of pages11
JournalJournal of Biological Chemistry
Volume288
Issue number37
DOIs
Publication statusPublished - 2013 Sep 13

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Cell Movement
Chemotaxis
Proteins
Ran binding protein 9

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

RanBPM protein acts as a negative regulator of BLT2 receptor to attenuate BLT2-mediated cell motility. / Wei, Jun Dong; Kim, Joo Young; Kim, Ae Kyoung; Jang, Sung Key; Kim, Jae-Hong.

In: Journal of Biological Chemistry, Vol. 288, No. 37, 13.09.2013, p. 26753-26763.

Research output: Contribution to journalArticle

Wei, Jun Dong ; Kim, Joo Young ; Kim, Ae Kyoung ; Jang, Sung Key ; Kim, Jae-Hong. / RanBPM protein acts as a negative regulator of BLT2 receptor to attenuate BLT2-mediated cell motility. In: Journal of Biological Chemistry. 2013 ; Vol. 288, No. 37. pp. 26753-26763.
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