Randomized clinical trial on the efficacy of Escherichia coliderived rhBMP-2 with ß-TCP/HA in extraction socket

Jung Bo Huh, Hyo Jung Lee, Ji Woong Jang, Myung Jin Kim, Pil Young Yun, Su Hong Kim, Kyung Hee Choi, Young Kyun Kim, Kyoo Sung Cho, Sang-Wan Shin

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Purpose: This randomized clinical trial was conducted to assess the safety and effectiveness of the ErhBMP-2 in alveolar bone regeneration as well as preservation of the ß-TCP bone graft material that contains ErhBMP-2. Materials and Methods: This study involved 72 patients at the 3 study centers. The patients, who were divided into 2 groups: the experiment group who had ErhBMP-2 coated TCP/HA and the control group who had TCP/HA graft material alone transplanted immediately after tooth extraction. CT was taken before and 3 months after the transplantation and healing status was compared between the two groups. The efficacy endpoints that were used to measure the degree of bone induction included alveolar bone height and 3 measurements of bone width. The paired t test was used to determine the significance of the changes (P<.05). Results: Changes in alveolar bone height were -1.087± 1.413 mm in the control group and -.059± 0.960 mm in the experimental group (P<.01). At 25% extraction socket length [ESL], the changes were 0.006 ± 1.149 mm in the control group and 1.279 ± 1.387 mm in the experimental group. At 50% ESL, the changes were 0.542± 1.157 mm and 1.239± 1.249 mm, respectively (P<.01 for 25% ESL, and P<.05 for 50% ESL). During the experiment, no adverse reactions to the graft material were observed. Conclusion: ErhBMP-2 coated ß-TCP/HA were found to be more effective in preserving alveolar bone than conventional ß-TCP/HA alloplastic bone graft materials.

Original languageEnglish
Pages (from-to)161-165
Number of pages5
JournalJournal of Advanced Prosthodontics
Volume3
Issue number3
DOIs
Publication statusPublished - 2011 Dec 1

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Escherichia
Randomized Controlled Trials
Bone and Bones
Transplants
Control Groups
Tooth Extraction
Bone Regeneration
Transplantation
Safety

Keywords

  • ß-TCP/HA
  • Alveolar bone regeneration
  • ErhBMP-2
  • Randomized clinical trial
  • Tooth extraction

ASJC Scopus subject areas

  • Dentistry (miscellaneous)
  • Oral Surgery

Cite this

Randomized clinical trial on the efficacy of Escherichia coliderived rhBMP-2 with ß-TCP/HA in extraction socket. / Huh, Jung Bo; Lee, Hyo Jung; Jang, Ji Woong; Kim, Myung Jin; Yun, Pil Young; Kim, Su Hong; Choi, Kyung Hee; Kim, Young Kyun; Cho, Kyoo Sung; Shin, Sang-Wan.

In: Journal of Advanced Prosthodontics, Vol. 3, No. 3, 01.12.2011, p. 161-165.

Research output: Contribution to journalArticle

Huh, Jung Bo ; Lee, Hyo Jung ; Jang, Ji Woong ; Kim, Myung Jin ; Yun, Pil Young ; Kim, Su Hong ; Choi, Kyung Hee ; Kim, Young Kyun ; Cho, Kyoo Sung ; Shin, Sang-Wan. / Randomized clinical trial on the efficacy of Escherichia coliderived rhBMP-2 with ß-TCP/HA in extraction socket. In: Journal of Advanced Prosthodontics. 2011 ; Vol. 3, No. 3. pp. 161-165.
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AU - Kim, Myung Jin

AU - Yun, Pil Young

AU - Kim, Su Hong

AU - Choi, Kyung Hee

AU - Kim, Young Kyun

AU - Cho, Kyoo Sung

AU - Shin, Sang-Wan

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AB - Purpose: This randomized clinical trial was conducted to assess the safety and effectiveness of the ErhBMP-2 in alveolar bone regeneration as well as preservation of the ß-TCP bone graft material that contains ErhBMP-2. Materials and Methods: This study involved 72 patients at the 3 study centers. The patients, who were divided into 2 groups: the experiment group who had ErhBMP-2 coated TCP/HA and the control group who had TCP/HA graft material alone transplanted immediately after tooth extraction. CT was taken before and 3 months after the transplantation and healing status was compared between the two groups. The efficacy endpoints that were used to measure the degree of bone induction included alveolar bone height and 3 measurements of bone width. The paired t test was used to determine the significance of the changes (P<.05). Results: Changes in alveolar bone height were -1.087± 1.413 mm in the control group and -.059± 0.960 mm in the experimental group (P<.01). At 25% extraction socket length [ESL], the changes were 0.006 ± 1.149 mm in the control group and 1.279 ± 1.387 mm in the experimental group. At 50% ESL, the changes were 0.542± 1.157 mm and 1.239± 1.249 mm, respectively (P<.01 for 25% ESL, and P<.05 for 50% ESL). During the experiment, no adverse reactions to the graft material were observed. Conclusion: ErhBMP-2 coated ß-TCP/HA were found to be more effective in preserving alveolar bone than conventional ß-TCP/HA alloplastic bone graft materials.

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KW - Tooth extraction

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