Abstract
Purpose: This randomized clinical trial was conducted to assess the safety and effectiveness of the ErhBMP-2 in alveolar bone regeneration as well as preservation of the ß-TCP bone graft material that contains ErhBMP-2. Materials and Methods: This study involved 72 patients at the 3 study centers. The patients, who were divided into 2 groups: the experiment group who had ErhBMP-2 coated TCP/HA and the control group who had TCP/HA graft material alone transplanted immediately after tooth extraction. CT was taken before and 3 months after the transplantation and healing status was compared between the two groups. The efficacy endpoints that were used to measure the degree of bone induction included alveolar bone height and 3 measurements of bone width. The paired t test was used to determine the significance of the changes (P<.05). Results: Changes in alveolar bone height were -1.087± 1.413 mm in the control group and -.059± 0.960 mm in the experimental group (P<.01). At 25% extraction socket length [ESL], the changes were 0.006 ± 1.149 mm in the control group and 1.279 ± 1.387 mm in the experimental group. At 50% ESL, the changes were 0.542± 1.157 mm and 1.239± 1.249 mm, respectively (P<.01 for 25% ESL, and P<.05 for 50% ESL). During the experiment, no adverse reactions to the graft material were observed. Conclusion: ErhBMP-2 coated ß-TCP/HA were found to be more effective in preserving alveolar bone than conventional ß-TCP/HA alloplastic bone graft materials.
| Original language | English |
|---|---|
| Pages (from-to) | 161-165 |
| Number of pages | 5 |
| Journal | Journal of Advanced Prosthodontics |
| Volume | 3 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2011 Dec 1 |
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Keywords
- ß-TCP/HA
- Alveolar bone regeneration
- ErhBMP-2
- Randomized clinical trial
- Tooth extraction
ASJC Scopus subject areas
- Dentistry (miscellaneous)
- Oral Surgery
Cite this
Randomized clinical trial on the efficacy of Escherichia coliderived rhBMP-2 with ß-TCP/HA in extraction socket. / Huh, Jung Bo; Lee, Hyo Jung; Jang, Ji Woong; Kim, Myung Jin; Yun, Pil Young; Kim, Su Hong; Choi, Kyung Hee; Kim, Young Kyun; Cho, Kyoo Sung; Shin, Sang-Wan.
In: Journal of Advanced Prosthodontics, Vol. 3, No. 3, 01.12.2011, p. 161-165.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Randomized clinical trial on the efficacy of Escherichia coliderived rhBMP-2 with ß-TCP/HA in extraction socket
AU - Huh, Jung Bo
AU - Lee, Hyo Jung
AU - Jang, Ji Woong
AU - Kim, Myung Jin
AU - Yun, Pil Young
AU - Kim, Su Hong
AU - Choi, Kyung Hee
AU - Kim, Young Kyun
AU - Cho, Kyoo Sung
AU - Shin, Sang-Wan
PY - 2011/12/1
Y1 - 2011/12/1
N2 - Purpose: This randomized clinical trial was conducted to assess the safety and effectiveness of the ErhBMP-2 in alveolar bone regeneration as well as preservation of the ß-TCP bone graft material that contains ErhBMP-2. Materials and Methods: This study involved 72 patients at the 3 study centers. The patients, who were divided into 2 groups: the experiment group who had ErhBMP-2 coated TCP/HA and the control group who had TCP/HA graft material alone transplanted immediately after tooth extraction. CT was taken before and 3 months after the transplantation and healing status was compared between the two groups. The efficacy endpoints that were used to measure the degree of bone induction included alveolar bone height and 3 measurements of bone width. The paired t test was used to determine the significance of the changes (P<.05). Results: Changes in alveolar bone height were -1.087± 1.413 mm in the control group and -.059± 0.960 mm in the experimental group (P<.01). At 25% extraction socket length [ESL], the changes were 0.006 ± 1.149 mm in the control group and 1.279 ± 1.387 mm in the experimental group. At 50% ESL, the changes were 0.542± 1.157 mm and 1.239± 1.249 mm, respectively (P<.01 for 25% ESL, and P<.05 for 50% ESL). During the experiment, no adverse reactions to the graft material were observed. Conclusion: ErhBMP-2 coated ß-TCP/HA were found to be more effective in preserving alveolar bone than conventional ß-TCP/HA alloplastic bone graft materials.
AB - Purpose: This randomized clinical trial was conducted to assess the safety and effectiveness of the ErhBMP-2 in alveolar bone regeneration as well as preservation of the ß-TCP bone graft material that contains ErhBMP-2. Materials and Methods: This study involved 72 patients at the 3 study centers. The patients, who were divided into 2 groups: the experiment group who had ErhBMP-2 coated TCP/HA and the control group who had TCP/HA graft material alone transplanted immediately after tooth extraction. CT was taken before and 3 months after the transplantation and healing status was compared between the two groups. The efficacy endpoints that were used to measure the degree of bone induction included alveolar bone height and 3 measurements of bone width. The paired t test was used to determine the significance of the changes (P<.05). Results: Changes in alveolar bone height were -1.087± 1.413 mm in the control group and -.059± 0.960 mm in the experimental group (P<.01). At 25% extraction socket length [ESL], the changes were 0.006 ± 1.149 mm in the control group and 1.279 ± 1.387 mm in the experimental group. At 50% ESL, the changes were 0.542± 1.157 mm and 1.239± 1.249 mm, respectively (P<.01 for 25% ESL, and P<.05 for 50% ESL). During the experiment, no adverse reactions to the graft material were observed. Conclusion: ErhBMP-2 coated ß-TCP/HA were found to be more effective in preserving alveolar bone than conventional ß-TCP/HA alloplastic bone graft materials.
KW - ß-TCP/HA
KW - Alveolar bone regeneration
KW - ErhBMP-2
KW - Randomized clinical trial
KW - Tooth extraction
UR - http://www.scopus.com/inward/record.url?scp=84882686292&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84882686292&partnerID=8YFLogxK
U2 - 10.4047/jap.2011.3.3.161
DO - 10.4047/jap.2011.3.3.161
M3 - Article
C2 - 22053248
AN - SCOPUS:84882686292
VL - 3
SP - 161
EP - 165
JO - Journal of Advanced Prosthodontics
JF - Journal of Advanced Prosthodontics
SN - 2005-7806
IS - 3
ER -