RANTES polymorphisms and the risk of graft-versus-host disease in human leukocyte antigen-matched sibling allogeneic hematopoietic stem cell transplantation

Dong Yeop Shin, Inho Kim, Jin Hee Kim, Yun Gyoo Lee, Eun Joo Kang, Hyeon Jin Cho, Kyung Hun Lee, Hye Jin Kim, Eun Hee Park, Jong Eun Lee, Ji Yeon Bae, Cha Ja See, Sung Soo Yoon, Sung Sup Park, Kyou Sup Han, Myoung Hee Park, Yun Chul Hong, Seonyang Park, Byoung Kook Kim

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We investigated the association between RANTES (regulated upon activation, normal T cell expressed and secreted) polymorphisms and clinical outcomes in patients treated with allogeneic hematopoietic stem cell transplantation (allo-HSCT). Three RANTES gene polymorphisms, i.e. -403G/A (rs2107538), -28C/G (rs2280788) and In1.1T/C (rs2280789), were genotyped, and the effects of the genotypes and haplotypes of RANTES on clinical outcomes were analyzed. The competing risk regression analysis was used to investigate the relationship between the polymorphisms and the cumulative risk of graft-versus-host disease (GVHD). An AGC haplotype in a recessive model showed significant harmful effects on the cumulative risk of acute GVHD and relapse-free survival (adjusted hazard ratios 2.42 and 2.71, 95% confidence intervals 1.29-4.55 and 1.30-5.64; p = 0.018 and 0.024, respectively), whereas a GCT haplotype did not. RANTES polymorphisms were not significantly associated with overall survival and the risk of chronic GVHD. This study suggests that RANTES polymorphisms might be associated with the occurrence of acute GVHD rather than of chronic GVHD and also of relapse-free survival in the patients treated with allo-HSCT. Further larger prospective investigations are needed to establish the role of RANTES polymorphisms in patients treated with allo-HSCT.

Original languageEnglish
Pages (from-to)137-145
Number of pages9
JournalActa Haematologica
Volume129
Issue number3
DOIs
Publication statusPublished - 2013 Jan 1
Externally publishedYes

    Fingerprint

Keywords

  • Bone marrow transplantation
  • Graft-versus-host disease
  • Hematopoietic stem cell transplantation
  • Polymorphism
  • RANTES

ASJC Scopus subject areas

  • Hematology

Cite this

Shin, D. Y., Kim, I., Kim, J. H., Lee, Y. G., Kang, E. J., Cho, H. J., Lee, K. H., Kim, H. J., Park, E. H., Lee, J. E., Bae, J. Y., See, C. J., Yoon, S. S., Park, S. S., Han, K. S., Park, M. H., Hong, Y. C., Park, S., & Kim, B. K. (2013). RANTES polymorphisms and the risk of graft-versus-host disease in human leukocyte antigen-matched sibling allogeneic hematopoietic stem cell transplantation. Acta Haematologica, 129(3), 137-145. https://doi.org/10.1159/000343273