Rapidly dissolving fibroin microneedles for transdermal drug delivery

Xueqiu You, Jong Hyeon Chang, Byeong Kwon Ju, James Jungho Pak

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

This paper presents rapidly dissolving fibroin microneedles (MNs) for the first time. A reverse PDMS MNs mold was first created and drug-contained fibroin solution was poured into this reverse PDMS MNs mold. Fibroin MNs were successfully fabricated after fan drying and detaching the solidified drug-contained fibroin structure from the PDMS mold. The fibroin serves as a matrix to incorporate drug molecules while maintaining the drug activity. The dimensions of the fabricated fibroin MNs are 500 μm in length, 200 μm in diameter at the base, and 5 μm in radius at the tip. These fibroin MNs can dissolve within minutes under the skin to release the drug molecules and the dissolved fibroin in the skin generates noninflammatory amino acid degradation products usable in cell metabolic functions. The fibroin MNs containing methylene blue as a drug were fabricated and their surface morphology, internal structure, mechanical property, and the dissolving characteristics were analyzed. These rapidly dissolving fibroin MNs provide more benefit than conventional syringes for painless transdermal drug delivery.

Original languageEnglish
Pages (from-to)1632-1636
Number of pages5
JournalMaterials Science and Engineering C
Volume31
Issue number8
DOIs
Publication statusPublished - 2011 Dec 1

Fingerprint

Fibroins
Drug delivery
delivery
Skin
dissolving
drugs
Syringes
Molecules
Fans
Surface morphology
Amino acids
Drying
Degradation
Mechanical properties
Pharmaceutical Preparations
syringes
methylene blue
fans
drying
amino acids

Keywords

  • Bio-degradable micro-needle
  • Silk fibroin
  • Transdermal drug delivery

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering
  • Mechanics of Materials

Cite this

Rapidly dissolving fibroin microneedles for transdermal drug delivery. / You, Xueqiu; Chang, Jong Hyeon; Ju, Byeong Kwon; Pak, James Jungho.

In: Materials Science and Engineering C, Vol. 31, No. 8, 01.12.2011, p. 1632-1636.

Research output: Contribution to journalArticle

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