Rapidly dissolving silk protein microneedles for transdermal drug delivery

Xueqiu You, James Jungho Pak, Jong Hyeon Chang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

This paper presents rapidly dissolving fibroin microneedles for the first time. A reverse PDMS microneedles mold was first created and drug-contained fibroin solution was poured into this reverse PDMS microneedles mold. Fibroin microneedles were successfully fabricated after drying and detaching the solidified fibroin structure from the PDMS mold. These fibroin microneedles serve as a matrix to incorporate drug molecules while maintaining the drug activity. The dimensions of the fabricated fibroin microneedles are 500 μm in length, 200 μm in diameter at the base, and 5 μm in radius at the tip. These fibroin matrix microneedles can dissolve within one minute under the skin to release the drug molecules and the dissolved fibroin in the skin generates noninflammatory amino acid degradation products usable in cell metabolic functions. The fibroin microneedles containing methylene blue as a drug were fabricated and their surface morphology, internal layered structure, mechanical property, and the dissolving characteristics were examined. These rapidly dissolving fibroin microneedles provide more benefit than conventional syringes for painless transdermal drug delivery.

Original languageEnglish
Title of host publication2010 IEEE International Conference on Nano/Molecular Medicine and Engineering, IEEE NANOMED 2010
Pages144-147
Number of pages4
DOIs
Publication statusPublished - 2010
Event4th IEEE International Conference on Nano/Molecular Medicine and Engineering, IEEE NANOMED 2010 - Hong Kong/Macau, China
Duration: 2010 Dec 52010 Dec 9

Publication series

Name2010 IEEE International Conference on Nano/Molecular Medicine and Engineering, IEEE NANOMED 2010

Other

Other4th IEEE International Conference on Nano/Molecular Medicine and Engineering, IEEE NANOMED 2010
CountryChina
CityHong Kong/Macau
Period10/12/510/12/9

Keywords

  • Transdermal drug delivery
  • bio-degradable microneedle
  • silk fibroin

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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  • Cite this

    You, X., Pak, J. J., & Chang, J. H. (2010). Rapidly dissolving silk protein microneedles for transdermal drug delivery. In 2010 IEEE International Conference on Nano/Molecular Medicine and Engineering, IEEE NANOMED 2010 (pp. 144-147). [5749822] (2010 IEEE International Conference on Nano/Molecular Medicine and Engineering, IEEE NANOMED 2010). https://doi.org/10.1109/NANOMED.2010.5749822