Rational design of a multifunctional molecular dye for dual-modal NIR-II/photoacoustic imaging and photothermal therapy

Ruiping Zhang, Yuling Xu, Yi Zhang, Hyeong Seok Kim, Amit Sharma, Jing Gao, Guangfu Yang, Jong Seung Kim, Yao Sun

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Small-molecule based multifunctional probes play significant roles in biomedical science and possess high clinical translational ability. However, the preparation of these promising probes without complicated synthetic procedures remains a challenging task. Herein, we rationally designed a high-performance DD-A-DD scaffold molecular dye (SYL) with an intrinsic multifunctional ability and then incorporated it into DSPE-mPEG5000 to facilely construct biocompatible NIR-II fluorescent and photoacoustic (PA) dual-modal theranostic nanoprobes (SYL NPs) (∼120 nm). In vivo studies confirmed that SYL NPs exhibited bright NIR-II fluorescence and PA signals in the tumor region with a promising signal to background ratio (S/B). Meanwhile, SYL NPs demonstrated significantly inhibited tumor growth under laser irradiation with no noticeable side effects. These promising results highlighted SYL NPs as a potential theranostic platform for cancer diagnosis (NIR-II region) and therapy.

Original languageEnglish
Pages (from-to)8348-8353
Number of pages6
JournalChemical Science
Volume10
Issue number36
DOIs
Publication statusPublished - 2019 Jan 1

Fingerprint

Photoacoustic effect
Tumors
Coloring Agents
Nanoprobes
Imaging techniques
Laser beam effects
Scaffolds
Fluorescence
Molecules
1,2-distearoylphosphatidylethanolamine

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Rational design of a multifunctional molecular dye for dual-modal NIR-II/photoacoustic imaging and photothermal therapy. / Zhang, Ruiping; Xu, Yuling; Zhang, Yi; Kim, Hyeong Seok; Sharma, Amit; Gao, Jing; Yang, Guangfu; Kim, Jong Seung; Sun, Yao.

In: Chemical Science, Vol. 10, No. 36, 01.01.2019, p. 8348-8353.

Research output: Contribution to journalArticle

Zhang, Ruiping ; Xu, Yuling ; Zhang, Yi ; Kim, Hyeong Seok ; Sharma, Amit ; Gao, Jing ; Yang, Guangfu ; Kim, Jong Seung ; Sun, Yao. / Rational design of a multifunctional molecular dye for dual-modal NIR-II/photoacoustic imaging and photothermal therapy. In: Chemical Science. 2019 ; Vol. 10, No. 36. pp. 8348-8353.
@article{2560aaf354e247e2938176018b8845c8,
title = "Rational design of a multifunctional molecular dye for dual-modal NIR-II/photoacoustic imaging and photothermal therapy",
abstract = "Small-molecule based multifunctional probes play significant roles in biomedical science and possess high clinical translational ability. However, the preparation of these promising probes without complicated synthetic procedures remains a challenging task. Herein, we rationally designed a high-performance DD-A-DD scaffold molecular dye (SYL) with an intrinsic multifunctional ability and then incorporated it into DSPE-mPEG5000 to facilely construct biocompatible NIR-II fluorescent and photoacoustic (PA) dual-modal theranostic nanoprobes (SYL NPs) (∼120 nm). In vivo studies confirmed that SYL NPs exhibited bright NIR-II fluorescence and PA signals in the tumor region with a promising signal to background ratio (S/B). Meanwhile, SYL NPs demonstrated significantly inhibited tumor growth under laser irradiation with no noticeable side effects. These promising results highlighted SYL NPs as a potential theranostic platform for cancer diagnosis (NIR-II region) and therapy.",
author = "Ruiping Zhang and Yuling Xu and Yi Zhang and Kim, {Hyeong Seok} and Amit Sharma and Jing Gao and Guangfu Yang and Kim, {Jong Seung} and Yao Sun",
year = "2019",
month = "1",
day = "1",
doi = "10.1039/c9sc03504d",
language = "English",
volume = "10",
pages = "8348--8353",
journal = "Chemical Science",
issn = "2041-6520",
publisher = "Royal Society of Chemistry",
number = "36",

}

TY - JOUR

T1 - Rational design of a multifunctional molecular dye for dual-modal NIR-II/photoacoustic imaging and photothermal therapy

AU - Zhang, Ruiping

AU - Xu, Yuling

AU - Zhang, Yi

AU - Kim, Hyeong Seok

AU - Sharma, Amit

AU - Gao, Jing

AU - Yang, Guangfu

AU - Kim, Jong Seung

AU - Sun, Yao

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Small-molecule based multifunctional probes play significant roles in biomedical science and possess high clinical translational ability. However, the preparation of these promising probes without complicated synthetic procedures remains a challenging task. Herein, we rationally designed a high-performance DD-A-DD scaffold molecular dye (SYL) with an intrinsic multifunctional ability and then incorporated it into DSPE-mPEG5000 to facilely construct biocompatible NIR-II fluorescent and photoacoustic (PA) dual-modal theranostic nanoprobes (SYL NPs) (∼120 nm). In vivo studies confirmed that SYL NPs exhibited bright NIR-II fluorescence and PA signals in the tumor region with a promising signal to background ratio (S/B). Meanwhile, SYL NPs demonstrated significantly inhibited tumor growth under laser irradiation with no noticeable side effects. These promising results highlighted SYL NPs as a potential theranostic platform for cancer diagnosis (NIR-II region) and therapy.

AB - Small-molecule based multifunctional probes play significant roles in biomedical science and possess high clinical translational ability. However, the preparation of these promising probes without complicated synthetic procedures remains a challenging task. Herein, we rationally designed a high-performance DD-A-DD scaffold molecular dye (SYL) with an intrinsic multifunctional ability and then incorporated it into DSPE-mPEG5000 to facilely construct biocompatible NIR-II fluorescent and photoacoustic (PA) dual-modal theranostic nanoprobes (SYL NPs) (∼120 nm). In vivo studies confirmed that SYL NPs exhibited bright NIR-II fluorescence and PA signals in the tumor region with a promising signal to background ratio (S/B). Meanwhile, SYL NPs demonstrated significantly inhibited tumor growth under laser irradiation with no noticeable side effects. These promising results highlighted SYL NPs as a potential theranostic platform for cancer diagnosis (NIR-II region) and therapy.

UR - http://www.scopus.com/inward/record.url?scp=85072596845&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85072596845&partnerID=8YFLogxK

U2 - 10.1039/c9sc03504d

DO - 10.1039/c9sc03504d

M3 - Article

AN - SCOPUS:85072596845

VL - 10

SP - 8348

EP - 8353

JO - Chemical Science

JF - Chemical Science

SN - 2041-6520

IS - 36

ER -