@article{2560aaf354e247e2938176018b8845c8,
title = "Rational design of a multifunctional molecular dye for dual-modal NIR-II/photoacoustic imaging and photothermal therapy",
abstract = "Small-molecule based multifunctional probes play significant roles in biomedical science and possess high clinical translational ability. However, the preparation of these promising probes without complicated synthetic procedures remains a challenging task. Herein, we rationally designed a high-performance DD-A-DD scaffold molecular dye (SYL) with an intrinsic multifunctional ability and then incorporated it into DSPE-mPEG5000 to facilely construct biocompatible NIR-II fluorescent and photoacoustic (PA) dual-modal theranostic nanoprobes (SYL NPs) (∼120 nm). In vivo studies confirmed that SYL NPs exhibited bright NIR-II fluorescence and PA signals in the tumor region with a promising signal to background ratio (S/B). Meanwhile, SYL NPs demonstrated significantly inhibited tumor growth under laser irradiation with no noticeable side effects. These promising results highlighted SYL NPs as a potential theranostic platform for cancer diagnosis (NIR-II region) and therapy.",
author = "Ruiping Zhang and Yuling Xu and Yi Zhang and Kim, {Hyeong Seok} and Amit Sharma and Jing Gao and Guangfu Yang and Kim, {Jong Seung} and Yao Sun",
note = "Funding Information: This work was partially supported by grants from the National Key R&D Programgs1: (2017YFA0505203), NSFC (21708012), 111 project B17019, and NSFHP (2017CFB151) and nancially supported by self-determined research funds of CCNU from the colleges (1100-30106190234), basic research and operation of MOE, Wuhan Morning Light Plan of Youth Science and Technology (201705304010321), Wuhan scientic and technological projects (2019020701011441), the Open Research Fund of Jiangsu Key Laboratory of Medical Optics (JKLMO201803) from Jiangsu Key Laboratory of Medical Optics, Suzhou Institute of Biomedical Engineering and Technology, and the Chinese Academy of Sciences, Suzhou 215163 (P. R. China). We are also thankful to research grants numbered 2018R1A3B1052702 and NRF-2019M3E5D1A01068998 (J. S. K.). Thanks to Suzhou NIR-Optics Technologies Co., Ltd (Suzhou, China). Without their technical help, this project could not have proceeded smoothly. Funding Information: This work was partially supported by grants from the National Key R&D Programgs1: (2017YFA0505203), NSFC (21708012), 111 project B17019, and NSFHP (2017CFB151) and financially supported by self-determined research funds of CCNU from the colleges (1100-30106190234), basic research and operation of MOE, Wuhan Morning Light Plan of Youth Science and Technology (201705304010321), Wuhan scientific and technological projects (2019020701011441), the Open Research Fund of Jiangsu Key Laboratory of Medical Optics (JKLMO201803) from Jiangsu Key Laboratory of Medical Optics, Suzhou Institute of Biomedical Engineering and Technology, and the Chinese Academy of Sciences, Suzhou 215163 (P. R. China). We are also thankful to research grants numbered 2018R1A3B1052702 and NRF-2019M3E5D1A01068998 (J. S. K.). Thanks to Suzhou NIR-Optics Technologies Co., Ltd (Suzhou, China). Without their technical help, this project could not have proceeded smoothly. Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2019.",
year = "2019",
doi = "10.1039/c9sc03504d",
language = "English",
volume = "10",
pages = "8348--8353",
journal = "Chemical Science",
issn = "2041-6520",
publisher = "Royal Society of Chemistry",
number = "36",
}
