Rational design of biotin-disulfide-coumarin conjugates: a cancer targeted thiol probe and bioimaging

Danbi Jung, Sukhendu Maiti, Jae Hong Lee, Joung Hae Lee, Jong Seung Kim

Research output: Contribution to journalArticlepeer-review

64 Citations (Scopus)

Abstract

Biotin-disulfide-coumarin conjugates are designed and synthesized as novel fluorescent sensors for cancer targeted intracellular thiol imaging in living organisms. In vitro experiments disclose that probe 6 is preferentially taken up by biotin receptor-positive A549 tumor cells through receptor mediated endocytosis.

Original languageEnglish
Pages (from-to)3044-3047
Number of pages4
JournalChemical Communications
Volume50
Issue number23
DOIs
Publication statusPublished - 2014 Feb 20

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Fingerprint Dive into the research topics of 'Rational design of biotin-disulfide-coumarin conjugates: a cancer targeted thiol probe and bioimaging'. Together they form a unique fingerprint.

Cite this