Rationale, design, and endpoints of the ‘DEvice-Detected CArdiac Tachyarrhythmic Events and Sleep-disordered Breathing (DEDiCATES)’ study: Prospective multicenter observational study of device-detected tachyarrhythmia and sleep-disordered breathing

Hye Bin Gwag, Youngjun Park, Seong Soo Lee, June Soo Kim, Kyoung Min Park, Young Keun On, Dae In Lee, Dong Gu Shin, Eue Keun Choi, Gu Hyun Kang, Hyoung Seob Park, Hyung Wook Park, Jae Min Shim, Jae Sun Uhm, Jun Kim, Jun Hyung Kim, Ki Woon Kang, Sang Weon Park, Yong Seog Oh, Youngjin ChoYoung Soo Lee, Seung Jung Park

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Background: Few studies have investigated the prognostic value of cardiac implantable electronic device (CIED)-detection of sleep-disordered breathing (SDB) for risk stratification of cardiovascular events. In the Device-Detected CArdiac Tachyarrhythmic events and Sleep-disordered breathing (DEDiCATES) study, we aim to determine whether device-detected SDB events are associated with increased risk of cardiac arrhythmias or other cardiovascular outcomes. Methods and design: Six-hundred patients (300 patients with low-voltage pacing devices and 300 with high-voltage defibrillator devices) who have dual chamber CIEDs with AP Scan™ function (Boston Scientific Inc., Marlborough, MA, USA) are planned to be enrolled in this study. AP Scan reports the average number of sleep disturbance events per hour per night in the form of a Respiratory Disturbance Index (RDI). The daily RDI values are to be used for quantitative measurement of the severity and burden of SDB. CIED-detected atrial high rate episodes (AHREs) and clinical atrial tachyarrhythmia will be assessed as the primary outcomes over a follow-up period of 2 years. Correlations between CIED-detected SDB and AHRE burdens will be analyzed. The secondary outcomes are CIED-detected or clinical ventricular arrhythmic events, stroke, heart failure hospitalization, mortality, and quality of life. Conclusion: This study will determine the prognostic value of automated diagnostic function of CIED for SDB, which will help to improve the cardiovascular prognoses of CIED patients by enabling convenient and accurate assessments of SDB events.

Original languageEnglish
Pages (from-to)69-73
Number of pages5
JournalInternational Journal of Cardiology
Volume280
DOIs
Publication statusPublished - 2019 Apr 1

Keywords

  • Arrhythmia
  • Cardiac implantable electronic device
  • Obstructive sleep apnea
  • Sleep-disordered breathing

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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