Rationally designed fluorescence ‘turn-on’ sensor for Cu2+

Kyoung Chul Ko; Jia Sheng Wu; Hyun Jung Kim; Pil Seung Kwon; Jong Wan Kim; Richard A. Bartsch; Jin Yong Lee; Jong Seung Kim

doi:10.1039/c0cc05421f

Rationally designed fluorescence ‘turn-on’ sensor for Cu²⁺

Kyoung Chul Ko, Jia Sheng Wu, Hyun Jung Kim, Pil Seung Kwon, Jong Wan Kim, Richard A. Bartsch, Jin Yong Lee, Jong Seung Kim

Research output: Contribution to journal › Article › peer-review

160 Citations (Scopus)

Abstract

A rationally designed, coumarin-based fluorescent sensor imino-coumarin (IC) displays high selectivity for Cu²⁺ over a variety of competing metal ions in aqueous solution with a significant fluorescence increase. DFT/TDDFT calculations support that the fluorescence ‘turn-on’ of IC originates from blocking the electron transfer of the nitrogen lone pair upon complexation with Cu²⁺. IC was successfully applied to microscopic imaging for detection of Cu²⁺ in LLC-MK2 cells (in vitro) and several living organs (in vivo).

Original language	English
Pages (from-to)	3165-3167
Number of pages	3
Journal	Chemical Communications
Volume	47
Issue number	11
DOIs	https://doi.org/10.1039/c0cc05421f
Publication status	Published - 2011 Mar 1

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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title = "Rationally designed fluorescence {\textquoteleft}turn-on{\textquoteright} sensor for Cu2+",

abstract = "A rationally designed, coumarin-based fluorescent sensor imino-coumarin (IC) displays high selectivity for Cu2+ over a variety of competing metal ions in aqueous solution with a significant fluorescence increase. DFT/TDDFT calculations support that the fluorescence {\textquoteleft}turn-on{\textquoteright} of IC originates from blocking the electron transfer of the nitrogen lone pair upon complexation with Cu2+. IC was successfully applied to microscopic imaging for detection of Cu2+ in LLC-MK2 cells (in vitro) and several living organs (in vivo).",

author = "Ko, {Kyoung Chul} and Wu, {Jia Sheng} and Kim, {Hyun Jung} and Kwon, {Pil Seung} and Kim, {Jong Wan} and Bartsch, {Richard A.} and Lee, {Jin Yong} and Kim, {Jong Seung}",

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AU - Ko, Kyoung Chul

AU - Wu, Jia Sheng

AU - Kim, Hyun Jung

AU - Kwon, Pil Seung

AU - Kim, Jong Wan

AU - Bartsch, Richard A.

AU - Lee, Jin Yong

AU - Kim, Jong Seung

PY - 2011/3/1

Y1 - 2011/3/1

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AB - A rationally designed, coumarin-based fluorescent sensor imino-coumarin (IC) displays high selectivity for Cu2+ over a variety of competing metal ions in aqueous solution with a significant fluorescence increase. DFT/TDDFT calculations support that the fluorescence ‘turn-on’ of IC originates from blocking the electron transfer of the nitrogen lone pair upon complexation with Cu2+. IC was successfully applied to microscopic imaging for detection of Cu2+ in LLC-MK2 cells (in vitro) and several living organs (in vivo).

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SP - 3165

EP - 3167

JO - Chemical Communications

JF - Chemical Communications

IS - 11

ER -

Rationally designed fluorescence ‘turn-on’ sensor for Cu²⁺

Abstract

ASJC Scopus subject areas

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