Rationally designed fluorescence 'turn-on' sensor for Cu2+

Kyoung Chul Ko, Jia Sheng Wu, Hyun Jung Kim, Pil Seung Kwon, Jong Wan Kim, Richard A. Bartsch, Jin Yong Lee, Jong Seung Kim

Research output: Contribution to journalArticle

143 Citations (Scopus)


A rationally designed, coumarin-based fluorescent sensor imino-coumarin (IC) displays high selectivity for Cu2+ over a variety of competing metal ions in aqueous solution with a significant fluorescence increase. DFT/TDDFT calculations support that the fluorescence 'turn-on' of IC originates from blocking the electron transfer of the nitrogen lone pair upon complexation with Cu2+. IC was successfully applied to microscopic imaging for detection of Cu2+ in LLC-MK2 cells (in vitro) and several living organs (in vivo).

Original languageEnglish
Pages (from-to)3165-3167
Number of pages3
JournalChemical Communications
Issue number11
Publication statusPublished - 2011 Mar 21

ASJC Scopus subject areas

  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Catalysis
  • Chemistry(all)

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  • Cite this

    Ko, K. C., Wu, J. S., Kim, H. J., Kwon, P. S., Kim, J. W., Bartsch, R. A., Lee, J. Y., & Kim, J. S. (2011). Rationally designed fluorescence 'turn-on' sensor for Cu2+ Chemical Communications, 47(11), 3165-3167. https://doi.org/10.1039/c0cc05421f