Rationally designed non-enzymatic fluorogenic 'turn-on' probe for uric acid

Tuhin Pradhan; Sukhendu Maiti; Rajesh Kumar; Yun Hak Lee; Jong Wan Kim; Joung Hae Lee; Jong Seung Kim

doi:10.1016/j.dyepig.2015.05.001

Rationally designed non-enzymatic fluorogenic 'turn-on' probe for uric acid

Tuhin Pradhan, Sukhendu Maiti, Rajesh Kumar, Yun Hak Lee, Jong Wan Kim, Joung Hae Lee, Jong Seung Kim

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Abstract The simple and cost-effective detection of uric acid in serum or urine is highly desirable as uric acid acts as a biomarker for various diseases. Herein, we report a rationally designed, non-enzymatic probe for the detection of uric acid in serum samples over a wide range of concentrations (lower: ∼60 μM, higher: ∼700 μM and normal: ∼120-380 μM) with 'turn-on' fluorogenic behaviour.

Original language	English
Article number	4764
Pages (from-to)	1-6
Number of pages	6
Journal	Dyes and Pigments
Volume	121
DOIs	https://doi.org/10.1016/j.dyepig.2015.05.001
Publication status	Published - 2015 May 26

Keywords

BODIPY
Fluorescence
Hydrogen bonding
Non-enzymatic
PET
Uric acid

ASJC Scopus subject areas

Chemical Engineering(all)
Process Chemistry and Technology

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title = "Rationally designed non-enzymatic fluorogenic 'turn-on' probe for uric acid",

abstract = "Abstract The simple and cost-effective detection of uric acid in serum or urine is highly desirable as uric acid acts as a biomarker for various diseases. Herein, we report a rationally designed, non-enzymatic probe for the detection of uric acid in serum samples over a wide range of concentrations (lower: ∼60 μM, higher: ∼700 μM and normal: ∼120-380 μM) with 'turn-on' fluorogenic behaviour.",

keywords = "BODIPY, Fluorescence, Hydrogen bonding, Non-enzymatic, PET, Uric acid",

author = "Tuhin Pradhan and Sukhendu Maiti and Rajesh Kumar and Lee, {Yun Hak} and Kim, {Jong Wan} and Lee, {Joung Hae} and Kim, {Jong Seung}",

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T1 - Rationally designed non-enzymatic fluorogenic 'turn-on' probe for uric acid

AU - Pradhan, Tuhin

AU - Maiti, Sukhendu

AU - Kumar, Rajesh

AU - Lee, Yun Hak

AU - Kim, Jong Wan

AU - Lee, Joung Hae

AU - Kim, Jong Seung

PY - 2015/5/26

Y1 - 2015/5/26

N2 - Abstract The simple and cost-effective detection of uric acid in serum or urine is highly desirable as uric acid acts as a biomarker for various diseases. Herein, we report a rationally designed, non-enzymatic probe for the detection of uric acid in serum samples over a wide range of concentrations (lower: ∼60 μM, higher: ∼700 μM and normal: ∼120-380 μM) with 'turn-on' fluorogenic behaviour.

AB - Abstract The simple and cost-effective detection of uric acid in serum or urine is highly desirable as uric acid acts as a biomarker for various diseases. Herein, we report a rationally designed, non-enzymatic probe for the detection of uric acid in serum samples over a wide range of concentrations (lower: ∼60 μM, higher: ∼700 μM and normal: ∼120-380 μM) with 'turn-on' fluorogenic behaviour.

KW - BODIPY

KW - Fluorescence

KW - Hydrogen bonding

KW - Non-enzymatic

KW - PET

KW - Uric acid

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DO - 10.1016/j.dyepig.2015.05.001

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JO - Dyes and Pigments

JF - Dyes and Pigments

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