Rationally designed non-enzymatic fluorogenic 'turn-on' probe for uric acid

Tuhin Pradhan; Sukhendu Maiti; Rajesh Kumar; Yun Hak Lee; Jong Wan Kim; Joung Hae Lee; Jong Seung Kim

doi:10.1016/j.dyepig.2015.05.001

Rationally designed non-enzymatic fluorogenic 'turn-on' probe for uric acid

Tuhin Pradhan, Sukhendu Maiti, Rajesh Kumar, Yun Hak Lee, Jong Wan Kim, Joung Hae Lee, Jong Seung Kim

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Abstract The simple and cost-effective detection of uric acid in serum or urine is highly desirable as uric acid acts as a biomarker for various diseases. Herein, we report a rationally designed, non-enzymatic probe for the detection of uric acid in serum samples over a wide range of concentrations (lower: ∼60 μM, higher: ∼700 μM and normal: ∼120-380 μM) with 'turn-on' fluorogenic behaviour.

Original language	English
Article number	4764
Pages (from-to)	1-6
Number of pages	6
Journal	Dyes and Pigments
Volume	121
DOIs	https://doi.org/10.1016/j.dyepig.2015.05.001
Publication status	Published - 2015 May 26

Keywords

BODIPY
Fluorescence
Hydrogen bonding
Non-enzymatic
PET
Uric acid

ASJC Scopus subject areas

Chemical Engineering(all)
Process Chemistry and Technology

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10.1016/j.dyepig.2015.05.001

Cite this

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title = "Rationally designed non-enzymatic fluorogenic 'turn-on' probe for uric acid",

abstract = "Abstract The simple and cost-effective detection of uric acid in serum or urine is highly desirable as uric acid acts as a biomarker for various diseases. Herein, we report a rationally designed, non-enzymatic probe for the detection of uric acid in serum samples over a wide range of concentrations (lower: ∼60 μM, higher: ∼700 μM and normal: ∼120-380 μM) with 'turn-on' fluorogenic behaviour.",

keywords = "BODIPY, Fluorescence, Hydrogen bonding, Non-enzymatic, PET, Uric acid",

author = "Tuhin Pradhan and Sukhendu Maiti and Rajesh Kumar and Lee, {Yun Hak} and Kim, {Jong Wan} and Lee, {Joung Hae} and Kim, {Jong Seung}",

note = "Funding Information: The authors are grateful for supports from the National Natural Science Foundation of China (Nos.21266002 and 21566004), the Guangxi Natural Science Foundation (2015GXNSFAA139036) and the Scientific Research Foundation of Guangxi University (Nos. XGZ120081 and XTZ140787). Publisher Copyright: {\textcopyright} 2015 Published by Elsevier Ltd.",

year = "2015",

month = may,

day = "26",

doi = "10.1016/j.dyepig.2015.05.001",

language = "English",

volume = "121",

pages = "1--6",

journal = "Dyes and Pigments",

issn = "0143-7208",

publisher = "Elsevier BV",

}

TY - JOUR

T1 - Rationally designed non-enzymatic fluorogenic 'turn-on' probe for uric acid

AU - Pradhan, Tuhin

AU - Maiti, Sukhendu

AU - Kumar, Rajesh

AU - Lee, Yun Hak

AU - Kim, Jong Wan

AU - Lee, Joung Hae

AU - Kim, Jong Seung

N1 - Funding Information: The authors are grateful for supports from the National Natural Science Foundation of China (Nos.21266002 and 21566004), the Guangxi Natural Science Foundation (2015GXNSFAA139036) and the Scientific Research Foundation of Guangxi University (Nos. XGZ120081 and XTZ140787). Publisher Copyright: © 2015 Published by Elsevier Ltd.

PY - 2015/5/26

Y1 - 2015/5/26

N2 - Abstract The simple and cost-effective detection of uric acid in serum or urine is highly desirable as uric acid acts as a biomarker for various diseases. Herein, we report a rationally designed, non-enzymatic probe for the detection of uric acid in serum samples over a wide range of concentrations (lower: ∼60 μM, higher: ∼700 μM and normal: ∼120-380 μM) with 'turn-on' fluorogenic behaviour.

AB - Abstract The simple and cost-effective detection of uric acid in serum or urine is highly desirable as uric acid acts as a biomarker for various diseases. Herein, we report a rationally designed, non-enzymatic probe for the detection of uric acid in serum samples over a wide range of concentrations (lower: ∼60 μM, higher: ∼700 μM and normal: ∼120-380 μM) with 'turn-on' fluorogenic behaviour.

KW - BODIPY

KW - Fluorescence

KW - Hydrogen bonding

KW - Non-enzymatic

KW - PET

KW - Uric acid

UR - http://www.scopus.com/inward/record.url?scp=84929991029&partnerID=8YFLogxK

U2 - 10.1016/j.dyepig.2015.05.001

DO - 10.1016/j.dyepig.2015.05.001

M3 - Article

AN - SCOPUS:84929991029

VL - 121

SP - 1

EP - 6

JO - Dyes and Pigments

JF - Dyes and Pigments

SN - 0143-7208

M1 - 4764

ER -

Rationally designed non-enzymatic fluorogenic 'turn-on' probe for uric acid

Abstract

Keywords

ASJC Scopus subject areas

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