Re-endothelization and inflammatory reaction at site of overlapping drug-eluting stents in a porcine coronary in-stent restenosis model

Sang Yeob Lim, Ho Jeong Myung, Ha Kim Jeong, Rok Lee Sang, Youn Moon Jae, Joon Hong Young, Han Kim Ju, Youngkeun Ahn, Gwan Cho Jeong, Chun Park Jong, Ki Seok Kim, Seung Jae Joo, Chaee Kang Jung

Research output: Contribution to journalArticle

Abstract

Background and Objectives : This study was conducted to evaluate the inflammatory reaction at sites of overlapping stents in a porcine in-stent restenosis (ISR) model. Materials and Methods : Twenty bare metal stents (BMS, Group I; n=10), 20 sirolimus-eluting stents (SES, Group II; n=10), 20 paclitaxel-eluting stents (PES, Group III; n=10), 10 PESs and 10 SESs (Group IV; n=10) were deployed and overlapped in the left anterior descending coronary arteries of 40 pigs. Follow-up coronary angiograms and histopathologic analysis were performed at 4 weeks after stenting. Results : The minimal luminal diameter of the overlapped segment at 4 weeks was smaller in group I than that in the other groups (1.78±0.13 mm vs. 2.79±0.09 mm vs. 2.90±0.04 mm vs. 2.80±0.07 mm, respectively, p<0.001). The neointimal area (5.51±0.58 mm2 vs. 2.38±0.53 mm2 vs. 2.07± 0.37 mm2 vs. 2.39 ±0.58 mm2, respectively, p<0.001) and the area stenosis (68.74±4.02% vs. 27.79±4.73% vs. 23.66±3.24% vs. 27.63±4.07%, respectively, p<0.001) of the overlapped segment were significantly higher in Group I than that in the other groups. The inflammatory score of the overlapped segment was significantly higher in Group III than that in the other groups (1.80±0.42 vs. 2.10±0.32 vs. 2.90±0.31 vs. 2.50±0.52, respectively, p<0.001). The endothelization score of the overlapped segment was significantly lower in Group III than that in the other groups (2.80±0.42 vs. 2.30±0.67 vs. 1.30±0.48 vs. 2.10±0.74, respectively, p<0.001). Conclusion : Compared with the BMS, the DES inhibits neointimal hyperplasia, but inflammation and poor endothelization are observed at the sites of overlapped stents.

Original languageEnglish
Pages (from-to)33-38
Number of pages6
JournalKorean Circulation Journal
Volume37
Issue number1
Publication statusPublished - 2007 Jan 1
Externally publishedYes

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Drug-Eluting Stents
Stents
Swine
Sirolimus
Paclitaxel
Hyperplasia
Coronary Vessels
Angiography
Pathologic Constriction
Metals
Inflammation

Keywords

  • Coronary disease
  • Restenosis
  • Stents

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Re-endothelization and inflammatory reaction at site of overlapping drug-eluting stents in a porcine coronary in-stent restenosis model. / Lim, Sang Yeob; Myung, Ho Jeong; Jeong, Ha Kim; Sang, Rok Lee; Jae, Youn Moon; Young, Joon Hong; Ju, Han Kim; Ahn, Youngkeun; Jeong, Gwan Cho; Jong, Chun Park; Kim, Ki Seok; Joo, Seung Jae; Jung, Chaee Kang.

In: Korean Circulation Journal, Vol. 37, No. 1, 01.01.2007, p. 33-38.

Research output: Contribution to journalArticle

Lim, SY, Myung, HJ, Jeong, HK, Sang, RL, Jae, YM, Young, JH, Ju, HK, Ahn, Y, Jeong, GC, Jong, CP, Kim, KS, Joo, SJ & Jung, CK 2007, 'Re-endothelization and inflammatory reaction at site of overlapping drug-eluting stents in a porcine coronary in-stent restenosis model', Korean Circulation Journal, vol. 37, no. 1, pp. 33-38.
Lim, Sang Yeob ; Myung, Ho Jeong ; Jeong, Ha Kim ; Sang, Rok Lee ; Jae, Youn Moon ; Young, Joon Hong ; Ju, Han Kim ; Ahn, Youngkeun ; Jeong, Gwan Cho ; Jong, Chun Park ; Kim, Ki Seok ; Joo, Seung Jae ; Jung, Chaee Kang. / Re-endothelization and inflammatory reaction at site of overlapping drug-eluting stents in a porcine coronary in-stent restenosis model. In: Korean Circulation Journal. 2007 ; Vol. 37, No. 1. pp. 33-38.
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abstract = "Background and Objectives : This study was conducted to evaluate the inflammatory reaction at sites of overlapping stents in a porcine in-stent restenosis (ISR) model. Materials and Methods : Twenty bare metal stents (BMS, Group I; n=10), 20 sirolimus-eluting stents (SES, Group II; n=10), 20 paclitaxel-eluting stents (PES, Group III; n=10), 10 PESs and 10 SESs (Group IV; n=10) were deployed and overlapped in the left anterior descending coronary arteries of 40 pigs. Follow-up coronary angiograms and histopathologic analysis were performed at 4 weeks after stenting. Results : The minimal luminal diameter of the overlapped segment at 4 weeks was smaller in group I than that in the other groups (1.78±0.13 mm vs. 2.79±0.09 mm vs. 2.90±0.04 mm vs. 2.80±0.07 mm, respectively, p<0.001). The neointimal area (5.51±0.58 mm2 vs. 2.38±0.53 mm2 vs. 2.07± 0.37 mm2 vs. 2.39 ±0.58 mm2, respectively, p<0.001) and the area stenosis (68.74±4.02{\%} vs. 27.79±4.73{\%} vs. 23.66±3.24{\%} vs. 27.63±4.07{\%}, respectively, p<0.001) of the overlapped segment were significantly higher in Group I than that in the other groups. The inflammatory score of the overlapped segment was significantly higher in Group III than that in the other groups (1.80±0.42 vs. 2.10±0.32 vs. 2.90±0.31 vs. 2.50±0.52, respectively, p<0.001). The endothelization score of the overlapped segment was significantly lower in Group III than that in the other groups (2.80±0.42 vs. 2.30±0.67 vs. 1.30±0.48 vs. 2.10±0.74, respectively, p<0.001). Conclusion : Compared with the BMS, the DES inhibits neointimal hyperplasia, but inflammation and poor endothelization are observed at the sites of overlapped stents.",
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T1 - Re-endothelization and inflammatory reaction at site of overlapping drug-eluting stents in a porcine coronary in-stent restenosis model

AU - Lim, Sang Yeob

AU - Myung, Ho Jeong

AU - Jeong, Ha Kim

AU - Sang, Rok Lee

AU - Jae, Youn Moon

AU - Young, Joon Hong

AU - Ju, Han Kim

AU - Ahn, Youngkeun

AU - Jeong, Gwan Cho

AU - Jong, Chun Park

AU - Kim, Ki Seok

AU - Joo, Seung Jae

AU - Jung, Chaee Kang

PY - 2007/1/1

Y1 - 2007/1/1

N2 - Background and Objectives : This study was conducted to evaluate the inflammatory reaction at sites of overlapping stents in a porcine in-stent restenosis (ISR) model. Materials and Methods : Twenty bare metal stents (BMS, Group I; n=10), 20 sirolimus-eluting stents (SES, Group II; n=10), 20 paclitaxel-eluting stents (PES, Group III; n=10), 10 PESs and 10 SESs (Group IV; n=10) were deployed and overlapped in the left anterior descending coronary arteries of 40 pigs. Follow-up coronary angiograms and histopathologic analysis were performed at 4 weeks after stenting. Results : The minimal luminal diameter of the overlapped segment at 4 weeks was smaller in group I than that in the other groups (1.78±0.13 mm vs. 2.79±0.09 mm vs. 2.90±0.04 mm vs. 2.80±0.07 mm, respectively, p<0.001). The neointimal area (5.51±0.58 mm2 vs. 2.38±0.53 mm2 vs. 2.07± 0.37 mm2 vs. 2.39 ±0.58 mm2, respectively, p<0.001) and the area stenosis (68.74±4.02% vs. 27.79±4.73% vs. 23.66±3.24% vs. 27.63±4.07%, respectively, p<0.001) of the overlapped segment were significantly higher in Group I than that in the other groups. The inflammatory score of the overlapped segment was significantly higher in Group III than that in the other groups (1.80±0.42 vs. 2.10±0.32 vs. 2.90±0.31 vs. 2.50±0.52, respectively, p<0.001). The endothelization score of the overlapped segment was significantly lower in Group III than that in the other groups (2.80±0.42 vs. 2.30±0.67 vs. 1.30±0.48 vs. 2.10±0.74, respectively, p<0.001). Conclusion : Compared with the BMS, the DES inhibits neointimal hyperplasia, but inflammation and poor endothelization are observed at the sites of overlapped stents.

AB - Background and Objectives : This study was conducted to evaluate the inflammatory reaction at sites of overlapping stents in a porcine in-stent restenosis (ISR) model. Materials and Methods : Twenty bare metal stents (BMS, Group I; n=10), 20 sirolimus-eluting stents (SES, Group II; n=10), 20 paclitaxel-eluting stents (PES, Group III; n=10), 10 PESs and 10 SESs (Group IV; n=10) were deployed and overlapped in the left anterior descending coronary arteries of 40 pigs. Follow-up coronary angiograms and histopathologic analysis were performed at 4 weeks after stenting. Results : The minimal luminal diameter of the overlapped segment at 4 weeks was smaller in group I than that in the other groups (1.78±0.13 mm vs. 2.79±0.09 mm vs. 2.90±0.04 mm vs. 2.80±0.07 mm, respectively, p<0.001). The neointimal area (5.51±0.58 mm2 vs. 2.38±0.53 mm2 vs. 2.07± 0.37 mm2 vs. 2.39 ±0.58 mm2, respectively, p<0.001) and the area stenosis (68.74±4.02% vs. 27.79±4.73% vs. 23.66±3.24% vs. 27.63±4.07%, respectively, p<0.001) of the overlapped segment were significantly higher in Group I than that in the other groups. The inflammatory score of the overlapped segment was significantly higher in Group III than that in the other groups (1.80±0.42 vs. 2.10±0.32 vs. 2.90±0.31 vs. 2.50±0.52, respectively, p<0.001). The endothelization score of the overlapped segment was significantly lower in Group III than that in the other groups (2.80±0.42 vs. 2.30±0.67 vs. 1.30±0.48 vs. 2.10±0.74, respectively, p<0.001). Conclusion : Compared with the BMS, the DES inhibits neointimal hyperplasia, but inflammation and poor endothelization are observed at the sites of overlapped stents.

KW - Coronary disease

KW - Restenosis

KW - Stents

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