TY - JOUR
T1 -
Reaction-based fluorescent probes for SO
2
derivatives and their biological applications
AU - Li, Kun
AU - Li, Ling Ling
AU - Zhou, Qian
AU - Yu, Kang Kang
AU - Kim, Jong Seung
AU - Yu, Xiao Qi
PY - 2019/6/1
Y1 - 2019/6/1
N2 -
As a well-known toxic air pollutant, SO
2
and its derivatives can cause great harm to the human body, including respiratory responses, allergic reactions, cancer, neurological disorders and cardiovascular diseases. On the other hand, SO
2
can be endogenously generated in mammals and serves as a gaseous signaling molecule. Evidences show that SO
2
and its derivatives play crucial roles in modulating a wide range of physiological processes, including vasodilatation, antihypertension, regulation of cardiovascular function and intracellular redox status. The molecular mechanisms dictating the biological formation of SO
2
and its role in many biological processes remain largely unclear. Reaction-based fluorescent probes offer powerful means to monitor the physiological actions of SO
2
derivatives in their native environments with minimal perturbation to the living systems. This review shows up-to-date research trends on reaction-based fluorescent probes for SO
2
derivatives. The design principles and chemical structures of the probes and their biological applications are highlighted.
AB -
As a well-known toxic air pollutant, SO
2
and its derivatives can cause great harm to the human body, including respiratory responses, allergic reactions, cancer, neurological disorders and cardiovascular diseases. On the other hand, SO
2
can be endogenously generated in mammals and serves as a gaseous signaling molecule. Evidences show that SO
2
and its derivatives play crucial roles in modulating a wide range of physiological processes, including vasodilatation, antihypertension, regulation of cardiovascular function and intracellular redox status. The molecular mechanisms dictating the biological formation of SO
2
and its role in many biological processes remain largely unclear. Reaction-based fluorescent probes offer powerful means to monitor the physiological actions of SO
2
derivatives in their native environments with minimal perturbation to the living systems. This review shows up-to-date research trends on reaction-based fluorescent probes for SO
2
derivatives. The design principles and chemical structures of the probes and their biological applications are highlighted.
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U2 - 10.1016/j.ccr.2019.03.001
DO - 10.1016/j.ccr.2019.03.001
M3 - Review article
AN - SCOPUS:85062879530
VL - 388
SP - 310
EP - 333
JO - Coordination Chemistry Reviews
JF - Coordination Chemistry Reviews
SN - 0010-8545
ER -