Reactive oxygen species and p38 MAPK regulate Bax translocation and calcium redistribution in salubrinal-induced apoptosis of EBV-transformed B cells

Ga Bin Park, Yeong Seok Kim, Hyun Kyung Lee, Hyunkeun Song, Seonghan Kim, Dae Ho Cho, Dae Young Hur

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Salubrinal is a specific eIF2α phosphatase inhibitor that inhibits ER stress-mediated apoptosis. However, maintaining hyper-phosphorylated eIF2α state with high doses of salubrinal treatment promotes apoptosis in some cancer cells. In this report, we found that salubrinal induced apoptosis of EBV-transformed B cells. Notably, salubrinal induced ROS generation and p38 MPAK activation, which then induced expression of FasL. Moreover, salubrinal subsequently led to activation of caspases, calcium redistribution, Bax translocation, cytochrome c release, and apoptosis. These findings suggest that salubrinal may be a novel therapeutic approach for EBV-associated malignant diseases.

Original languageEnglish
Pages (from-to)235-248
Number of pages14
JournalCancer letters
Volume313
Issue number2
DOIs
Publication statusPublished - 2011 Dec 27
Externally publishedYes

Fingerprint

p38 Mitogen-Activated Protein Kinases
Human Herpesvirus 4
Reactive Oxygen Species
B-Lymphocytes
Apoptosis
Calcium
Caspases
Cytochromes c
Phosphoric Monoester Hydrolases
salubrinal
Neoplasms

Keywords

  • Apoptosis
  • B cell
  • Bax
  • Calcium
  • EBV
  • P38 MAPK
  • ROS
  • Salubrinal

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Reactive oxygen species and p38 MAPK regulate Bax translocation and calcium redistribution in salubrinal-induced apoptosis of EBV-transformed B cells. / Park, Ga Bin; Kim, Yeong Seok; Lee, Hyun Kyung; Song, Hyunkeun; Kim, Seonghan; Cho, Dae Ho; Hur, Dae Young.

In: Cancer letters, Vol. 313, No. 2, 27.12.2011, p. 235-248.

Research output: Contribution to journalArticle

Park, Ga Bin ; Kim, Yeong Seok ; Lee, Hyun Kyung ; Song, Hyunkeun ; Kim, Seonghan ; Cho, Dae Ho ; Hur, Dae Young. / Reactive oxygen species and p38 MAPK regulate Bax translocation and calcium redistribution in salubrinal-induced apoptosis of EBV-transformed B cells. In: Cancer letters. 2011 ; Vol. 313, No. 2. pp. 235-248.
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