Reactive oxygen species and p38 MAPK regulate Bax translocation and calcium redistribution in salubrinal-induced apoptosis of EBV-transformed B cells

Ga Bin Park, Yeong Seok Kim, Hyun Kyung Lee, Hyunkeun Song, Seonghan Kim, Dae Ho Cho, Dae Young Hur

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24 Citations (Scopus)

Abstract

Salubrinal is a specific eIF2α phosphatase inhibitor that inhibits ER stress-mediated apoptosis. However, maintaining hyper-phosphorylated eIF2α state with high doses of salubrinal treatment promotes apoptosis in some cancer cells. In this report, we found that salubrinal induced apoptosis of EBV-transformed B cells. Notably, salubrinal induced ROS generation and p38 MPAK activation, which then induced expression of FasL. Moreover, salubrinal subsequently led to activation of caspases, calcium redistribution, Bax translocation, cytochrome c release, and apoptosis. These findings suggest that salubrinal may be a novel therapeutic approach for EBV-associated malignant diseases.

Original languageEnglish
Pages (from-to)235-248
Number of pages14
JournalCancer letters
Volume313
Issue number2
DOIs
Publication statusPublished - 2011 Dec 27
Externally publishedYes

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Keywords

  • Apoptosis
  • B cell
  • Bax
  • Calcium
  • EBV
  • P38 MAPK
  • ROS
  • Salubrinal

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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